Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 57399-11-8, is researched, SMILESS is C#CC1=CC=C(C2=CC=C(Cl)C=C2)C=C1, Molecular C14H9ClJournal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called Synthesis and Antiplasmodial Activity of New Indolone N-Oxide Derivatives, Author is Nepveu, Francoise; Kim, Sothea; Boyer, Jeremie; Chatriant, Olivier; Ibrahim, Hany; Reybier, Karine; Monje, Marie-Carmen; Chevalley, Severine; Perio, Pierre; Lajoie, Barbora H.; Bouajila, Jalloul; Deharo, Eric; Sauvain, Michel; Tahar, Rachida; Basco, Leonardo; Pantaleo, Antonella; Turini, Francesco; Arese, Paolo; Valentin, Alexis; Thompson, Eloise; Vivas, Livia; Petit, Serge; Nallet, Jean-Pierre, the main research direction is indolone oxide preparation antiplasmodial activity.Computed Properties of C14H9Cl.
A series of 66 new indolone-N-oxide derivatives, e.g. I, was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ and pyrimethamine cross-resistant (K1) strains of Plasmodium falciparum (P.f.), as well as for cytotoxic concentration (CC50) on MCF7 and KB human tumor cell lines. Compound II (5-methoxy-indolone-N-oxide analog) had the most potent antiplasmodial activity in vitro (<3 nM on FcB1 and = 1.7 nM on 3D7) with a very satisfactory selectivity index (CC50 MCF7/IC50 FcB1: 14623; CC50 KB/IC50 3D7: 198823). In in vivo experiments, compound I (dioxymethylene derivatives of the indolone-N-oxide) showed the best antiplasmodial activity against Plasmodium berghei, 62% inhibition of the parasitemia at 30 mg/kg/day. Compounds in my other articles are similar to this one(4-Chloro-4'-ethynyl-1,1'-biphenyl)Computed Properties of C14H9Cl, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem