With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42923-77-3,6-Methoxy-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.
Compound 7b (2.12 g, 13.0 mmol) was dissolved in HBr (48% in H2O). The mixture was stirred at 120 C for 3h and then concentrated in vacuo. The residue was suspended in EtOAc and the solvent was evaporated to produce 24 (2.99 g, 95%) as a red-brown solid. 1H NMR (300 MHz, D2O) : 7.10 (d, J = 8.4 Hz, 1H), 6.82 – 6.75 (m, 2H), 4.28 (s, 2H), 3.48 (t, J = 6.3 Hz, 2H), 3.05 (t, J = 6.3 Hz, 2H).
42923-77-3, As the paragraph descriping shows that 42923-77-3 is playing an increasingly important role.
Reference£º
Article; Zhao, Chao; Choi, You Hee; Khadka, Daulat Bikram; Jin, Yifeng; Lee, Kwang-Youl; Cho, Won-Jea; Bioorganic and Medicinal Chemistry; vol. 24; 4; (2016); p. 789 – 801;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem