Peter, Antal; Toth, Geza; Olajos, Edit; Fueloep, Ferenc; Tourwe, Dirk published an article in Journal of Chromatography A. The title of the article was 《Monitoring of optical isomers of some conformationally constrained amino acids with tetrahydroisoquinoline or tetraline ring structures. Part II》.Formula: C10H11NO3 The author mentioned the following in the article:
Conformationally constrained amino acids were synthesized in chiral or racemic forms: D- and L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic), the erythro-D,L-4-Me analog, D- and L-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, D- and L-7-hydroxy-6,8-diiodo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, D,L-2-aminotetraline-2-carboxylic acid, D,L-6-hydroxy-2-aminotetraline-2-carboxylic acid and D,L-6-methoxy-2-aminotetraline-2-carboxylic acid. The optical isomers were characterized and identified by applying precolumn derivatization with chiral reagents (1-fluoro-2,4-dinitrophenyl-5-L-alanine amide and 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate) and enzymic digestion with L-amino acid oxidase, carboxypeptidase A and α-chymotrypsin. The HPLC conditions (pH, eluent composition and different buffers) were varied to obtain optimum separations In the part of experimental materials, we found many familiar compounds, such as (R)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(cas: 152286-30-1Formula: C10H11NO3)
(R)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(cas: 152286-30-1) belongs to tetrahydroisoquinoline. Tetrahydroisoquinoline Reactions: As a secondary amine, tetrahydroisoquinoline has weakly basic properties and forms salts with strong acids.Formula: C10H11NO3 It can be dehydrogenated to give isoquinoline and hydrogenated to decahydroisoquinoline. Like other secondary amines, tetrahydroisoquinoline can be oxidized to the corresponding nitrone using hydrogen peroxide, catalyzed by selenium dioxide.
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem