Category: 15227-42-6

Electric Literature of C10H10Cl2N2Pt. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Platinum(II) complexes in the catalytic hydrosilylation of acetophenone. Kinetics of the reaction and the effect of ligands. Author is Lasitsa, N. A.; Skvortsov, N. K.; Lobadyuk, V. I.; Spevak, V. N.; Esina, G. A.; Abramova, I. P.; Lazarev, S. Ya..

A kinetic study of hydrosilylation of MeCOPh with MeSiHCl2 or MeSiPhH2 in the presence of LL1PtX2 (X = Cl, Br; L = L1 = Me2SO, Et2SO, py, Et3P, MeSOC6H4Me-4; L = C2H4, L1 = Me2SO, Et2SO; L = py, L1 = Et2SO; L = MeSOC6H4Me-4, L1 = Bu3P) catalysts showed a relationship between the ligand type and catalytic activity. In contrast with bis(phosphine) and bis(olefin) complexes, bis(sulfoxide) complexes and all complexes with mixed ligands, one of which is sulfoxide, show high catalytic activity. For the reaction with MeSiHCl2, the order of reactivity is olefin > SO > P(III) > py, close to an analogous relationship for the hydrosilylation of olefins.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Canadian Journal of Chemistry called Multinuclear solid-state NMR of square-planar platinum complexes – Cisplatin and related systems, Author is Lucier, Bryan E. G.; Reidel, Alex R.; Schurko, Robert W., the main research direction is platinum complex solid state NMR.HPLC of Formula: 15227-42-6.

Multinuclear solid-state NMR (SSNMR) experiments were performed on cisplatin and four related square-planar compounds The wideband uniform rate smooth truncation-Carr-Purcell-Meiboom-Gill (WURST-CPMG) pulse sequence was used in NMR experiments to acquire 195Pt, 14N, and 35Cl ultra-wideline NMR spectra of high quality. Standard Hahn-echo and magic-angle spinning 195Pt NMR experiments are also performed to refine extracted chem. shielding (CS) tensor parameters. Platinum magnetic shielding (MS) tensor orientations are calculated using both plane-wave d. functional theory (DFT) and standard DFT methods. The tensor orientations are highly constrained by mol. symmetry elements, but also influenced to some degree by intermol. interactions. 14N WURST-CPMG experiments were performed on three compounds and elec. field gradient (EFG) parameters (the quadrupolar coupling constant, Cq, and the asymmetry parameter, ηq) are reported. First principles calculations of the 14N EFG tensor parameters and orientations and affirm their dependence on the local hydrogen bonding environment. 35Cl WURST-CPMG experiments on cisplatin and transplatin are reported, using two different static magnetic fields to extract EFG and CS tensor parameters, and 35Cl EFG tensor magnitudes and orientations are predicted using 1st principles calculations Transverse (T2) relaxation data for all nuclei were used to study heteronuclear dipolar relaxation mechanisms, as well as the nature of the local hydrogen bonding environments.

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COA of Formula: C10H10Cl2N2Pt. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Novel platinum pyridine-hydroxamic acid complexes: Synthesis, characterization, X-ray crystallographic study and nitric oxide related properties. Author is Griffith, Darren; Bergamo, Alberta; Pin, Sara; Vadori, Marta; Mueller-Bunz, Helge; Sava, Gianni; Marmion, Celine J..

We describe the synthesis and characterization of a novel class of PtII and PtIV pyridine-hydroxamic acid (pyhaH) complexes of general formula cis-[PtIICl2(x-pyhaH)2] and cis-[PtIVCl4(x-pyhaH)2], resp., (where x = 3 or 4) in which the pyridine-hydroxamic acid is coordinated to the platinum ion via the pyridine nitrogen only leaving the hydroxamic acid free to potentially release cytotoxic nitric oxide (NO). The crystal structure of the PtIV derivative, cis-[PtCl4(4-pyhaH)2]·2CH3OH is reported. To establish the biol. effect of the uncoordinated hydroxamic acid moiety in the PtII compounds, the corresponding pyridinecarboxylic acid (pycaH) complexes of general formula cis-[PtIICl2(x-pycaH)2] (where x = 3 or 4) and the PtII pyridine (py) complex cis-[PtIICl2(py)2] were synthesized and served as reference standards The NO-releasing properties of each of the PtII compounds, the pyhaH and the pycaH ligands were studied. The PtII pyridine-hydroxamic acid derivatives were found to induce potent in vitro effects attributable to either NO-release from the hydroxamic acid moiety and/or stimulation of inducible nitric oxide synthase of endothelial cells.

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Tetrahydroisoquinoline – Wikipedia,
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Electric Literature of C10H10Cl2N2Pt. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Chemical assembling of silica surface using a reaction of catalytic hydrosilylation. Author is Vekki, D. A.; Kuchaev, E. A..

Chem. assembling of the silica surface modified by dimethylchlorosilane was performed by the catalytic hydrosilylation of 1,3-divinyl-1,1,3,3-tetramethyldisiloxane, α-Me styrene, acetophenone, allyl Bu and allyl glycidyl ethers with dimethylchlorosilane. The effect of the nature of complexes of platinum, palladium, rhodium and ruthenium on the parameters of hydrosilylation was studied. It was shown that the maximum rate of hydrosilylation was observed in the reaction with allyl glycidyl ether, and min., with α-methylstyrene; the most effective catalyst of hydrosilylation was [Rh(CO)2(acac)].

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Quality Control of cis-Dichlorobis(pyridine)platinum(II).Kotowski, M.; Palmer, D. A.; Kelm, H. published the article 《Volumes of activation for the substitution reactions of cis- and trans-[PtL2(Cl)X] with pyridine in various solvents》 about this compound( cas:15227-42-6 ) in Inorganic Chemistry. Keywords: platinum complex substitution kinetics pyridine; volume activation platinum complex substitution; solvent effect platinum complex substitution. Let’s learn more about this compound (cas:15227-42-6).

The pressure dependence of the 2nd-order rate constant for the substitution of pyridine for Cl in trans-[Pt(py)2(Cl)(NO2)] was measured in the solvents nitromethane, methanol, ethanol, and dichloromethane. The resp. ΔV*exptl. values were calculated to be -6.2 ± 0.4 at 10°, -8.8 ± 0.6 at 25°, -13.1 ± 0.8 at 25°, and -19.8 ± 1.7 cm3 mol-1 att 25°. The ΔVexptl. values for the corresponding reactions of cis-[Pt(py)2(Cl)(NO2)] and trans-[Pt(PEt3)2Cl2] in methanol at 25° are -5.5 ± 0.5 and -13.6 ± 0.8 cm3 mol-1, resp. These ΔV*exptl.’s were found to be only slightly temperature dependent. The activation parameters ΔH*2 and ΔS*2 were also determined for each reaction. The volume change associated with the partial formation of the Pt-pyridine bond was estimated to be -4 ± 1 cm3 mol-1. A qual. explanation of the solvent dependence of ΔV*exptl. is also given.

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Tetrahydroisoquinoline – Wikipedia,
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Vekki, D. A.; Skvortsov, N. K. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Category: tetrahydroisoquinoline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

Reaction of α-methylstyrene with 1,1,3,3-tetramethyldisiloxane in the presence of the complexes of Pt(II), Pd(II) and Rh(I) is explored. In the presence of Pt catalyst, hydrosilylation of α-methylstyrene occurs predominantly giving β-adduct, while on Pd catalysts proceeds reduction of α-methylstyrene and on Rh catalysts both processes take place. In the reaction mixture proceeds disproportion and dehydro-condensation of 1,1,3,3-tetramethyldisiloxane that gives long chain linear and cyclic siloxanes HMe2Si(OSiMe2)nH and (-OSiMe2-)m (n = 2-6, m = 3-7), resp. Platinum catalysts promotes formation of linear siloxanes, while both Rh and Pd catalysts afford linear and cyclic siloxanes as well. Structure of intermediate metallo-complexes was studied.

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Tetrahydroisoquinoline – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Dichlorobis(pyridine)platinum(II)(SMILESS: [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2,cas:15227-42-6) is researched.Category: tetrahydroisoquinoline. The article 《Cytostatic trans-platinum(II) complexes》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:15227-42-6).

The unusual cytostatic properties of trans-Pt(II) complexes of pyridine, trans-[PtCl2L2] (L = pyridine, 4-methylpyridine), are reported. The complexes demonstrate increased cytostatic activity to L1210 leukemia cells over the cis-pyridine analogs and had activity equivalent to that of cisplatin. The results have implications for the design of structurally novel Pt antitumor agents.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Article, Research Support, Non-U.S. Gov’t, Journal of Inorganic Biochemistry called Might telomerase enzyme be a possible target for trans-Pt(II) complexes?, Author is Colangelo, Donato; Ghiglia, AnnaLisa; Viano, Ilario; Mahboobi, Homa; Ghezzi, AnnaRita; Cassino, Claudio; Osella, Domenico, the main research direction is trans platinum antitumor complex telomerase target.Product Details of 15227-42-6.

Telomerase is a ribonucleoprotein polymerase that synthesizes telomeric DNA (TTAGGG) repeats. Previously, we have studied the effect on telomerase enzyme of several cis-platinum(II) complexes bearing aromatic amines as bulky carrier groups. All these complexes possess cis-geometry, according to the Cleare and Hoschele’s rule. Since recent reports have dealt with the anti-cancer activity of trans-platinum compounds, in this study we have investigated the Farrell’s prototypical trans-[Pt(Cl)2(pyridine)2], hereafter called trans-PtPy, to understand whether it may possess any anti-telomerase activity. The trans-PtPy has low water solubility and requires DMSO as co-solvent, thus making the biol. tests problematic. The effect of trans-PtPy on MCF-7 cell line concerning log-term telomerase inhibition, telomerase-related gene expression, viability, and apoptosis was evaluated. In a cell-free biochem. assay, trans-PtPy showed significant and dose-dependent inhibition of semi-purified telomerase. The bulk of data indicate that trans-PtPy acts as a non-properly selective anti-proliferative agent, although it shows an initial telomerase inhibitory effect. Telomere length reduction seems not to be the main mechanism causing the observed cell apoptosis. For comparison purpose, results on cis-[Pt(Cl)2(pyridine)2] are reported.

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Safety of cis-Dichlorobis(pyridine)platinum(II). So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Experimental criteria for the applicability of the group model to stretching vibrations of the dichloroplatinum fragment in square planar complexes.

A correlation was found between the Pt-Cl bond length difference, Δr, and the distance, Δν, between the doublet components of the stretching vibration νClPt in cis[PtCl2LL’] complexes with 2 different ligands, L and L’. For Δr = 0-0.025 Å, a constant splitting Δν = 15-25 cm-1 was observed, but for Δr >0.03 Å Δν increased linearly with increasing Δr. The difference was explained in terms of sym. and asym. Pt-Cl bonds.

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Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II). Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about The effects of single administration of an antitumor platinum compound on ornithine decarboxylase activity in certain tissues of mice bearing L1210 leukemia. Author is Morris, Carl R.; Atkins, Loretta M.; Gale, Glen R..

A single dose of cis-dichloro(dipyridine)platinum(II) [15227-42-6], when given to mice bearing 1-day-old L1210 leukemia, suppressed the increase of spleen and liver ornithine decarboxylase (ODC) [9024-60-6] activity which occurs concomitantly with development of the leukemia. The inhibition of ODC, the rate-limiting enzyme in polyamine synthesis, appeared to correlate with the prolonged chemotherapeutic efficacy of a single dose of the platinum complex. These observations suggest an addnl. mechanism by which platinum complexes express their antitumor actions and, in addition, support the view that polyamine synthesis and excretion patterns can be used as predictors of chemotherapeutic response.

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Tetrahydroisoquinoline – Wikipedia,
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