The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Product Details of 15227-42-6.Webster, Lorraine K.; Deacon, Glen B.; Buxton, David P.; Hillcoat, Brian L.; James, Alison M.; Roos, Ian A. G.; Thomson, Robin J.; Wakelin, Laurence P. G.; Williams, Tracey L. published the article 《cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity》 about this compound( cas:15227-42-6 ) in Journal of Medicinal Chemistry. Keywords: bispyridine platinum amide antitumor. Let’s learn more about this compound (cas:15227-42-6).
The platinum(II) organoamides [Pt(NRCH2)2L2] (L = pyridine (py), R = p-HC6F4, C6F5, p-IC6F4, p-ClC6F4, p-C6F5C6F4; L = 4-methylpyridine, R = p-HC6F4) and [Pt(NRCH2CH2NR’)(py)2] (R = p-HC6F4, R’ = C6F5, p-BrC6F4, or p-MeC6F4) inhibit the growth of murine L1210 leukemia cells in culture with ID50 values for continuous exposure in the range 0.6-2.7 μM. Representative complexes are also active against L1210 cells in 2-h pulse exposures, as well as against the cisplatin-resistant variant L1210/DDP and human colonic carcinoma cell lines HT 29 and BE. Three complexes [Pt(NRCH2)2L2] (R = p-HC6F4, C6F5, or p-IC6F4) have good activity (T/C ≥ 180%) against P388 leukemia in mice, and all other compounds tested are active except when R = p-C6F5C6F4, L = py. Although the mol. basis of the biol. activity of these complexes is not known, the observation of good activity for amineplatinum(II) compounds with no hydrogen substituents on the nitrogen donor atoms introduces a new factor in the anticancer behavior of platinum(II) complexes.
The article 《cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity》 also mentions many details about this compound(15227-42-6)Product Details of 15227-42-6, you can pay attention to it, because details determine success or failure
Reference:
Tetrahydroisoquinoline – Wikipedia,
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