Some tips on 43207-78-9

As the paragraph descriping shows that 43207-78-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.43207-78-9,7-Methoxy-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.

Lithium aluminium hydride, L. OM solution in THF (Aldrich, 21,277-6) (22mL, 22MMOL) was added drop wise to 7-METHOXY-3, 4-dihydro-2H-isoquinolin-l-one (3. 0g, 17MMOL) in THF (25mL) at RT. After addition the reaction was refluxed for 3HRS. THE reaction was cooled to 0C and quenched by the careful addition of deionised H20 (1ML), 10% OH solution (LML) and deionised H20 (3mL). The basic suspension was filtered through celite and extracted into EtOAc (3XL50ML). The combined extracts were dried over MGS04 and the solvent was removed in vacuo. The residue was purified via flash chromatography eluting with MEOH/CH2CL2 (10: 90) to AFFORD 7-METHOXY-1, 2, 3,4-tetrahydro-isoquinoline. This was dissolved in EtOAc (LOML) and hydrogen chloride, 2. 0m solution in Et2O (Aldrich, 45,518-0) (lOmL) was added drop wise, which formed a white ppte. The solid was filtered off and washed with Et20 to afford 7-methoxy-1,2, 3, 4-TETRALLYDRO- isoquinoline hydrochloride as a white solid. Yield 1.4g (42%). HPLC retention time, 3. 05min. Mass spectrum (ES+) m/z 164 (M + H).

As the paragraph descriping shows that 43207-78-9 is playing an increasingly important role.

Reference£º
Patent; IONIX PHARMACEUTICALS LIMITED; WO2005/5392; (2005); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem