Category: 15227-42-6

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Related Products of 15227-42-6.Howle, Jerry A.; Gale, Glen R.; Smith, Alayne B. published the article 《Proposed mode of action of antitumor platinum compounds based upon studies with cis-dichloro([G-3H]-dipyridine)platinum(II)》 about this compound( cas:15227-42-6 ) in Biochemical Pharmacology. Keywords: chloropyridine platinum tumor; DNA dichlorodipyridine platinum; erythrocyte dichlorodipyridine platinum; RNA dichlorodipyridine platinum. Let’s learn more about this compound (cas:15227-42-6).

The antitumor and antimitotic action of the pyridine-tritiated square-planar Pt complex cis-dichloro(dipyridine)platinum(II) (I) [15227-42-6] seems to depend on the dissociation of 1 or both chlorine atoms from the platinum atom. The resulting cationic, aquated species subsequently forms a bond with nucleic acid. I associate avidly with calf thymus DNA, high mol. weight yeast RNA, and bacterial and yeast tRNA, but not with bovine serum albumin, dextran, or purified erythrocyte membranes. Dialysis of the Pt-nucleic acid complexes in distilled water or NaCl results in loss of a portion of the original radioactivity. The Pt-DNA bond is resistant to dissociation by solubilization in alkali followed by trichloroacetic acid (TCA) precipitation Bonding of I to DNA in vitro is inhibited by NaCl; however, prior alkylation of the DNA with nitrogen mustard does not influence its subsequent bonding with I. I associate with intact Ehrlich ascites tumor cells in vitro at 2.deg. and 37.deg. and resists dissociation by washing with saline or TCA as well as solubilization in alkali followed by re-precipitation with TCA.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Dichlorobis(pyridine)platinum(II)(SMILESS: [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2,cas:15227-42-6) is researched.Related Products of 1452-77-3. The article 《Experimental and theoretical study of the cytotoxic activity of new tetrazole-containing cisplatin analogues and their trans-isomers》 in relation to this compound, is published in Doklady Natsional’noi Akademii Nauk Belarusi. Let’s take a look at the latest research on this compound (cas:15227-42-6).

Quantum chem. calculations within the framework of DFT were carried out for a set of platinum (II) complexes with nitrogen-containing heterocycles. A phys. interpretable QSAR model was developed and a correlation between the biol. activity and structural properties was obtained by means of the multiple linear regression method. The range of new tetrazole-containing platinum (II) complexes was synthesized, and their cytotoxic activity was exptl. determined and compared with the values predicted by the QSAR model. Crucial properties of compounds and their relationship with the mode of action were discussed.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Preparation and spectroscopic investigations of platinum complexes. I. Interpretation of the spectra of inverse electron transfer and ligand field transitions of platinum(II) complexes with halide and nitrogen ligands, the main research direction is platinum inverse charge transfer; halide pyridine platinum UV.Category: tetrahydroisoquinoline.

Inverse electron-transfer transitions of the type, 5d(Pt) → π(L), were detected in the electronic absorption spectra of cis- and trans-PtL2X2 complexes in which N-containing ligands have an internal π-electron system (L = pyridine, 3- or 4-chloropyridine, 3,5-dichloropyridine, 4-pentyl- or 4-cyanopyridine, or piperidine; X = Cl, Br, or I). In addition to ligand-field (d-d) and ligand π-π* transitions, 3 charge-transfer transitions were distinguished in the spectra of these complexes in CH2Cl2 or cyclohexane solutions Quant. correlation was established between energy of the ligand field transitions and energy of the inverse charge-transfer transitions.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Inorganic Chemistry called Activation of the trans geometry in platinum antitumor complexes. Synthesis, characterization, and biological activity of complexes with the planar ligands pyridine, N-methylimidazole, thiazole, and quinoline. Crystal and molecular structure of trans-dichlorobis(thiazole)platinum(II), Author is Van Beusichem, Marijo; Farrell, Nicholas, the main research direction is antitumor platinum chloro nitrogen donor complex; crystal structure platinum chloro thiazole complex.Recommanded Product: cis-Dichlorobis(pyridine)platinum(II).

The presence of planar ligands in trans-[PtCl2(py)2] greatly enhances the cytotoxicity of such species, with respect both to their corresponding cis isomer and also to trans-[PtCl2(NH3)2]. The cytotoxicity of trans-[PtCl2(py)2] in murine tumor cell lines is equivalent to the anticancer drug cisplatin, cis-[PtCl2(NH3)2]. The generality of this effect was studied for a range of structures with planar ligands of formula trans-[PtCl2(L)(L’)]. Three distinct series were examined-(1) L = L’ = py, N-methylimidazole (N-MeIm), and thiazole (Tz), (2) L = quinoline (quin), L’ = MeRSO where (R = Me, CH2Ph, Ph), and (3) L = quinoline, L’ = NH3. The synthesis and chem. characterization of all new complexes are described. An x-ray crystal structure determination for trans-[PtCl2(Tz)2] confirmed the geometry with N-bound thiazole. The crystals are monoclinic, space group C2/c, a 8.088(3), b 14.964(4), c 8.847(2) Å, β 99.50(2), Z = 4, R = 0.0545, Rw = 0.0655. Pt has the expected square planar coordination with l(Pt-Cl) = 2.300(5) Å and l(Pt-N) = 2.024(18) and 2.077(17) Å. Bond angles are normal with N(1)-Pt-N(2) = 180.0(1)°, N(1)-Pt-Cl(1) = 90.4(1)°, and N(2)-Pt-Cl(1A) = 89.6(1)°. The intensity data were collected with MoKα radiation with λ = 0.71073 Å. The thiazole rings are not coplanar but slightly tilted to each other at an angle of 14.3°. The dihedral angles between the Pt coordination plane and the thiazole rings are 119.3 and 105.0°. The biol. studies confirm the generality of activation of the trans geometry using planar ligands. Cytotoxicity tests in murine leukemia (L1210) cell lines both sensitive and rendered resistant to cisplatin show that the complexes show equivalent cytostatic activity to that of cisplatin. The activity is an order of magnitude greater than trans-[PtCl2(NH3)2]. The cytotoxicity is further marked by consistent activity in the cisplatin-resistant cell line. Contrary to the well-established but empirical structure-activity relationships, the trans geometry can give platinum complexes with cytotoxicity equivalent to that of the analogous cis isomer. The results point to a further source of platinum antitumor complexes acting by a different mol. mechanism to cisplatin with potential for antitumor activity complementary to that of the clin. used drug.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: 15227-42-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Synthesis, characterization and cytotoxicity of some palladium(II), platinum(II), rhodium(I) and iridium(I) complexes of ferrocenylpyridine and related ligands. Crystal and molecular structure of trans-dichlorobis(3-ferrocenylpyridine)palladium(II). Author is Rajput, Jaisheila; Moss, John R.; Hutton, Alan T.; Hendricks, Denver T.; Arendse, Catherine E.; Imrie, Christopher.

The preparation of a series of ferrocenyl nitrogen donor ligands including ferrocenylpyridines, ferrocenylphenylpyridines and 1,1′-di(2-pyridyl)ferrocene is described. Coordination studies of the substituted pyridines (L) were carried out with platinum, palladium, rhodium and iridium. This resulted in the preparation of the following types of complexes: [MCl(CO)2(L)] and [M(cod)(L)2]ClO4 where M = Rh or Ir, cod = 1,5-cyclooctadiene; [M’Cl2(L)2] where M’ = Pt or Pd. The X-ray crystal structure of trans-dichlorobis(3-ferrocenylpyridine)palladium was obtained. The complexes were screened for activity against two human cancer cell lines. At least two of the complexes displayed growth inhibition similar to that of the widely used chemotherapeutic agent, cisplatin.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Platinum compounds with anti-tumor activity, the main research direction is platinum compound tumor structure; platinum compound antitumor structure.Application of 15227-42-6.

Ten Pt coordination complexes with different ligands, comprising both Pt(II) and Pt(IV) complexes of which the cis-compounds all possessed at least some antitumor activity and the trans-compounds were inactive, were tested as to their effect on cell survival and the induction and repair of DNA damage in cultured Chinese hamster cells (CHO). The Pt-compounds were divided in 3 groups on the basis of their cytotoxicity. The compounds with high cytotoxicity were also active antitumor drugs, but a clear correlation between cytotoxicity and antitumor activity was not observed All compounds inhibited semi-conservative DNA synthesis and induced DNA repair replication. No induction of DNA single strand breaks and DNA cross-links was detected. However, the occurrence of alkali labile sites in the DNA of treated CHO cells demonstrated the induction of unidentified DNA bases damages. The cis-compounds were more mutagenic than the trans-compounds

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Product Details of 15227-42-6. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Antitumor and antimitogenic properties of cis-dichloro(dipyridine)platinum(II). Author is Gale, Glen R.; Howle, Jerry A.; Walker, Ernest M. Jr..

cis-Dichloro(dipyridine)platinum(II) (I) showed less potent antitumor and antimitogenic activity than previously studied cis-[Pt(NH3)2Cl2] (Rosenberg, B.; Van Camp, L., 1970). However in preliminary experiments, I was also less toxic to mice than the inorganic complex. I inhibited the growth of Escherichia coli. I increased the survival time of mice bearing Ehrlich ascites tumor; in vitro, I also inhibited protein and nucleic acid synthesis by tumors. I inhibited DNA synthesis in phytohemagglutinin-stimulated cultures of human lymphocytes.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis, Characterization, and Reactivity of trans-[PtCl(R’R”SO)(A)2]NO3 (R’R”SO = Me2SO, MeBzSO, MePhSO; A = NH3, py, pic). Crystal Structure of trans-[PtCl(Me2SO)(py)2]+, published in 2001-04-09, which mentions a compound: 15227-42-6, mainly applied to crystal structure platinum dimethyl sulfoxide pyridine chloro; ammine effect sulfoxide reactivity trans platinum complex; pyridine effect sulfoxide reactivity trans platinum complex; sulfoxide substitution platinum complex kinetics; nucleotide platinum amine complex preparation; platinum sulfoxide complex preparation substitution ammine pyridine effect, Electric Literature of C10H10Cl2N2Pt.

Trans complexes such as trans-[PtCl2(NH3)2] have historically been considered therapeutically inactive. The use of planar ligands such as pyridine greatly enhances the cytotoxicity of the trans geometry. Trans-[PtCl(R’R”SO)(A)2]NO3 (R’R”SO = substituted sulfoxides such as di-Me (Me2SO), Me benzyl (MeBzSO), and Me Ph sulfoxide (MePhSO) and A = NH3, pyridine (py) and 4-methylpyridine or picoline (pic)) were prepared for comparison of the chem. reactivity between ammine and pyridine ligands. The x-ray crystal structure determination for trans-[PtCl(Me2SO)(py)2]NO3 confirmed the geometry with S-bound Me2SO. The crystals are orthorhombic, space group P212121, with a 7.888(2), b 14.740(3), c 15.626(5) Å, and Z = 4. The geometry around the Pt atom is square planar with l(Pt-Cl) = 2.304(4) Å, l(Pt-S) = 2.218(5) Å, and l(Pt-N) = 2.03(1) and 2.02(1) Å. Bond angles are normal with Cl-Pt-S = 177.9(2)°, Cl-Pt-N1 = 88.0(4)°, Cl-Pt-N2 = 89.3(5)°, S-Pt-N1 = 93.8(4)°, S-Pt-N2 = 88.9(4)°, and N1-Pt-N2 = 177.2(6)°. The intensity data were collected with Mo Kα radiation with λ = 0.71069 Å. Refinement was by full-matrix least-squares methods to a final R value of 3.80%. Unlike trans-[PtCl2(NH3)2], trans-[PtCl2(A)2] (A = py or pic) complexes do not react with Me2SO. The solvolytic products of cis-[PtCl2(A)2] (A = py or pic) were characterized. Studies of displacement of the sulfoxide by chloride were performed using HPLC. The sulfoxide was displaced faster for the pyridine complex relative to the ammine complex. Chem. studies comparing the reactivity of trans-[PtCl(R’R”SO)(amine)2]NO3 with a model nucleotide, GMP, showed that the reaction gave two principal products: [Pt(R’R”SO)(amine)2(N7-GMP)], which reacts with a second equivalent of GMP, forming [Pt(amine)2(N7-GMP)2]. The reaction pathways were different, however, for the pyridine complexes in comparison to the NH3 species, with sulfoxide displacement again being significantly faster for the pyridine case.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Kukushkin, Yu. N.; Sedova, G. N.; Belyaev, A. N. published the article 《Thermal migration of amines in platinum(II) complexes》. Keywords: platinum complex amine thermal migration; ammine thermal migration platinum complex; pyridine thermal migration platinum complex; methylamine thermal migration platinum complex; ethylenediamine thermal migration platinum complex; aniline thermal migration platinum complex; quinoline thermal migration platinum complex; picoline thermal migration platinum complex; toluidine thermal migration platinum complex; piperidine thermal migration platinum complex; hydroxyquinoline thermal migration platinum complex.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).COA of Formula: C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

Derivatog. data indicate that the 1st stage of the thermal conversion of (LH)2[PtCl4] (L = NH3, MeNH2, piperidine, pyridine, γ-picoline, PhNH2, p-toluidine, 8-hydroxyquinoline, quinoline) or (enH2)[PtCl4] is the cleavage of HCl and the formation of PtL2Cl2. All the complexes studied fall into 2 groups according to the temperature of the beginning of the process: (1) complexes with a temperature for the start of thermal reaction at 180 – 200° contain amines the basicity constants of which are >10-5 and (2) complexes with decomposition temperatures at 130-50° contain amines the basicity constants of which are <10-8. There are many compounds similar to this compound(15227-42-6)COA of Formula: C10H10Cl2N2Pt. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Spectra and structure of pyridine coordination compounds》. Authors are Herbelin, F.; Herbelin, J. D.; Mathieu, J. P.; Poulet, H..The article about the compound:cis-Dichlorobis(pyridine)platinum(II)cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2).Recommanded Product: cis-Dichlorobis(pyridine)platinum(II). Through the article, more information about this compound (cas:15227-42-6) is conveyed.

Ir absorption spectra of 15 coordination compounds of pyridine with Pt, Rh, and Ir have been observed, 100-3200 cm.-1; in some cases uv and Raman spectra have also been observed. The effect of coordination on the vibration spectrum of pyridine, the structure of the coordinated units, and the differences in the spectra of cis-trans isomers are discussed.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem