As a common heterocyclic compound, it belong tetrahydroisoquinoline compound,6-Methoxy-1,2,3,4-tetrahydroisoquinoline,42923-77-3,Molecular formula: C10H13NO,mainly used in chemical industry, its synthesis route is as follows.,42923-77-3
6-Methoxy-1,2,3,4-tetrahydroisoquinoline (81.6 mg, 0.5 mmol),And a stirrer is placed in the reaction tube,After replacing the inert gas, DMF (193 muL, 2.5 mmol) was added, and the reaction tube was sealed.The reaction tube was placed in a 150 C oil bath reaction pot, and the reaction was stirred for 96 hours;After cooling to room temperature, it was diluted with 15 mL of water and extracted three times with ethyl acetate (15 mL).The combined extracts were dried over anhydrous sodium sulfate and filtered and evaporated.The crude product was subjected to column chromatography using ethyl acetate: petroleum ether = 1:3 (1% triethylamine) as eluent.Yellow solid, mp 63-64 C, yield 74%.
With the synthetic route has been constantly updated, we look forward to future research findings about 6-Methoxy-1,2,3,4-tetrahydroisoquinoline,belong tetrahydroisoquinoline compound
Reference£º
Patent; Xiangtan University; Gong Xing; Yin Jiawen; Cai Changqun; (15 pag.)CN109293569; (2019); A;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem