Application In Synthesis of (R)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acidOn May 13, 1994 ,《Monitoring of optical isomers of some conformationally constrained amino acids with tetrahydroisoquinoline or tetraline ring structures》 appeared in Journal of Chromatography A. The author of the article were Peter, Antal; Toth, Geza; Tourwe, Dirk. The article conveys some information:
Conformationally constrained amino acids were synthesized in optically pure or racemic forms: D- and L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, its erythro-D,L-4-Me analog, D- and L-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid, D- and L-1,2,3,4-tetrahydro-7-hydroxy-6,8-dibromo- and -6,8-diiodoisoquinoline-3-carboxylic acid and D,L-6-hydroxy-2-aminotetraline-2-carboxylic acid. A method was developed for the separation and identification of optical isomers using precolumn derivatization with chiral derivatization reagents: 1-fluoro-2,4-dinitrophenyl-4-L-alaninamide and 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate. The effects of pH, eluent composition and different buffers on the separation were also investigated. In the experiment, the researchers used (R)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(cas: 152286-30-1Application In Synthesis of (R)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid)
(R)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(cas: 152286-30-1) belongs to tetrahydroisoquinoline. Tetrahydroisoquinoline Reactions: As a secondary amine, tetrahydroisoquinoline has weakly basic properties and forms salts with strong acids.Application In Synthesis of (R)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid It can be dehydrogenated to give isoquinoline and hydrogenated to decahydroisoquinoline. Like other secondary amines, tetrahydroisoquinoline can be oxidized to the corresponding nitrone using hydrogen peroxide, catalyzed by selenium dioxide.
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem