Design and synthesis of nitrogen-containing benzoheterocyclic derivatives and their antipsychotic activities was written by Peng, Shaoping;Yu, Leiping;Li, Jianqi. And the article was included in Yaoxue Xuebao in 2009.Quality Control of 7-Methyl-1,2,3,4-tetrahydroisoquinoline This article mentions the following:
A series of nitrogen-containing benzoheterocyclic derivatives were synthesized and tested for their antipsychotic activities. Their structures were confirmed by 1H-NMR and HR-MS. Preliminary in vitro pharmacol. trials showed that most of the target compounds had high affinity with D2 and 5-HT2A receptors. Among the tested compounds, 20 compounds exhibited the highest affinity and D2 partial agonist activities. In vivo studies showed that 20 compounds had potent antipsychotic activities on apomorphine mice model, which was a chance to find a better precursor of D2 partial agonist for further optimization. In the experiment, the researchers used many compounds, for example, 7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8Quality Control of 7-Methyl-1,2,3,4-tetrahydroisoquinoline).
7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8) belongs to tetrahydroisoquinoline derivatives. The tetrahydroisoquinoline skeleton is encountered in a number of bioactive compounds and drugs. An efficient CuCl2-catalyzed coupling of nonfunctionalized tetrahydroisoquinolines with organozinc reagents under aerobic conditions proceeds in high yields under mild reaction conditions and is broadly applicable to a wide range of substrates. The reaction involves an iminium ion intermediate that is formed via a SET process.Quality Control of 7-Methyl-1,2,3,4-tetrahydroisoquinoline
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem