A novel synthesis of isoquinolone derivatives was written by Xie, Yu;Hu, Jingang;Hong, Xiaowei;Wei, Ya;Jia, Jie. And the article was included in Youji Huaxue in 2010.Electric Literature of C10H13N This article mentions the following:
Tetrahydroisoquinoline derivatives [i.e., δ-lactams] were designed and the synthesis of the target compounds was achieved by a nucleophilic substitution, cyclization reaction using Et chloroformate and benzeneethanamine derivatives as starting materials. The above-mentioned isoquinolinone derivatives are precursors for 1,2,3,4-tetrahydroisoquinoline derivatives (no data). The key step in this sequence, a cyclization reaction, was accomplished by using polyphosphoric acid (PPA) as a catalyst conveniently and effectively under solvent-free reaction conditions. In the experiment, the researchers used many compounds, for example, 7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8Electric Literature of C10H13N).
7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline motif is often present in natural products with a broad range of biological and pharmacological activities. In particular, 1-benzyl1,2,3,4-tetrahydroisoquinolines are dopamine receptor antagonists. An efficient CuCl2-catalyzed coupling of nonfunctionalized tetrahydroisoquinolines with organozinc reagents under aerobic conditions proceeds in high yields under mild reaction conditions and is broadly applicable to a wide range of substrates. The reaction involves an iminium ion intermediate that is formed via a SET process.Electric Literature of C10H13N
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem