Category: tetrahydroisoquinolineOn October 10, 2014 ,《Direct high-performance liquid chromatographic enantioseparation of secondary amino acids on Cinchona alkaloid-based chiral zwitterionic stationary phases. Unusual temperature behavior》 was published in Journal of Chromatography A. The article was written by Ilisz, Istvan; Gecse, Zsanett; Pataj, Zoltan; Fulop, Ferenc; Toth, Geza; Lindner, Wolfgang; Peter, Antal. The article contains the following contents:
Two chiral stationary phases containing a quinine- or a quinidine-based zwitterionic ion-exchanger as chiral selector were applied for the enantioseparation of 27 unusual cyclic secondary α-amino acids. The effects of the nature and concentration of the bulk solvent, the acid and base additives, the structures of the analytes and temperature on the enantioresoln. were studied. To study the effects of temperature and to obtain thermodn. parameters, experiments were carried out at constant mobile phase compositions in the temperature range -5 to 55°. The thermodn. parameters indicated that in most cases the separations were enthalpy-driven, but some entropy-driven separations were also observed The sequence of elution of the enantiomers was determined in most cases. In the experiment, the researchers used (R)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(cas: 152286-30-1Category: tetrahydroisoquinoline)
(R)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(cas: 152286-30-1) belongs to tetrahydroisoquinoline. Tetrahydroisoquinoline Reactions: As a secondary amine, tetrahydroisoquinoline has weakly basic properties and forms salts with strong acids.Category: tetrahydroisoquinoline It can be dehydrogenated to give isoquinoline and hydrogenated to decahydroisoquinoline. Like other secondary amines, tetrahydroisoquinoline can be oxidized to the corresponding nitrone using hydrogen peroxide, catalyzed by selenium dioxide.
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem