Category: 1452-77-3

Formula: C6H6N2O. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Picolinamide-Based Iridium Catalysts for Aqueous Formic Acid Dehydrogenation: Increase in Electron Density of Amide N through Substituents. Author is Guo, Jian; Yin, Chengkai; Li, Maoliang; Zhong, Dulin; Zhang, Yuguan; Li, Xiaobin; Wang, Yilin; Yao, Hong; Qi, Tiangui.

Formic acid (FA) is considered to be a potential hydrogen storage material. Homogeneous catalysts are desired, which decompose aqueous FA into H2 and CO2 without addition of organic additives as they can contaminate the generated gas mixture We report a new series of Cp*Ir (Cp*=pentamethylcyclopentadienyl) catalysts featuring picolinamide-based ligands for efficient H2 generation from FA solution Among them in-situ generated catalyst from [Cp*Ir(H2O)3]SO4 and picolinohydroxamic acid (L3) achieved a high turnover frequency (TOF) of 90625 h-1 at 80 °C in 0.9 M FA solution and a turnover number (TON) of 120520 at 80 °C in a recycle experiment The substituent effect of amide N atom was discussed and a plausible mechanism was proposed based on the exptl. results.

The article 《Picolinamide-Based Iridium Catalysts for Aqueous Formic Acid Dehydrogenation: Increase in Electron Density of Amide N through Substituents》 also mentions many details about this compound(1452-77-3)Formula: C6H6N2O, you can pay attention to it, because details determine success or failure

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Tetrahydroisoquinoline – Wikipedia,
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Kumar, Pramod; Kumar, Vijay; Gupta, Rajeev published the article 《Dipicolinamide and isophthalamide based fluorescent chemosensors: Recognition and detection of assorted analytes》. Keywords: dipicolinamide isophthalamide based fluorescent chemosensor review.They researched the compound: Picolinamide( cas:1452-77-3 ).COA of Formula: C6H6N2O. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1452-77-3) here.

A review. This perspective focuses on a variety of fluorescent receptors based on dipicolinamide and isophthalamide groups and their significant roles in the mol. recognition, sensing and detection of assorted analytes ranging from metal ions, anions, neutral mols., drugs and explosives. Both the “”turn-on”” and “”turn-off”” nature of sensing highlights noteworthy applications in many fields encompassing biol., medicinal, environmental and anal. disciplines.

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Tetrahydroisoquinoline – Wikipedia,
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Name: Picolinamide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Synthesis of N-(6-[18F]Fluoropyridin-3-yl)glycine as a potential renal PET agent. Author is Wang, Hongliang; Dong, Weixuan; Zhao, Qinan; Lu, Keyi; Guo, Xiaoshan; Liu, Haiyan; Wu, Zhifang; Li, Sijin.

Given the requirements of high sensitivity and spatial resolution, the development of new positron emission tomog. (PET) agents is required for PET renog. The objective of this study was to investigate a new fluorine-18 labeled hippurate analog of picolinamide, N-(6-[18F]Fluoropyridin-3-yl)glycine, as a new renal PET agent for evaluating renal function. N-(6-[18F]Fluoropyridin-3-yl)glycine was prepared via a two-step reaction, including the nucleophilic substitution reaction of Br with 18F using Me 2-(6-bromonicotinamido)acetate as a precursor followed the hydrolysis with sodium hydroxide and purification by preparative-HPLC. The in vitro and in vivo stability were determined using HPLC, and the plasma protein binding (PPB) and erythrocyte uptake of N-(6-[18F]Fluoropyridin-3-yl)glycine were determined using blood collected from healthy rats at 5 min post-injection. Biodistribution and dynamic micro-PET/CT imaging studies were conducted in healthy rats. N-(6-[18F]Fluoropyridin-3-yl)glycine demonstrated good stability both in vitro and in vivo. The results of the biodistribution and dynamic micro-PET/CT imaging studies in normal rats indicated that N-(6-[18F]Fluoropyridin-3-yl)glycine was rapidly and exclusively excreted via the renal-urinary pathway. N-(6-[18F]Fluoropyridin-3-yl)glycine is has been shown to be a promising renal PET agent and warrants further evaluation of renal function.

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Tetrahydroisoquinoline – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Picolinamide( cas:1452-77-3 ) is researched.Quality Control of Picolinamide.Lee, Cheng-Ting; Tsai, Chang-Che; Wu, Pei-Jhen; Yu, Bor-Yih; Lin, Shiang-Tai published the article 《Screening of CO2 utilization routes from process simulation: Design, optimization, environmental and techno-economic analysis》 about this compound( cas:1452-77-3 ) in Journal of CO2 Utilization. Keywords: carbon dioxide utilization simulation optimization techno economic analysis. Let’s learn more about this compound (cas:1452-77-3).

This work aims at evaluating potential direct CO2 conversion processes through systematic screening and process simulation. Fifteen direct routes converting CO2 to carbonates or carbamates, with in situ chem. dehydration using 2-cyanopyridine (2-CP) are focused. The work covers an extensive examination (and supplement) on the phys. properties, selection of promising routes, process simulation, optimization, environmental, and techno-economic evaluation. Firstly, three promising routes were selected, producing di-Me carbonate (DMC), di-Pr carbonate (DPC), and Iso-Pr N-phenylcarbamate (IPPhCM), based on three criteria: azeotropic search, product selectivity and reacting conditions. Next, the corresponding processes were simulated, optimized, heat-integrated, and systematically compared with the previously-proposed di-Et carbonate (DEC) process through environmental and economic anal. From environmental anal., the CO2 emission rate (CO2-e, in kg/kg-product) was 0.067, 0.088, -0.040 and -0.154 for producing DMC, DPC, IPPhCM and DEC, resp. By reducing the excess ratio used for reaction (i.e. 2-CP/alc. or amine/alc.), the CO2-e improved to -0.122, -0.086, and -0.117 for producing DMC, DPC and IPPhCM, resp. Finally, the min. required selling prices (MRSP) at 15% internal rate of return (IRR) were determined, with the unit price of 2-CP, 2-picolinamide (2-PA), and the reactor residence time regarded as uncertainties. The MRSPs for DMC, DPC, IPPhCM and DEC are found in the range of 1.50-4.96, 2.29-4.24, 2.07-4.06 and 1.12-2.81 (all in USD/kg), resp. Future studies exploring the com. availability and the regeneration of 2-CP, and the feasibility of reducing the excess ratio and the reaction residence time are considered helpful.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Ionic liquid catalysed aerobic oxidative amidation and thioamidation of benzylic amines under neat conditions》. Authors are Joshi, Abhisek; Kumar, Rahul; Semwal, Rashmi; Rawat, Deepa; Adimurthy, Subbarayappa.The article about the compound:Picolinamidecas:1452-77-3,SMILESS:O=C(N)C1=NC=CC=C1).Safety of Picolinamide. Through the article, more information about this compound (cas:1452-77-3) is conveyed.

Tetrabutylammonium hydroxide (TBAOH) was discovered as a highly efficient and green catalyst for aerobic oxidation of the α-methylene carbon of primary amines as well as benzylic groups RCH2NH2 (R = Ph, pyren-1-yl, thiophene-2-yl, etc.) into the corresponding amides RC(O)NH2 and ketones R1C(O)C6H5 [R1 = Ph, pyridin-2-yl, C6H5C(O)] and 9H-fluoren-9-one under neat conditions. Ionic liquid TBAOH catalyzed aerobic oxidation of benzyl amines to benzamides and with elemental sulfur was described; and the corresponding benzylbenzothioamides RC(S)NHCH2R were obtained under metal-free, oxidant-free and base-free conditions. Applicability at the gram scale for the synthesis of the desired amides/ketones is also demonstrated with the present protocol.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Related Products of 1452-77-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Effect of nicotinamide on the flagellar detachment and regeneration of Euglena. Author is Okuwa-Hayashi, Hirotaka; Inui, Hiroshi; Inagaki, Junko; Nakazawa, Masami; Ebara, Shuhei; Enomoto, Toshiki; Sakamoto, Tatsuji; Nakano, Yoshihisa.

Euglena is capable of growth under various variety of nutritional and environmental conditions. Euglena is possible to grow under diverse culture conditions with and without light illumination, namely under both heterotrophic and photoautotrophic conditions. Euglena can synthesize most of vitamins and biofactors except for the exception, such as vitamin B1 and B12. In the present study, the effects of nicotinamide and its analogs on the flagellar detachment of Euglena were investigated using nicotinamide and the 12 kinds of structural analogs (nicotinic acid, pyrazine, pyrazine-2-carboxylic acid, 2-picolinamide, methylnicotinate, N-methylnicotinamide, 3-methylpyridine, pyridine-3-sulfate, pyridoxine, pyridoxal, pyridoxamine, isonicotinic acid hydrazide), NAD+, and NADP+. Among these compounds, nicotinamide, nicotinic acid, pyrazine-2-carboxylic acid, methylnicotinate, 2-picolinamide, and N-methylnicotinamide caused of the flagellar detachment and then cell division stopped. It was also found that nicotinamide added to Euglena cell was dilute with water and culture medium, cell division occurred and then flagella were regenerated after 24h, resulting in onset euglenoid exercise. The electrophoresis of the detached flagellar proteins reveled that the protein resembled tublin (55 kDa) and paraflagella rod 2 (69 KDa).

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1452-77-3, is researched, SMILESS is O=C(N)C1=NC=CC=C1, Molecular C6H6N2OJournal, Journal of Organometallic Chemistry called Design of organoruthenium complexes for nanoparticle functionalization, Author is Kumar, Saawan; Gallician, Guillaume; Weidener, Dennis; Sullivan, Matthew P.; Sohnel, Tilo; Hanif, Muhammad; Hartinger, Christian G., the main research direction is organoruthenium complex design nanoparticle functionalization.Related Products of 1452-77-3.

In recent years, extensive research efforts have been focused on loading metal complexes onto macromol. systems such as nanoparticles. We report a ligand with a catechol group based on a picolinamide which allows for coordination to organoruthenium moieties while the catechol group remains available for loading on nanoparticles as delivery vehicles towards tumors. All the compounds were characterized with standard anal. methods and the mol. structure of the ligand 1, and its Ru complexes 1a and 1b were determined by X-ray diffraction anal. The crystal structure of 1a and 1b showed pseudo-tetrahedral geometry of the Ru center with “”piano-stool”” conformation and 1 coordinated as an N,O-bidentate ligand, however, the latter depending on the reaction conditions employed. The Ru complexes 1a-1c were effectively loaded on magnetite nanoparticles as characterized by inductively-coupled plasma mass spectrometry (ICP-MS), transmission electron microscopy (TEM) and Fourier transform IR spectroscopy (FTIR).

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Reference of Picolinamide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Appraisal of Ruthenium(II) complexes of (4-phenoxyphenylazo) ligands for the synthesis of primary amides by dint of hydroxylamine hydrochloride and aldehydes. Author is Vinoth, Govindasamy; Indira, Sekar; Bharathi, Madheswaran; Sounthararajan, Muniyan; Sakthi, Dharmalingam; Bharathi, Kuppannan Shanmuga.

A new family of O, N donor-functionalized (4-phenoxyphenylazo)-2-naphthol/4-substituted phenol-based ligands (HL1-HL4) has been synthesized. The prepared ligands were successfully utilized for the access of a series of ruthenium(II) carbonyl complexes of the type [Ru(L)Cl(CO)(EPh3)3] (E = phosphine/arsine), (L = 1-(4-phenoxyphenylazo)-2-naphthol (HL1), 2-(4-phenoxyphenylazo)-4-chlorophenol (HL2), 2-(4-phenoxyphenylazo)-4-methylphenol (HL3) and 2-(4-phenoxyphenylazo)-4-methoxyphenol (HL4)). All of the ruthenium(II) carbonyl complexes and ligands have been fully characterized by FT-IR, UV-visible, 1H NMR, 31P NMR, mass spectrometry and CHN anal. The ligands have been analyzed by 13C NMR. The UV-visible spectroscopic study reveals that both the ligands and Ru(II) complexes exhibit excellent charge transfer transitions. This is the basic criteria for the oxidative amidation reaction, which is an influential strategy for the transformation of oxygenated organic compounds to the profitable amides. However, this catalytic process makes more impact on the application of new divalent ruthenium(II) azo compounds as catalyst in a single-pot conversion of aldehydes to amides in the presence of NaHCO3.

Although many compounds look similar to this compound(1452-77-3)Reference of Picolinamide, numerous studies have shown that this compound(SMILES:O=C(N)C1=NC=CC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1452-77-3, is researched, Molecular C6H6N2O, about Silica supported potassium oxide catalyst for dehydration of 2-picolinamide to form 2-cyanopyridine, the main research direction is picolinamide cyanopyridine silica potassium oxide catalyst dehydration.Quality Control of Picolinamide.

The dehydration of 2-picolinamide to produce 2-cyanopyridine was investigated thoroughly using silica supported potassium oxide as a heterogeneous catalyst. Both large sp. surface area and pore size of SiO2 (B) contributed to the favorable catalytic performance for the synthesis of 2-CP. In addition, the yield of 2-CP showed the linear relationship with the amounts of medium basicity of the catalysts, demonstrating that medium basic sites were the active sites of silica supported potassium oxide catalysts. The catalysts were further characterized by XRD and FT-IR to clarify the active species. The results indicated the Si-O-K group produced by the reaction of K2CO3 with Si-OH was the active species, which was further evidenced by the adjustment of the amount of Si-OH by silylation and hydroxylation procedure.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

SDS of cas: 1452-77-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Aqueous-Phase Nitrile Hydration Catalyzed by an In Situ Generated Air-Stable Ruthenium Catalyst. Author is Ounkham, Whalmany L.; Weeden, Jason A.; Frost, Brian J..

RuCl2(PTA)4 (PTA=1,3,5-triaza-7-phosphaadamantane) is an active, recyclable, air-stable, aqueous-phase nitrile hydration catalyst. The development of an in situ generated aqueous-phase nitrile hydration catalyst (RuCl3·3 H2O + 6 equiv PTA) is reported. The activity of the in situ catalyst is comparable to RuCl2(PTA)4. The effects of [PTA] on the activity of the reaction were investigated: the catalytic activity, in general, increases as the pH goes up, which shows a pos. correlation with [PTA]. The pH effects were further explored for both the in situ and RuCl2(PTA)4 catalyzed reaction in phosphate buffer solutions with particular attention given to pH 6.8 buffer. Increased catalytic activity was observed at pH 6.8 vs. water for both systems with turnover frequency (TOF) up to 135 h-1 observed for RuCl2(PTA)4 and 64 h-1 for the in situ catalyst. Catalyst loading down to 0.001 mol % was examined with turnover numbers as high as 22 000 reported. Similar to the preformed catalyst, RuCl2(PTA)4, the in situ catalyst could be recycled more than five times without significant loss of activity from either water or pH 6.8 buffer.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem