Category: 151838-62-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.151838-62-9,2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.,151838-62-9

Example 1 L – (1, 2,3, 4-Tetrahydroisoquinolin-3-ylmethyl)-2, 3-dihydrospiro [indene-1, 4′- piperidine] (A) TERT-BUTYL3- (2, 3-DIHYDRO-1 H-SPIRO [INDENE-1, 4 -PIPERIDIN]-1 -YLCARBONYL)- 3, 4-dihydroisoquinoline-2 (1H)-CARBOXYLATE To a stirred solution of 2- (TERT-BUTOXYCARBONYL)-1, 2,3, 4-tetrahydroisoquinoline-3- carboxylic acid (610.1 mg, 2.2 mmol, this was prepared according to the reported method by S. E. Gibson et al, Bioorg. Med. CHEMLETT., 1997,7, 1289), 2,3- dihydrospiro [LH-INDENE-1, 4′-piperidine] hydrochloride (492.2 mg, 2.2 mmol), triethylamine (0.307 mL, 2.2 mmol), and hydroxybenzotriazole (327 mg, 2.42 mmol) in DMF (15 mL) and THF (10 mL) was added WSC (463.9 mg, 2.42 mmol) at- 20 C. After 2 days stirring at room temperature, the reaction mixture was poured into aqueous NAHCO3 solution (200 mL) and extracted with ether (100 mL x 2). The extracts combined were washed with water (70 mL), dried (MGS04), filtered, and concentrated. The crude product was purified by silica gel column chromatography (n-hexane/ethyl acetate: 2/1) to give 785.8 mg (80 %) of title compound as white solid. 1H NMR (300 MHz, CDC13) 8 7.25-7. 04 (8H, m), 5.47-5. 27 and 5. 08- 4. 73 (total 2H, each m), 4.65-4. 35 and 4.10-3. 90 (total 3H, each m), 3.40-2. 70 (6H, m), 2.18-2. 02 (2H, m), 2.00-1. 40 (13H, m, including 9H, s at 1.49 ppm).

151838-62-9 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 2735649, atetrahydroisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER JAPAN, INC.; PFIZER, Inc.; WO2005/16913; (2005); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

As a common heterocyclic compound, it belong tetrahydroisoquinoline compound,2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,151838-62-9,Molecular formula: C15H19NO4,mainly used in chemical industry, its synthesis route is as follows.,151838-62-9

Example 23 A. Podophyllotoxin-4-O-ester of N-BOC-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid [000302] ; The mixture of podophyllotoxin (20 mg, 0.048 mmol), N-BOC-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (22 mg, 0.07 mmol), EDCI (25 mg, 0.13 mmol), DMAP (2 mg, 0.02 mmol) and dichloromethane (3 ml) were stirred in the room temperature for 20 h, then dichloromethane (20 ml) was added to the solution. Organic layer was washed with water (20 ml), saturated NaHCO3 aqueous solution (10 ml) and brine (20 ml), and then dried over MgSO4. After the solvent was removed under reduced pressure, the resulting liquid was separated by column chromatography (eluent: ethyl acetate and petroleum ether) to afford 15 mgPodophyllotoxin-4-O-ester of N-BOC-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid. [0242] The chemical structure analysis was performed by 1HNMR (CDCl3, 600 MHz):

With the synthetic route has been constantly updated, we look forward to future research findings about 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,belong tetrahydroisoquinoline compound

Reference£º
Patent; Yang, Li-Xi; US2005/4169; (2005); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

151838-62-9, 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2,3-dihydrospiro[indene-1,4?-piperidine] hydrochloride (492.2mg, 2.20mmol), compound 2 (610.1 mg, 2.20 mmol), dry Et3N (307muL, 2.20mmol), and HOBT (327.0mg, 2.42mmol) in dry DMF (15.0mL) and anhydrous THF (10.0mL) was added WSCI (463.9mg, 2.42mmol) at a time at-20C under N2. The resulting mixture was allowed to warm to room temperature, and stirred under N2 for 2 days, and the mixture was turned into yellow solution during the reaction. After some of the solvent were reduced on a rotary evaporator, the residue was poured into aqueous NaHCO3 (200mL) at 0C, and the resulting mixture was extracted with Et2O (100mL¡Á2). The combined extracts were washed with H2O (70mL), dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was purified by column chromatography (silica gel, hexane/AcOEt=2:1) to afford 785.8mg of the title product 17 in 80% yield as a white foamy solid. 1H NMR (300MHz, CDCl3) delta 7.25-7.04 (8H, m), 5.47-5.27 and 5.08-4.73 (total 2H, each m), 4.65-4.35 and 4.10-3.90 (total 3H, each m), 3.40-2.70 (6H, m), 2.18-2.02 (2H, m), 2.00-1.40 (13H, m, including 9H, s at 1.49ppm)

151838-62-9, The synthetic route of 151838-62-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hayashi, Shigeo; Ohashi, Katsuyo; Mihara, Sachiko; Nakata, Eriko; Emoto, Chie; Ohta, Atsuko; European Journal of Medicinal Chemistry; vol. 114; (2016); p. 345 – 364;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, cas is 151838-62-9, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.

To a solution of 2- {4- [2-AMINO-3- (4- FLUOROPHENYL)-PROPIONYL]-3-CYCLOPROPYLMETHYL-2-OXO-PIPERAZIN-1-YL}-N-METHYL-3-NAPHTHALEN-2-YL- propionamide, 18, (44 mg, 0. 068 MMOL) in DMF (1 mL) are added 3, 4-DIHYDRO-1H-ISOQUINOLINE- 2, 3-dicarboxylic acid 2-tert-butyl ester (21 mg, 0.079 MMOL), 1-HYDROXYBENZO-TRIAZOLE (20 mg, 0,148 mmol), N-methylmorpholine (41 mg, 0.41 MMOL) and 1- (3-DIMETHYLAMINO-PROPYL)-3- ETHYLCARBODIIMIDE (16 mg, 0.083 mmol) consecutively. The reaction mixture is stirred for 3 hours, quenched with aqueous NH4CI and extracted several times with ethyl acetate. The combined extracts are dried over NA2SO4, filtered and concentrated in vacuo to a residue, which is purified over silica gel (CH2CI2/CH30H, 13: 1) to afford the desired product.

151838-62-9, As the rapid development of chemical substances, we look forward to future research findings about 151838-62-9

Reference£º
Patent; THE PROCTER & GAMBLE COMPANY; WO2004/37797; (2004); A2;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, cas is 151838-62-9, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.,151838-62-9

To a solution of Boc-Tic-OH (0.33 g, 1.20 mmol) and 2TFAH2N-CH[(CH2)4-NH- Z]-Bid [benzyl 5-amino-5-(lH-benzo[Patent; GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; WO2008/16913; (2008); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, cas is 151838-62-9, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.

The compound (6.27 g) of Example 27 (1) was dissolved in methylene chloride (50 mL), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (6.48 g) and n-pentylamine (3.1 mL) were successively added under ice-cooling, and the mixture was stirred at the same temperature for 1.5 hr. After the reaction mixture was washed successively with 10% aqueous citric acid solution and saturated brine, and dried over sodium sulfate. Then, methylene chloride was evaporated under reduced pressure. The obtained residue was dissolved in formic acid (20 mL), 10M hydrogen chloride – isopropanol solution (6.8 mL) was added under ice-cooling, and the mixture was stirred at the same temperature for 15 min. The reaction mixture was neutralized with saturated aqueous sodium hydrogen carbonate, extracted with ethyl acetate (50 mL), washed with saturated brine, and dried over sodium sulfate. Then, ethyl acetate was evaporated under reduced pressure. The obtained residue was washed with n-hexane, and the precipitate was collected by filtration to give a powder (2.58 g)., 151838-62-9

151838-62-9 is used more and more widely, we look forward to future research findings about 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Reference£º
Patent; Kyoto Pharmaceutical Industries, Ltd.; EP1857444; (2007); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

A common heterocyclic compound, the tetrahydroisoquinoline compound, name is 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,cas is 151838-62-9, mainly used in chemical industry, its synthesis route is as follows.

Step 1 3(R)-Carboethoxy-1,2,3,4-tetrahydroisoquinoline The title compound was obtained from N-Boc-D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Bachem) using standard amino acid chemical procedures.

151838-62-9, As the rapid development of chemical substances, we look forward to future research findings about 151838-62-9

Reference£º
Patent; Merck & Co., Inc.; US5977134; (1999); A;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

151838-62-9, 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Boc-Tic-OH (0.33 g, 1.20 mmol) and 2TFAH2N-CH[(CH2)4-NH- Z]-Bid [benzyl 5-amino-5-(lH-benzo[151838-62-9, As the paragraph descriping shows that 151838-62-9 is playing an increasingly important role.

Reference£º
Patent; GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; WO2008/16913; (2008); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem