Imidodisulfamides. 2. Substituted 1,2,3,4-tetrahydroisoquinolinylsulfonic imides as antagonists of slow-reacting substance of anaphylaxis was written by Ali, Fadia El-Fehail;Gleason, John G.;Hill, David T.;Krell, Robert D.;Kruse, Carolyn H.;Lavanchy, Patricia G.;Volpe, Beth W.. And the article was included in Journal of Medicinal Chemistry in 1982.HPLC of Formula: 82771-59-3 The following contents are mentioned in the article:
Substituted 1,2,3,4-tetrahydroisoquinolinylsulfonic imides, e.g., I (R = H, 5-, 6-, 7-, 8-Cl, 7-MeO, 6,7,8-Cl3) and 1,5-bis(arylcycloalkyl)imidodisulfamides, e.g. II, were prepared by condensation of the corresponding amine with ClSO2NHSO2Cl. In order to determine the influence of structural modifications of the imidodisulfamides on their ability to selectively antagonize SRS-A activity, a few conformationally constrained structures were examined Among these derivatives having a conformationally restricted alkylene side chain, substituted 1,2,3,4-tetrahydroisoquinolinylsulfonic imides produced optimum SRS-A antagonist activity and selectivity. These compounds were tested for antagonism of partially purified SRS-A induced contractions of isolated guinea pig ileum. In this series of tetrahydroisoquinolines, the effect of aromatic ring substitution, as well as substitution and variation of the size of the heterocyclic ring on SRS-A antagonist activity and selectivity, was studied. This study involved multiple reactions and reactants, such as 1-(1,2,3,4-Tetrahydroisoquinolin-7-yl)ethanone (cas: 82771-59-3HPLC of Formula: 82771-59-3).
1-(1,2,3,4-Tetrahydroisoquinolin-7-yl)ethanone (cas: 82771-59-3) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline can be dehydrogenated to give isoquinoline and hydrogenated to decahydroisoquinoline. An intramolecular Friedel-Crafts cyclization of an in situ generated tosylate intermediate enables an efficient construction of 3-substituted 1,2,3,4-tetrahydroisoquinolines from N,N-dibenzyl-α-aminols.HPLC of Formula: 82771-59-3
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem