Product Details of 15227-42-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity. Author is Webster, Lorraine K.; Deacon, Glen B.; Buxton, David P.; Hillcoat, Brian L.; James, Alison M.; Roos, Ian A. G.; Thomson, Robin J.; Wakelin, Laurence P. G.; Williams, Tracey L..
The platinum(II) organoamides [Pt(NRCH2)2L2] (L = pyridine (py), R = p-HC6F4, C6F5, p-IC6F4, p-ClC6F4, p-C6F5C6F4; L = 4-methylpyridine, R = p-HC6F4) and [Pt(NRCH2CH2NR’)(py)2] (R = p-HC6F4, R’ = C6F5, p-BrC6F4, or p-MeC6F4) inhibit the growth of murine L1210 leukemia cells in culture with ID50 values for continuous exposure in the range 0.6-2.7 μM. Representative complexes are also active against L1210 cells in 2-h pulse exposures, as well as against the cisplatin-resistant variant L1210/DDP and human colonic carcinoma cell lines HT 29 and BE. Three complexes [Pt(NRCH2)2L2] (R = p-HC6F4, C6F5, or p-IC6F4) have good activity (T/C ≥ 180%) against P388 leukemia in mice, and all other compounds tested are active except when R = p-C6F5C6F4, L = py. Although the mol. basis of the biol. activity of these complexes is not known, the observation of good activity for amineplatinum(II) compounds with no hydrogen substituents on the nitrogen donor atoms introduces a new factor in the anticancer behavior of platinum(II) complexes.
Different reactions of this compound(cis-Dichlorobis(pyridine)platinum(II))Product Details of 15227-42-6 require different conditions, so the reaction conditions are very important.
Reference:
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