Montgomery, Deanna; Anand, Jessica P.; Griggs, Nicholas W.; Fernandez, Thomas J.; Hartman, Joshua G.; Sanchez-Santiago, Ashley A.; Pogozheva, Irina D.; Traynor, John R.; Mosberg, Henry I. published the artcile< Novel dimethyltyrosine-tetrahydroisoquinoline peptidomimetics with aromatic tetrahydroisoquinoline substitutions show in vitro Kappa and Mu opioid receptor agonism>, HPLC of Formula: 893566-75-1, the main research area is dimethyltyrosine tetrahydroisoquinoline peptidomimetic synthesis opioid receptor agonist; peptidomimetic opioid structure activity mol docking cocain addiction; bromination quinoline substitution protection Suzuki coupling; cocaine addiction; dimethyltyrosine−tetrahydroisoquinoline; multifunctional ligands; opioids; peptidomimetics; synthesis.
The dimethyltyrosine-tetrahydroisoquinoline (Dmt-Tiq) scaffold was originally developed in the production of selective delta opioid receptor (DOR) antagonists. Installation of a 7-benzyl pendant on the tetrahydroisoquinoline core of this classic opioid scaffold introduced kappa opioid receptor (KOR) agonism. Further modification of this pendant resulted in retention of KOR agonism and the addition of mu opioid receptor (MOR) partial agonism, a bifunctional profile with potential to be used in the treatment of cocaine addiction.
ACS Chemical Neuroscience published new progress about Bromination. 893566-75-1 belongs to class tetrahydroisoquinoline, and the molecular formula is C14H18BrNO2, HPLC of Formula: 893566-75-1.
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem