Category: 15227-42-6

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Dichlorobis(pyridine)platinum(II)(SMILESS: [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2,cas:15227-42-6) is researched.Quality Control of cis-Dichlorobis(pyridine)platinum(II). The article 《The separation of nonelectrolytic geometric isomers of platinum(II) by thin-layer chromatography》 in relation to this compound, is published in Inorganic Chemistry. Let’s take a look at the latest research on this compound (cas:15227-42-6).

Microscope slides (75 × 25 mm.) were cleaned with detergent, rinsed in H2O, and coated with a slurry containing 1 part Silica Gel G in 3 parts of a 1:1 volume mixture of MeOH and redistilled CH2Cl2. The plates were air dried for 10-20 min. and activated for 1 hr. at 110°. Saturated solutions of the cis isomers, trans isomers, and a 1:1 by weight mixture of both Pt isomers in CH2Cl2 were applied to the plate. The plate was air dried for 2-3 min. and then developed with an ascending technique until the solvent had attained ∼6 cm. The plate was then air dried and the intense yellow-spots detected in a screw-cap jar containing I. The difference of the cis and trans migrations. ΔRf, indicated the effectiveness of separation For [Pt(Et2S)2Cl2] developed in C6H6, CH2Cl2, and 19:1 mixture of C6H6:Me2CO, ΔRf was 0.45, 0.45, and 0.45, resp. For [Pt(Bu3P)2Cl2] developed in C6H6, CH2Cl2, and a 1:1 mixture of C6H6:CH2Cl2 ΔRf was 0.95, 0.55 and 0.80, resp. For [Pt(pyridine)2Cl2] developed in CH2Cl2, 5:1 of C6H6:Me2CO Me2CO, and 5:1 of CH2Cl2:Me2CO ΔRf was 0.20, 0.45, and 0.35 resp. For [(Pr3P)2Pt2(PhS)2Cl2] developed in C6H6 and CH2Cl2 ΔRf was 0.40 and 0.45, resp. For [(Pr3P)2Pt(EtS)2Cl2] developed in CH2Cl2, 1:2 of C6H6:CH2Cl2, and C6H6 ΔRf was 0.40, 0.40, and 0.30, resp. For [Pr3P)2Pt2(p-O2NC6H4S)2Cl2] developed in CH2Cl2 and 2:1 of C6H6:Me2CO ΔRf was 0.30, 0.20, and 0.10, resp. Two (200 × 100 mm.) silica gel plates were prepared A mixture of 100 mg. cis and 100 mg. trans [Cl2Pt(PBu3)2] in CH2Cl2 were applied to the plates and developed with C6H6. The bands at Rf 0.0-0.1 and 0.85-0.10 were removed and eluted with Me2CO and CH2Cl2, resp. Evaporation yielded 91% cis isomer and 93% trans isomer. Thus, complete separation had been achieved with solvent induced isomerization.

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Lucier, Bryan E. G.; Reidel, Alex R.; Schurko, Robert W. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Category: tetrahydroisoquinoline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

Multinuclear solid-state NMR (SSNMR) experiments were performed on cisplatin and four related square-planar compounds The wideband uniform rate smooth truncation-Carr-Purcell-Meiboom-Gill (WURST-CPMG) pulse sequence was used in NMR experiments to acquire 195Pt, 14N, and 35Cl ultra-wideline NMR spectra of high quality. Standard Hahn-echo and magic-angle spinning 195Pt NMR experiments are also performed to refine extracted chem. shielding (CS) tensor parameters. Platinum magnetic shielding (MS) tensor orientations are calculated using both plane-wave d. functional theory (DFT) and standard DFT methods. The tensor orientations are highly constrained by mol. symmetry elements, but also influenced to some degree by intermol. interactions. 14N WURST-CPMG experiments were performed on three compounds and elec. field gradient (EFG) parameters (the quadrupolar coupling constant, Cq, and the asymmetry parameter, ηq) are reported. First principles calculations of the 14N EFG tensor parameters and orientations and affirm their dependence on the local hydrogen bonding environment. 35Cl WURST-CPMG experiments on cisplatin and transplatin are reported, using two different static magnetic fields to extract EFG and CS tensor parameters, and 35Cl EFG tensor magnitudes and orientations are predicted using 1st principles calculations Transverse (T2) relaxation data for all nuclei were used to study heteronuclear dipolar relaxation mechanisms, as well as the nature of the local hydrogen bonding environments.

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Kukushkin, V. Yu.; Tkachuk, V. M. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Formula: C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

[Ph3PCH2Ph]2[PtXCl3] (X = Cl, NO2) are oxidized by Sb(BzCl)Cl5 (I) or Et3NCH2Ph[SbCl6] (II) in MeNO2, MeCN or DMF to give (Ph3PCH2Ph)2[PtXCl5]. SbCl5 oxidizes cis- and trans-Pt(py)2Cl2 to give cis- and trans-[Pt(py)2Cl4], resp. I oxidizes trans-[Pt(NH2CH2CO2H)2Cl2] to give trans-[Pt(NH2CH2CO2H)2Cl4] which on reaction with PCl5 in MeCN gives trans-[Pt(NH2CH2COCl)2Cl4]. [Pt(py)4]Cl2 reacted with I to give trans-[Pt(py)2Cl4]. cis- And trans-[PtL2Cl2] (L = PPh3, SMe2) are not oxidized by I or II.

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Hall, Matthew D.; Daly, Helen L.; Zhang, Jenny Z.; Zhang, Mei; Alderden, Rebecca A.; Pursche, Daniel; Foran, Garry J.; Hambley, Trevor W. published the article 《Quantitative measurement of the reduction of platinum(iv) complexes using X-ray absorption near-edge spectroscopy (XANES)》. Keywords: platinum complex ovarian cancer cytotoxic.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Synthetic Route of C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

The platinum(ii) drugs cisplatin, carboplatin and oxaliplatin are usefully employed against a range of malignancies, but toxicities and resistance have spurred the search for improved analogs. This has included investigation of the platinum(iv) oxidation state, which provides greater kinetic inertness. It is generally accepted that Pt(iv) complexes must be reduced to Pt(ii) for activation. As such, the ability to monitor reduction of Pt(iv) complexes is critical to guiding the design of candidates, and providing mechanistic understanding. Here we report in full that the white line height of X-ray absorption near-edge spectra (XANES) of Pt complexes, normalized to the post-edge min., can be used to quant. determine the proportion of each oxidation state in a mixture A series of Pt(iv) complexes based on the Pt(ii) complexes cisplatin and transplatin were prepared with chlorido, acetato or hydroxido axial ligands, and studies into their reduction potential and cytotoxicity against A2780 human ovarian cancer cells were performed, demonstrating the relationship between reduction potential and cytotoxicity. Anal. of white line height demonstrated a clear and consistent difference between Pt(ii) (1.52 ± 0.05) and Pt(iv) (2.43 ± 0.19) complexes. Reduction of Pt(iv) complexes over time in cell growth media and A2780 cells was observed by XANES, and shown to correspond with their reduction potentials and cytotoxicities. We propose that this method is useful for monitoring reduction of metal-based drug candidates in complex biol. systems.

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Quality Control of cis-Dichlorobis(pyridine)platinum(II). Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Chemical assembling of silica surface using a reaction of catalytic hydrosilylation. Author is Vekki, D. A.; Kuchaev, E. A..

Chem. assembling of the silica surface modified by dimethylchlorosilane was performed by the catalytic hydrosilylation of 1,3-divinyl-1,1,3,3-tetramethyldisiloxane, α-Me styrene, acetophenone, allyl Bu and allyl glycidyl ethers with dimethylchlorosilane. The effect of the nature of complexes of platinum, palladium, rhodium and ruthenium on the parameters of hydrosilylation was studied. It was shown that the maximum rate of hydrosilylation was observed in the reaction with allyl glycidyl ether, and min., with α-methylstyrene; the most effective catalyst of hydrosilylation was [Rh(CO)2(acac)].

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HPLC of Formula: 15227-42-6. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about The investigation of platinum(II) complexes with adenine, adenosine and 2-aminopyrimidines. Author is Stetsenko, A. I.; Dmitrieva, E. S.; Yakovlev, K. I..

[Pt2(NH3)4Cl2L]Cl2 (L = adenine, adenosine) were prepared by the addition of ligand to cis-[Pt(NH3)2Cl2] solution [Pt(NH3)2L](NO3)2 were obtained by adding L to cis-[Pt(NH3)2(H2O)2](NO3)2 solution 2-Aminopyrimidine (L1) and 2-amino-4-phenylpyrimidine (L2) reacted with aqueous K2[PtCl4] to yield trans-[PtL12Cl2] and trans-[PtL22Cl2], resp. The cis-[PtA2L12]Cl2 (A = NH3, pyridine, 0.5 ethylenediamine) were obtained by the substitution reaction of cis-[PtA2Cl2] with 2-aminopyrimidine. The cis-[PtA2(H2O)2](NO3)2 reacted with 2-aminopyrimidine to afford cis-[PtA2L12](NO3)2 and cis-[PtA2L1](NO3)2 (A = NH3, 0.5 ethylenediamine), depending on the stoichiometric ratios of the reactants.

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Synthetic Route of C10H10Cl2N2Pt. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Bis(pentafluorophenyl) complexes of palladium(II) and of platinum(II). Author is Uson, R.; Fornies, J.; Gimeno, J.; Espinet, P.; Navarro, R..

The preparation of 8 bis(pentafluorophenyl) complexes of Pd(II) and of Pt(II) with monodentate and bidentate N-donor ligands is described together with a preparation of a Pd(II) complex of 1,2-bis(diphenylphosphino)ethane. Assignments of cis or trans configuration are discussed which depend upon the splitting or disappearance of certain bands in ir.

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Kukushkin, Yu. N.; Sedova, G. N.; Belyaev, A. N.; Konovalov, L. V. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Formula: C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

The thermal behavior of onium chloroplatinates of the type (AH)2[PtCl6] (A = NH3, MeNH2, 0.5 en, piperidine, py, γ-picoline, NH2Ph, p-toluidine, quinoline, 0.5 2,2′-bipyridine) was studied by derivatog. and IR spectral anal. The heating of solid (AH)2[PtCl6] led to the formation of trans-PtL2Cl4 (L = py, γ-picoline) and cis-PtQ2Cl4 (Q = p-toluidine) and subsequently to the formation of cis-PtA2Cl2. When (AH)2[PtCl6] (A = piperidine) was heated (AH)2[PtCl4] was formed. These results were compared with those for the corresponding palladates.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Activation of the trans geometry in platinum antitumor complexes. Synthesis, characterization, and biological activity of complexes with the planar ligands pyridine, N-methylimidazole, thiazole, and quinoline. Crystal and molecular structure of trans-dichlorobis(thiazole)platinum(II), the main research direction is antitumor platinum chloro nitrogen donor complex; crystal structure platinum chloro thiazole complex.Reference of cis-Dichlorobis(pyridine)platinum(II).

The presence of planar ligands in trans-[PtCl2(py)2] greatly enhances the cytotoxicity of such species, with respect both to their corresponding cis isomer and also to trans-[PtCl2(NH3)2]. The cytotoxicity of trans-[PtCl2(py)2] in murine tumor cell lines is equivalent to the anticancer drug cisplatin, cis-[PtCl2(NH3)2]. The generality of this effect was studied for a range of structures with planar ligands of formula trans-[PtCl2(L)(L’)]. Three distinct series were examined-(1) L = L’ = py, N-methylimidazole (N-MeIm), and thiazole (Tz), (2) L = quinoline (quin), L’ = MeRSO where (R = Me, CH2Ph, Ph), and (3) L = quinoline, L’ = NH3. The synthesis and chem. characterization of all new complexes are described. An x-ray crystal structure determination for trans-[PtCl2(Tz)2] confirmed the geometry with N-bound thiazole. The crystals are monoclinic, space group C2/c, a 8.088(3), b 14.964(4), c 8.847(2) Å, β 99.50(2), Z = 4, R = 0.0545, Rw = 0.0655. Pt has the expected square planar coordination with l(Pt-Cl) = 2.300(5) Å and l(Pt-N) = 2.024(18) and 2.077(17) Å. Bond angles are normal with N(1)-Pt-N(2) = 180.0(1)°, N(1)-Pt-Cl(1) = 90.4(1)°, and N(2)-Pt-Cl(1A) = 89.6(1)°. The intensity data were collected with MoKα radiation with λ = 0.71073 Å. The thiazole rings are not coplanar but slightly tilted to each other at an angle of 14.3°. The dihedral angles between the Pt coordination plane and the thiazole rings are 119.3 and 105.0°. The biol. studies confirm the generality of activation of the trans geometry using planar ligands. Cytotoxicity tests in murine leukemia (L1210) cell lines both sensitive and rendered resistant to cisplatin show that the complexes show equivalent cytostatic activity to that of cisplatin. The activity is an order of magnitude greater than trans-[PtCl2(NH3)2]. The cytotoxicity is further marked by consistent activity in the cisplatin-resistant cell line. Contrary to the well-established but empirical structure-activity relationships, the trans geometry can give platinum complexes with cytotoxicity equivalent to that of the analogous cis isomer. The results point to a further source of platinum antitumor complexes acting by a different mol. mechanism to cisplatin with potential for antitumor activity complementary to that of the clin. used drug.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Article, Chemico-Biological Interactions called Interactions of an antitumor platinum compound with deoxyribonucleic acid, histones, L-amino acids, poly(L-amino acids), nucleosides, and nucleotides, Author is Morris, Carl R.; Gale, Glen R., the main research direction is neoplasm inhibitor platinum compound; DNA platinum compound; amino acid platinum compound; protein platinum compound; nucleic acid component platinum compound.Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II).

The antitumor agents cis-dichloro(dipyridine)platinum(II) [15227-42-6] and cis-dichlorodiammineplatinum(II) [15663-27-1] interacted not only with DNA but also with amino acids, histones, polyamino acids, nucleosides, and nucleotides. The platinum complexes apparently associated with electron-rich areas of the various components. Such interactions could significantly affect pool levels of these cell components, cellular metabolism, and the pharmacol. action of the platinum compounds

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