Catalyst-free cyclization of anthranils and cyclic amines: one-step synthesis of rutaecarpine was written by Li, Jian;Wang, Zheng-Bing;Xu, Yue;Lu, Xue-Chen;Zhu, Shang-Rong;Liu, Li. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Electric Literature of C10H13N This article mentions the following:
An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between com. available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without addnl. catalysts, and offers a practical way for the preparation of rutaecarpine [I + II → III (80%)] and its derivatives with structural diversity. In the experiment, the researchers used many compounds, for example, 7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8Electric Literature of C10H13N).
7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline can be dehydrogenated to give isoquinoline and hydrogenated to decahydroisoquinoline. Arene/Ru/TsDPEN complexes bearing a heterocyclic group catalyze the asymmetric transfer hydrogenation (ATH) of 1-aryl dihydroisoquinolines (DHIQs) to provide tetrahydroisoquinolines of high enantiomeric excess.Electric Literature of C10H13N
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem