Hu, Longqin et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2013 | CAS: 151004-92-1

(S)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid (cas: 151004-92-1) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline motif is often present in natural products with a broad range of biological and pharmacological activities. An efficient CuCl2-catalyzed coupling of nonfunctionalized tetrahydroisoquinolines with organozinc reagents under aerobic conditions proceeds in high yields under mild reaction conditions and is broadly applicable to a wide range of substrates. The reaction involves an iminium ion intermediate that is formed via a SET process.Electric Literature of C10H11NO2

Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction was written by Hu, Longqin;Magesh, Sadagopan;Chen, Lin;Wang, Lili;Lewis, Timothy A.;Chen, Yu;Khodier, Carol;Inoyama, Daigo;Beamer, Lesa J.;Emge, Thomas J.;Shen, Jian;Kerrigan, John E.;Kong, Ah-Ng Tony;Dandapani, Sivaraman;Palmer, Michelle;Schreiber, Stuart L.;Munoz, Benito. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Electric Literature of C10H11NO2 This article mentions the following:

A high-throughput screen (HTS) of the MLPCN library using a homogeneous fluorescence polarization assay identified a small mol. as a first-in-class direct inhibitor of Keap1-Nrf2 protein-protein interaction. The HTS hit has three chiral centers; a combination of flash and chiral chromatog. separation demonstrated that Keap1-binding activity resides predominantly in one stereoisomer ML334 (LH601A; I), which is at least 100× more potent than the other stereoisomers. The stereochem. of the four cis isomers was assigned using x-ray crystallog. and confirmed using stereospecific synthesis. I is functionally active in both an ARE gene reporter assay and an Nrf2 nuclear translocation assay. The stereospecific nature of binding between I and Keap1 as well as the preliminary but tractable structure-activity relationships support its use as a lead for our ongoing optimization. In the experiment, the researchers used many compounds, for example, (S)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid (cas: 151004-92-1Electric Literature of C10H11NO2).

(S)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid (cas: 151004-92-1) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline motif is often present in natural products with a broad range of biological and pharmacological activities. An efficient CuCl2-catalyzed coupling of nonfunctionalized tetrahydroisoquinolines with organozinc reagents under aerobic conditions proceeds in high yields under mild reaction conditions and is broadly applicable to a wide range of substrates. The reaction involves an iminium ion intermediate that is formed via a SET process.Electric Literature of C10H11NO2

Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem