Novel pyrimidines as acid pump antagonists (APAs) was written by Yoon, Young Ae;Park, Chan Sun;Cha, Myung Hun;Choi, Hyunho;Sim, Jae Young;Kim, Jae Gyu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Formula: C10H13N This article mentions the following:
A series of pyrimidine derivatives as acid pump antagonists (APAs) was synthesized and the inhibitory activities against H+/K+ ATPase isolated from hog gastric mucosa were determined After elaborating on substituents at C2 and C4 position of the pyrimidine scaffold, it was observed that I is a potent APA with H+/K+ ATPase, IC50 = 52 nM. In the experiment, the researchers used many compounds, for example, 7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8Formula: C10H13N).
7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8) belongs to tetrahydroisoquinoline derivatives. The tetrahydroisoquinoline skeleton is encountered in a number of bioactive compounds and drugs. An oxidative C1 arylation of tetrahydroisoquinolines with aryl Grignard reagents is mediated by diethyl azodicarboxylate (DEAD). This C-H activation under metal-free conditions delivers target compounds, including some naturally occurring alkaloids, in good yields.Formula: C10H13N
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem