Copper-catalyzed diastereoselective aerobic intramolecular dehydrogenative coupling of hydrazones via sp3 C-H functionalization was written by Wu, Xuesong;Wang, Mian;Zhang, Guangwu;Zhao, Yan;Wang, Jianyi;Ge, Haibo. And the article was included in Chemical Science in 2015.SDS of cas: 207451-81-8 This article mentions the following:
The highly diastereoselective intramol. dehydrogenative cyclization of N,N-disubstituted hydrazones via copper-catalyzed sp3 C-H bond functionalization process is described. The reaction protocol utilizes O2 as the oxidant and shows great functional group compatibility. Computational studies suggest that a 5-center/6-electron disrotatory cyclization mechanism is probably involved in the process for controlling the diastereoselectivity. This work represents the first example of a copper-catalyzed, direct intramol. diastereoselective coupling reaction via an iminium ion intermediate. Addnl., it provides an environmentally friendly and atom efficient approach to access substituted pyrazolines, e.g, I, an important structural unit in many biol. active compounds In the experiment, the researchers used many compounds, for example, 7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8SDS of cas: 207451-81-8).
7-Methyl-1,2,3,4-tetrahydroisoquinoline (cas: 207451-81-8) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline can be dehydrogenated to give isoquinoline and hydrogenated to decahydroisoquinoline. Tetrahydroisoquinoline derivatives may be formed in the body as metabolites of some drugs, and this was once thought to be involved in the development of alcoholism.This is no longer generally accepted by the scientific community.SDS of cas: 207451-81-8
Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem