Author: tianli

Rieth, Thorsten; Tober, Natalie; Limbach, Daniel; Haspel, Tobias; Sperner, Marcel; Schupp, Niklas; Wicker, Philipp; Glang, Stefan; Lehmann, Matthias; Detert, Heiner published an article about the compound: 1-Bromoundecane( cas:693-67-4,SMILESS:CCCCCCCCCCCBr ).Recommanded Product: 1-Bromoundecane. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:693-67-4) through the article.

Tristriazolotriazines with a threefold alkoxyphenyl substitution were prepared and studied by DSC, polarized optical microscopy (POM) and X-ray scattering. Six pentyloxy chains are sufficient to induce liquid-crystalline behavior in these star-shaped compounds Thermotropic properties of tristriazolotriazines with varying substitution patterns and a periphery of linear chains of different lengths, branching in the chain and swallow-tails, are compared. Generally, these disks display broad and stable thermotropic mesophases, with the tangential tristriazolotriazines being superior to the radial isomer. The structure-property relationships of the number of alkyl chains, their position, length and structure were studied.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: Picolinamide. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Discovery of a Potent Picolinamide Antibacterial Active against Clostridioides difficile. Author is Speri, Enrico; Janardhanan, Jeshina; Masitas, Cesar; Schroeder, Valerie A.; Lastochkin, Elena; Wolter, William R.; Fisher, Jed F.; Mobashery, Shahriar; Chang, Mayland.

A major challenge for chemotherapy of bacterial infections is perturbation of the intestinal microbiota. Clostridioides difficile is a Gram-pos. bacterium of the gut that can thrive under this circumstance. Its production of dormant and antibiotic-impervious spores results in chronic disruption of normal gut flora and debilitating diarrhea and intestinal infection. C. difficile is responsible for 12,800 deaths per yr in the United States. Here, we report the discovery of 2-(4-(3-(trifluoromethoxy)phenoxy)picolinamido)benzo[d]oxazole-5-carboxylate as an antibacterial with potent and selective activity against C. difficile. Its MIC50 and MIC90 (the concentration required to inhibit the growth of 50% and 90% of all the tested strains, resp.) values, documented across 101 strains of C. difficile, are 0.12 and 0.25μg/mL, resp. The compound targets cell wall biosynthesis, as assessed by macromol. biosynthesis assays and by SEM. Animals infected with a LD of C. difficile and treated with compound 1 had a similar survival compared to treatment with vancomycin, which is the frontline antibiotic used for C. difficile infection.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Category: tetrahydroisoquinoline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Solvent Dependence of the Monomer-Dimer Equilibrium of Ketone-Substituted Triscatecholate Titanium(IV) Complexes. Author is Kwamen, A. Carel N.; Jenniches, Judith; Oppel, Iris M.; Albrecht, Markus.

Hierarchical helicates based on ketone-substituted titanium(IV)triscatecholates show different monomer-dimer behavior depending on different solvents. The dimerization constants of a whole series of differently alkyl-substituted complexes is analyzed to show that the solvent has a very strong influence on the dimerization. Hereby, effects like solvophobicity/philicity, sterics, electronics of the substituents and weak side-chain-side-chain interactions seem to act in concert.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1452-77-3, is researched, SMILESS is O=C(N)C1=NC=CC=C1, Molecular C6H6N2OJournal, Article, Research Support, Non-U.S. Gov’t, Journal of Inorganic Biochemistry called Characterization of copper(II) specific pyridine containing ligands: Potential metallophores for Alzheimer’s disease therapy, Author is Jakusch, Tamas; Hassoon, Azza A.; Kiss, Tamas, the main research direction is copper zinc pyridinylmethylpicolinamide pyridinylmethylpyridinylmethylamino complex formation ESR; Amyloid β; Copper; Electron Paramagnetic Resonance spectroscopy; Metallophore; Reactive oxygen species; Speciation.Recommanded Product: Picolinamide.

Two amide group containing pyridine derivatives, N-(pyridin-2-ylmethyl)picolinamide (PMPA) and N-(pyridin-2-ylmethyl)-2-((pyridin-2-ylmethyl)amino)acetamide (DPMGA), have been investigated as potential metallo-phores in the therapy of Alzheimer’s disease. Their complex formation with Cu(II) and Zn(II) were characterized in details. Unexpectedly not only the Cu(II) but also the Zn(II) was able to induce deprotonation of the amide-NH, however, it occurred only at higher pH or at higher metal ion concentrations than the biol. conditions. At μM concentration level mono complexes (MLH-1) dominate with both ligands. Direct fluorescence and reactive oxygen species (ROS) producing measurements prove that both ligands are able to remove Cu(II) from its amyloid-β complexes (CuAβ). Correlation was also established between the conditional stability constant of the Cu(II) complexes with different ligands and their ability of inhibition of ROS production by CuAβ.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Density functional theory and surface enhanced Raman spectroscopy characterization of novel platinum drugs, published in 2002, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Recommanded Product: cis-Dichlorobis(pyridine)platinum(II).

There is considerable interest in the development of novel platinum-based anticancer drugs that overcome the disadvantages associated with the widely used drug cisplatin, which are its inactivity against some types of tumors and its toxic side effects. In this study we show the suitability of normal Raman spectroscopy (NRS) and surface enhanced Raman spectroscopy (SERS), assisted by d. functional theor. (DFT) calculations, for the characterization of Pt complexes. The Pt complexes studied include the established drugs cisplatin and carboplatin, as well as five novel Pt complexes with anticancer activity. DFT calculations at the B3LYP/LanL2DZ level are a good prediction of the exptl. NRS spectra of small and medium sized Pt complexes. The use of SERS allows the investigation of Pt complexes at physiol. concentrations, and the binding strengths of the different ligands can be determined The formation of pos. charged hydrolysis products may be necessary for SERS activity. The existing group in the hydrolysis reaction can be identified.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Name: cis-Dichlorobis(pyridine)platinum(II). The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Nucleophilic displacement of the chelating bis(sulfoxide) from cis-[meso-1,2-bis(phenylsulfinyl)ethane]dichloroplatinum(II) and cis-[rac-1,2-bis(phenylsulfinyl)ethane]dichloroplatinum(II). Author is Cattalini, Lucio; Marangoni, Giampaolo; Michelon, Gianni; Paolucci, Gino; Tobe, Martin L..

The kinetics were measured for ring opening of the title Pt complex isomers by amines in 1,2-dimethoxyethane solutions The results are used in a discussion of the differences between the 2 isomers in comparison with other Pt(II) complexes in terms of absolute reactivity, nucleophilic discrimination, and steric retardation effects.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Antitumor and antimitogenic properties of cis-dichloro(dipyridine)platinum(II), the main research direction is platinum dichlordipyridine tumor inhibition; DNA tumor lymphocyte platinum complex; lymphocyte DNA platinum complex; chloropyridines platinum tumor.Reference of cis-Dichlorobis(pyridine)platinum(II).

cis-Dichloro(dipyridine)platinum(II) (I) showed less potent antitumor and antimitogenic activity than previously studied cis-[Pt(NH3)2Cl2] (Rosenberg, B.; Van Camp, L., 1970). However in preliminary experiments, I was also less toxic to mice than the inorganic complex. I inhibited the growth of Escherichia coli. I increased the survival time of mice bearing Ehrlich ascites tumor; in vitro, I also inhibited protein and nucleic acid synthesis by tumors. I inhibited DNA synthesis in phytohemagglutinin-stimulated cultures of human lymphocytes.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Quality Control of cis-Dichlorobis(pyridine)platinum(II). The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Preparation and spectroscopic investigations of platinum complexes. I. Interpretation of the spectra of inverse electron transfer and ligand field transitions of platinum(II) complexes with halide and nitrogen ligands. Author is Textor, M.; Ludwig, W..

Inverse electron-transfer transitions of the type, 5d(Pt) → π(L), were detected in the electronic absorption spectra of cis- and trans-PtL2X2 complexes in which N-containing ligands have an internal π-electron system (L = pyridine, 3- or 4-chloropyridine, 3,5-dichloropyridine, 4-pentyl- or 4-cyanopyridine, or piperidine; X = Cl, Br, or I). In addition to ligand-field (d-d) and ligand π-π* transitions, 3 charge-transfer transitions were distinguished in the spectra of these complexes in CH2Cl2 or cyclohexane solutions Quant. correlation was established between energy of the ligand field transitions and energy of the inverse charge-transfer transitions.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《trans-Dichlorotetrakis(pyridine)platinum(IV) nitrate: a classical coordination compound》. Authors are Seddon, Kenneth R.; Turp, Janet E.; Constable, Edwin C.; Wernberg, Ole.The article about the compound:cis-Dichlorobis(pyridine)platinum(II)cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2).Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II). Through the article, more information about this compound (cas:15227-42-6) is conveyed.

Claims that trans-[PtCl2(py)4](NO3)2 forms a covalent hydrate when dissolved in water are shown to be in error; the observed acidity of the aqueous solution is due to the presence of a small amount of a strongly acidic impurity, and all of the observed phys. and spectroscopic properties of the salt are simply interpreted in terms of classical coordination chem.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Colloid and Interface Science called One-step zwitterionization and quaternization of thick PDMAEMA layer grafted through subsurface-initiated ATRP for robust antibiofouling and antibacterial coating on PDMS, Author is Yu, Xin; Yang, Yang; Yang, Wufang; Wang, Xungai; Liu, Xin; Zhou, Feng; Zhao, Yan, which mentions a compound: 693-67-4, SMILESS is CCCCCCCCCCCBr, Molecular C11H23Br, Reference of 1-Bromoundecane.

In this work, we demonstrate the grafting of thick poly((2-dimethylamino) Et methacrylate) (PDMAEMA) layer on PDMS via subsurface-initiated atom transfer radical polymerization (SSI-ATRP). The self-migration of DMAEMA monomers into the subsurface of PDMS is proven to be the dominant factor for the success of SSI-ATRP. The as-prepared thick microscale graft layer on PDMS shows much better abrasion resistance than nanoscale graft layer obtained by conventional surface-initiated atom transfer radical polymerization (SI-ATRP) under identical condition. Taking advantage of the tertiary amines of PDMAEMA, the simultaneous zwitterionization and quaternization of the PDMAEMA thick layer is realized through a facile one-step process. The effect of zwitterionization and quaternization degree on the antibiofouling and antibacterial properties is investigated. The results show that a relatively high zwitterionization degree (75 mol%) and a low quaternization degree (25 mol%) exhibit a good well-balanced effect on both fouling repellence and bactericidal activity. This work may lead to the development of robust bifunctional antibiofouling and antibacterial surfaces via SSI-ATRP strategy.

Compounds in my other articles are similar to this one(1-Bromoundecane)Reference of 1-Bromoundecane, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem