Category: 15227-42-6

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Reactivity of geometric isomers of (-)-dichloropyridine(methyl p-tolyl sulfoxide)platinum(II) by optical rotatory dispersion, the main research direction is platinum sulfoxide pyridine complex substitution nucleophile; isomerization platinum sulfoxide pyridine complex reaction nucleophile.Safety of cis-Dichlorobis(pyridine)platinum(II).

The reactions of the optically active geometric isomers of (-)-[Pt(Me-p-TolSO)(Py)Cl2] with several nucleophilic reagents (py, Ph3PS, Ph3P, Ph3As, and Me2SO) were studied by ORD, IR spectroscopy, and 1H and 31P NMR spectroscopy. A mechanism for the reaction is proposed.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Article, Research Support, Non-U.S. Gov’t, Chemical Communications (Cambridge, United Kingdom) called Photochemical H2 evolution from water catalyzed by a dichloro(diphenylbipyridine)platinum(II) derivative tethered to multiple viologen acceptors, Author is Kitamoto, Kyoji; Sakai, Ken, the main research direction is photocatalyst hydrogen water dichlorodiphenylbipyridine platinum viologen.Computed Properties of C10H10Cl2N2Pt.

A new single-component photocatalyst for the reduction of water to H2, a dichloro(dpbpy)platinum(II) derivative (dpbpy = 4,4′-diphenyl-2,2′-bipyridine) tethered to four pendant viologen acceptors (1), is shown to exhibit twice higher photocatalytic efficiency than the previously reported dichloro(bpy)-platinum(II) analog (2; bpy = 2,2′-bipyridine), consistent with the higher absorptivity of 1 at the metal-to-ligand charge transfer (1MLCT) band due to the larger π-conjugation in dpbpy relative to bpy.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Palladium(II) and platinum(II) saccharinate complexes containing pyridine and 3-acetylpyridine: Synthesis, crystal structures, fluorescence and thermal properties, the main research direction is preparation palladium platinum saccharinate pyridine acetylpyridine complex; crystal structure palladium platinum saccharinate pyridine acetylpyridine complex; fluorescence platinum saccharinate pyridine acetylpyridine complex.Category: tetrahydroisoquinoline.

New Pd(II) and Pt(II) complexes of saccharinate (sac), trans-[Pd(py)2(sac)2] (1), cis-[Pt(py)2(sac)2] (2), trans-[Pd(3-acpy)2(sac)2] (3) and cis-[Pt(3-acpy)2(sac)2] (4) (py = pyridine and 3-acpy = 3-acetylpyridine) were synthesized. Elemental anal., UV-visible, IR, NMR and TG/DTA characterizations were carried out. The structures of 1-4 were determined by x-ray diffraction. The Pd(II) and Pt(II) ions are coordinated by two N-bonded sac ligands, and two N atoms of py or 3-acpy, forming a distorted square-planar geometry. The Pd(II) complexes (1 and 3) are trans isomers, while the Pt(II) complexes (2 and 4) are cis isomers. The mononuclear species in the solid state are connected by weak intermol. C-H···O H bonds, C-H···π and π···π stacking interactions. The Pt(II) complexes show significant fluorescence at room temperature

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Multistate luminescence, absorption and MCD studies of the relative energies of d → d, d → π*, and n,π → π* transitions for the cis and trans isomers of dichlorobis(pyridine)platinum(II), published in 1983-02-16, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Formula: C10H10Cl2N2Pt.

Luminescence, absorption, and magnetic CD (MCD) experiments are reported for cis- and trans-dichlorobis(pyridine)platinum(II). For the trans isomer, an anal. of the temperature dependence of the lifetimes and luminescence intensities indicates that emission at 605 nm is from 2 excited π* states separated by 240 cm-1. For the cis isomer, time-resolved spectroscopy allowed observation of 2 emission bands at 600 and 700 nm, which were assigned from their lifetimes to π* → d and d → d transitions, resp. Further, temperature dependent lifetime studies show that the 600-nm band (π* → d) is from 2 electronic states separated by 200 cm-1. The absorption spectra of both isomers were measured at room and low temperatures in solution, in glasses, and in KCl pellets. From a comparison with the pyridine and Pt(NH3)2Cl2 absorption and MCD spectra and MO calculations, the observed absorption bands for Pt(py)2Cl2 are assigned as d → d, d → π*, and n, π → π* transitions. For the cis isomer the lowest unoccupied mol. orbital is a d metal orbital.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Antitumor activity of Group VIII transition metal complexes. I. Platinum(II) complexes, published in 1973, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Name: cis-Dichlorobis(pyridine)platinum(II).

A wide variety of Pt(II) complexes were studied for antitumor activity against Sarcoma 180 in female mice. In general only neutral complexes exhibited activity, whereas charged species were inactive and relatively nontoxic. A series of complexes of the type cis-[PtA2X2] (where A2 is either 2 monodentate or 1 bidentate amine ligand and X2 is either 2 monodentate or 1 bidentate anionic ligand) were studied with A and B being systematically varied. At least 10 potentially active antitumor drugs were identified, including cis-dichlorbis(methylamine)platinum(2+) [15273-32-2], diamminepropanedioatoplatinum(2+) [38780-43-7], and (1,2-ethanediammine-N,N’)(2-methylpropanedioato)platinum(2+) [41575-97-7]. The trans isomers were inactive in comparison with active cis complexes, so the presence of cis-reactive ligands seems to be a necessary parameter for antitumor activity. Complexes with highly reactive ligands such as cis-[Pt(NH3)2 (H2O)2](NO3)2 were highly toxic. Pd(II) complexes analogous to the active Pt(II) compounds were themselves inactive.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Thermal isomerization of complex platinum(II) compounds, the main research direction is platinum amine complex isomerization; sulforide platinum complex isomerization; ammine platinum complex isomerization; pyridine platinum complex isomerization.Safety of cis-Dichlorobis(pyridine)platinum(II).

The thermal cis-trans isomerization of [PtA2I2] complexes, where A = NH3, MeNH2, EtNH2, pyridine, was studied by derivatography. The heat of isomerization is 1-7 kcal/mole. trans-[Pt(R2SO)ACl2]-type complexes melt upon heating and isomerize in the melt. The isomerization reaction proceeds through formation of a tetrahedral intermediate.

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Colangelo, Donato; Ghiglia, AnnaLisa; Viano, Ilario; Mahboobi, Homa; Ghezzi, AnnaRita; Cassino, Claudio; Osella, Domenico published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Category: tetrahydroisoquinoline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

Telomerase is a ribonucleoprotein polymerase that synthesizes telomeric DNA (TTAGGG) repeats. Previously, we have studied the effect on telomerase enzyme of several cis-platinum(II) complexes bearing aromatic amines as bulky carrier groups. All these complexes possess cis-geometry, according to the Cleare and Hoschele’s rule. Since recent reports have dealt with the anti-cancer activity of trans-platinum compounds, in this study we have investigated the Farrell’s prototypical trans-[Pt(Cl)2(pyridine)2], hereafter called trans-PtPy, to understand whether it may possess any anti-telomerase activity. The trans-PtPy has low water solubility and requires DMSO as co-solvent, thus making the biol. tests problematic. The effect of trans-PtPy on MCF-7 cell line concerning log-term telomerase inhibition, telomerase-related gene expression, viability, and apoptosis was evaluated. In a cell-free biochem. assay, trans-PtPy showed significant and dose-dependent inhibition of semi-purified telomerase. The bulk of data indicate that trans-PtPy acts as a non-properly selective anti-proliferative agent, although it shows an initial telomerase inhibitory effect. Telomere length reduction seems not to be the main mechanism causing the observed cell apoptosis. For comparison purpose, results on cis-[Pt(Cl)2(pyridine)2] are reported.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Iyo Masu Kenkyukai Koenshu called Mass spectrometry of cis-platin in urine, Author is Sumino, Kimiaki; Mio, Takaya; Yamamoto, Ryoji; Ishigami, Joji; Kamidono, Sadao; Hamami, Gaku, which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Electric Literature of C10H10Cl2N2Pt.

The mass spectra of cisplatin  [15663-27-1] and its analogs are presented. A urine sample of a cancer patient treated with cisplatin was extracted with 0.1N-HCl and then washed with COMe2/CHCl3. The component containing Pt was eluted with 2N-HBr using an ion exchange chromatog. technique. The mass spectrum of the component showed the change from Cl-type to Br-type as the unchanged type of carrier ligand. Thus, mass spectrometry may be a useful method to elucidate the action mechanism of cisplatin.

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Kong, Pi-Chang; Rochon, F. D. published the article 《Reactions of potassium tetrachloroplatinate(II) with pyridine derivatives in dimethylformamide and synthesis of potassium trichloro(pyridine)platinum(II)》. Keywords: platinum pyridine derivative complex; picoline platinum complex; lutidine platinum complex.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Name: cis-Dichlorobis(pyridine)platinum(II). Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

The reactions of K2PtCl4 with pyridine derivatives L (L = py = pyridine, pic = picoline, and lut = lutidine) were studied in DMF. K[PtLCl3] (I) were isolated and the yield decreased with the order, 2,4-lut = 2-pic > 2,6-lut > 4-pic = py, which can be correlated to the steric hindrance of the ortho Me groups. Cis-[PtL2Cl2] (II) is the final product of the reactions. Trans-[PtL2Cl2] (III) can also be obtained from a DMF solution of [Pt(L)4]Cl2 (L = py) at room temperature A comparison of the above reactions in H2O and in DMF was also made.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Rearrangement of a platinum(II) complex in DNA from intercalation outer-sphere position to non-intercalation coordination, the main research direction is DNA interaction platinum dipyridine complex.Recommanded Product: cis-Dichlorobis(pyridine)platinum(II).

The interaction of I with DNA was studied using linear dichroism and absorption spectra of DNA solutions containing different concentrations of I. The initial complex had a stability constant of 3 × 105M-1 and the orientation of the I plane was angular, indicating that binding was by intercalation. This intercalated complex slowly transformed into a more stable complex with the orientation of the I plane parallel to the helix axis. In this complex there was coordination of I to N atoms of DNA bases. This complex involved the inner sphere of DNA. When II interacted with DNA, a complex was formed in which inner sphere coordination was present; II did not intercalate with DNA.

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