29726-60-1, 3-Methyl-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
186: 6-{5-chloro-2-[(oxan-4-yl)amino]pyridin-4-yl}-2-[2-(3-methyl-1 , 2,3,4- tetrahydroisoquinolin-2-yl)-2-oxoethyl]-2,3-dihydro-1 H-isoindol-1 -one (2759) (2760) A stirred solution of 2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyridin-4-yl}-1-oxo-2,3-dihydro-1 H- isoindol-2-yl)acetic acid (Preparation 136, 130 mg, 0.32 mmol) in anhydrous 1 ,4-dioxane (3.2 mL) under nitrogen was treated with DIPEA (1 13 muIota_, 0.65 mmol), HBTU (250 mg, 0.65 mmol) and then 3-methyl-1 ,2,3,4-tetrahydro-isoquinoline (71 mg, 0.49 mmol). After 16 hours the mixture was diluted with water and extracted with EtOAc (x3). The combined organic layers were washed with brine, dried over MgS04, filtered and concentrated under vacuum. The residue was purified by preparative HPLC to give the title compound (57 mg, 34 %) as a colourless solid. NMR (400 MHz, Me-d3-OD): 8.05 (1 H, s), 7.87 (1 H, s), 7.74-7.67 (2H, m), 7.23 (4H, d), 6.57 (1 H, s), 5.04 (1 H, d), 4.73-4.64 (5H, m), 4.64-4.60 (1 H, m), 4.38-4.31 (1 H, m), 3.99 (3H, d), 3.60-3.54 (4H, m), 3.17-3.08 (1 H, m), 2.82-2.69 (1 H, m), 2.01 (2H, d), 1.62-1.50 (2H, m), 1.27 (2H, d), 1.12 (2H, d). MS: [M+H]+ = 531.
29726-60-1, The synthetic route of 29726-60-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; BERDINI, Valerio; BUCK, Ildiko Maria; DAY, James Edward Harvey; GRIFFITHS-JONES, Charlotte Mary; HEIGHTMAN, Thomas Daniel; HOWARD, Steven; MURRAY, Christopher William; NORTON, David; O’REILLY, Marc; WOOLFORD, Alison Jo-Anne; COOKE, Michael Liam; COUSIN, David; ONIONS, Stuart Thomas; SHANNON, Jonathan Martin; WATTS, John Paul; (867 pag.)WO2017/68412; (2017); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem