In an article, published in an article,authors is Bojarski, Andrzej J., once mentioned the application of 33537-99-4, Name is 6-Chloro-1,2,3,4-tetrahydroisoquinoline,molecular formula is C9H10ClN, is a conventional compound. this article was the specific content is as follows. 33537-99-4
Substituted 2-(1,2,3,4-tetrahydroisoquinoline)-butyl derivatives of azaspiro[4.5]decane-7,9-dione and phthalimide as new 5-HT1a and 5-HT2a receptor ligands
Two series of 2-butyl-8-azaspiro[5,4]decane-7,9-dione (a) and N-phthalimidobutyl (b) derivatives of 1,2,3,4-tetrahydroisoquinoline (THIQ) were synthesized. The impact of substituent variations in the aromatic part of the THIQ moiety on 5-HT1A and 5-HT2A receptor affinities, as well as in vivo functional properties of the investigated compounds are discussed. It was found that those modifications improved 5-HT2A receptor affinity, but also slightly reduced the binding affinity for 5-HT1A receptors (in comparison with the unsubstituted THIQ derivatives 3a and 3b). The most active compound (8-Br,5-OCH3-THIQ – 8a) showed features of a 5-HT1A (postsynaptic)/5-HT2A receptor antagonist. Additionally, all chloro derivatives with high and equal affinity for 5-HT1A receptors revealed different functional properties, i.e. an agonistic activity of presynaptic 5-HT1A receptors (4a) and a partial agonistic activity of postsynaptic 5-HT1A receptors (4a, 6a) or an antagonistic activity of postsynaptic ones (5a).
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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem