Category: 15227-42-6

Synthetic Route of C10H10Cl2N2Pt. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Mass spectrometry of platinum(II) complexes. Comparison of cis and trans isomers. Fragmentation and rearrangement pathways. Author is Haake, P.; Mastin, S. H..

The mass spectra of 8 pairs of cis and trans isomers of PtL2X2 (L=NH3, pyridine PEt3, or PPh3; X=Cl, Br, or I) are presented and discussed. Two chelates, Pt(bipy)Cl2 and Pt(dpm)Cl2(dpm=di-α-pyridylmethane), are also included. The most significant results are: (1) parent ions can be observed for almost all these relatively involatile coordination compounds; (2) most ligand fragmentations and rearrangements occur with ligand-metal bonds intact; (3) some rearrangements appear to involve the metal; (4) cis and trans isomers of phosphine complexes give different fragmentation patterns; (5) spectra of chelates differ considerably from the spectra of analogous nonchelates; (6) in Pt(NH3)2Cl2 and Pt(py)2Cl2, little or no difference is observed in the spectra of cis and trans isomers after electron impact. Therefore, excitation to a tetrahedral state may take place.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Interaction of cis platinum(II) compounds with poly(L-glutamate). A doubly anchored spin-label and a doubly anchored chromophore-label.COA of Formula: C10H10Cl2N2Pt.

The free-radical 4-amino-2,2,6,6-tetramethylpiperidinyl-1-oxy [14691-88-4] yields cis-Pt(ATMPO)2(NO3)2 [64716-94-5], which is used to label poly(L-glutamate) (I), poly(L-aspartate) (II), and poly(L-lysine) (III). Labeling occurs by displacement of nitrate by polymer side chains. EPR spectra of oriented films of labeled I are strongly anisotropic; several arguments suggest that the major cause is g anisotropy. Spectra of solutions, in several solvents, of labeled I are also anisotropic and monitor the helix-coil transition and polymer aggregation. Since monofunctional, side-chain labels show only isotropic motions, Pt must be bifunctionally anchored to adjacent carboxylates, requiring the label to follow backbone segmental motions. With shorter side chains (II) adjacent double anchoring is impossible; with longer side chains (III), flexibility reduces coupling to backbone motion; in each, therefore, spectra are isotropic. Chromophoric compounds, particularly cis-Pt(bipy)(H2O)2][NO3]2 [64800-95-9], are similarly used. Bifunctional attachment is evidenced by the absence of base-induced UV spectral shifts (characteristic of attachment of OH- to Pt) shown by label alone, and by similarity of the spectra of labeled polymer and labeled oxalate. Induced CD appears for α helix in the region of the chromophore π-π* bands; transition to random coil drastically reduces this CD. With extensively labeled polymer differences in the course of the helix-coil transition as monitored by CD in the backbone region with that monitored in the chromophore region show that the label stabilizes its attached helical residue. A study of Corey-Pauling-Koltun models and extant theories suggests that the induced CD arises by coupling of the carboxylate π-π* and the bound chromophore 1B1 elec. transition moments.

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Howle, Jerry A.; Gale, Glen R.; Smith, Alayne B. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Related Products of 15227-42-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

The antitumor and antimitotic action of the pyridine-tritiated square-planar Pt complex cis-dichloro(dipyridine)platinum(II) (I) [15227-42-6] seems to depend on the dissociation of 1 or both chlorine atoms from the platinum atom. The resulting cationic, aquated species subsequently forms a bond with nucleic acid. I associate avidly with calf thymus DNA, high mol. weight yeast RNA, and bacterial and yeast tRNA, but not with bovine serum albumin, dextran, or purified erythrocyte membranes. Dialysis of the Pt-nucleic acid complexes in distilled water or NaCl results in loss of a portion of the original radioactivity. The Pt-DNA bond is resistant to dissociation by solubilization in alkali followed by trichloroacetic acid (TCA) precipitation Bonding of I to DNA in vitro is inhibited by NaCl; however, prior alkylation of the DNA with nitrogen mustard does not influence its subsequent bonding with I. I associate with intact Ehrlich ascites tumor cells in vitro at 2.deg. and 37.deg. and resists dissociation by washing with saline or TCA as well as solubilization in alkali followed by re-precipitation with TCA.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Trifluoromethanesulfonato-O complexes of platinum(II) and palladium(II), published in 1988, which mentions a compound: 15227-42-6, mainly applied to trifluoromethanesulfonato palladium platinum complex; hydrolysis kinetics trifluoromethanesulfonato platinum, Formula: C10H10Cl2N2Pt.

Reaction of chloroplatinum(II) and chloropalladium(II) complexes containing amine, pyridine, or phosphine ligands at or above room temperature with anhydrous CF3SO3H gave F3CSO3–O complexes, characterized spectroscopically. The complexes cis-[Pt(NH3)2(OSO2CF3)2], trans-[Pt(NH3)2Cl(OSO2CF3)], Pt(en)Cl(OSO2CF3)], [Pt(dppe)(OSO2CF3)2], [Pt(py)2Cl(OSO2CF3)], [Pt(terpy)(OSO2CF3)][CF3SO3], (terpy = 2,2′:6′,2′-terpyridine), trans-[Pd(NH3)2Cl(OSO2CF3)], [Pd(en)(OSO2CF3)2], [Pd(bpy)(OSO2CF3)2] (bpy = 2,2′-bipyridine), and [Pd(PPh3)2(OSO2CF3)2] were isolated. Aquation reactions of selected complexes showed that F3CSO3- hydrolysis is rapid for complexes of both PtII and PdII. Pt(O3SCF3)2 complexes exhibit 2 consecutive rate processes, with k1/k2 ca. 5, consistent with sequential hydrolysis of both anions. Coordinated CF3SO3- in these complexes may be substituted even by neutral coordinating O-donor solvents.

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Recommanded Product: 15227-42-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Thermal decomposition of pyridine complexes of platinum (II). Author is Kukushkin, Yu. N.; Postnikova, E. S..

Thermal anal. of the decomposition of [Pt(py)4]Cl2.3H2O shows that in the initial stage of the reaction there is a joint loss of 2 mols. of pyridine and the H2O of crystallization As a result, trans-[Pt(py)2Cl2] is obtained. The cis-form is somewhat less thermally stable than the trans form. Upon thermal treatment of [Pt(py)4][PtCl4] at 195°, a mixture of geometric isomers of [Pt(py)2Cl2] is obtained.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Dichlorobis(pyridine)platinum(II)(SMILESS: [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2,cas:15227-42-6) is researched.Safety of 1-Bromoundecane. The article 《Multinuclear solid-state NMR of square-planar platinum complexes – Cisplatin and related systems》 in relation to this compound, is published in Canadian Journal of Chemistry. Let’s take a look at the latest research on this compound (cas:15227-42-6).

Multinuclear solid-state NMR (SSNMR) experiments were performed on cisplatin and four related square-planar compounds The wideband uniform rate smooth truncation-Carr-Purcell-Meiboom-Gill (WURST-CPMG) pulse sequence was used in NMR experiments to acquire 195Pt, 14N, and 35Cl ultra-wideline NMR spectra of high quality. Standard Hahn-echo and magic-angle spinning 195Pt NMR experiments are also performed to refine extracted chem. shielding (CS) tensor parameters. Platinum magnetic shielding (MS) tensor orientations are calculated using both plane-wave d. functional theory (DFT) and standard DFT methods. The tensor orientations are highly constrained by mol. symmetry elements, but also influenced to some degree by intermol. interactions. 14N WURST-CPMG experiments were performed on three compounds and elec. field gradient (EFG) parameters (the quadrupolar coupling constant, Cq, and the asymmetry parameter, ηq) are reported. First principles calculations of the 14N EFG tensor parameters and orientations and affirm their dependence on the local hydrogen bonding environment. 35Cl WURST-CPMG experiments on cisplatin and transplatin are reported, using two different static magnetic fields to extract EFG and CS tensor parameters, and 35Cl EFG tensor magnitudes and orientations are predicted using 1st principles calculations Transverse (T2) relaxation data for all nuclei were used to study heteronuclear dipolar relaxation mechanisms, as well as the nature of the local hydrogen bonding environments.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Chemical assembling of silica surface using a reaction of catalytic hydrosilylation, the main research direction is chem assembling silica surface reaction catalytic hydrosilylation.Recommanded Product: cis-Dichlorobis(pyridine)platinum(II).

Chem. assembling of the silica surface modified by dimethylchlorosilane was performed by the catalytic hydrosilylation of 1,3-divinyl-1,1,3,3-tetramethyldisiloxane, α-Me styrene, acetophenone, allyl Bu and allyl glycidyl ethers with dimethylchlorosilane. The effect of the nature of complexes of platinum, palladium, rhodium and ruthenium on the parameters of hydrosilylation was studied. It was shown that the maximum rate of hydrosilylation was observed in the reaction with allyl glycidyl ether, and min., with α-methylstyrene; the most effective catalyst of hydrosilylation was [Rh(CO)2(acac)].

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Recommanded Product: 15227-42-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action. Author is Farrell, Nicholas; Kelland, Lloyd R.; Roberts, John D.; Van Beusichem, Marijo.

The cytotoxicity of transplatinum complexes of structural formula trans-[PtCl2(L)L’)] {L = L’ = pyridine or thiazole, or L = quinoline (R’ = methyl; R” = Me, Ph or CH2phenyl) and L’ = R’R”SO] has been studied in murine L1210 and human tumor cell lines. The results confirm previous observations that use of a sterically hindered planar ligand greatly enhances cytotoxicity, in comparison to trans-[PtCl2(NH3)2], such that in some cases cytotoxicity equivalent to that of the clin. used agent cisplatin [cis-{PtCl2(NH3)2]] is obtained. Results from both the panel of human ovarian carcinoma cell lines and the National Cancer Institute screening panel confirm a different pattern of cytotoxicity, with respect to cisplatin. The new trans-platinum complexes are also non-cross-resistant with cisplatin in both murine and human (human ovarian carcinoma panel) tumor cell lines. Preliminary mechanistic studies using both cis- and trans-[PtCl2(pyridine)2] in L1210 cells have been carried out, to delineate the reasons for both the dramatically enhanced cytotoxicity and the lack of cross-resistance with the clin. used agents. Intracellular uptake is enhanced for pyridine relative to ammine (NH3) complexes. The pyridine complexes also inhibit DNA synthesis, implying a role for DNA binding in their mechanism of action. Binding of the pyridine complexes to calf thymus DNA is, however, significantly less than for the analogous ammine complexes. The presence of trans-pyridine ligands results in steric hindrance, which retards the rate of reaction of trans-[PtCl2(pyridine)2], relative to trans[PtCl2(NH3)2], with other important biomols. such as glutathione. The results point to a potential new class of platinum antitumor complexes acting by a new mechanism and with activity complementary to agents such as cisplatin.

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Hatakeyama, Suekichi; Sato, Choei published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

Assignments are given for the ir spectra of metal-pyridine complexes of the type NiX2.npy, CuX2.2py (X = Cl, Br; n = 1,2,4) and cis-, trans-PtCl2.2py in the 200-1610-cm-1 region. For a series of Ni complexes studied, the ν(Ni-N) vibrations occur at ∼240 cm-1. Cu complexes, on the other hand, show the ν(Cu-N) band near 270 cm-1. Among pyridine vibrations the ν4, ν9, ν10 and ν27, ring deformation vibrations, and the ν16, H in-plane deformation vibration, shift significantly to a higher frequency by complex formation. Among the rest, the ν10, in-plane ring deformation vibration, is the most sensitive upon complex formation.

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Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II). The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Conformational properties of purine and pyrimidine complexes of cis-platinum. Implications for platinum(II)-DNA crosslinking modes. Author is Kistenmacher, Thomas J.; Orbell, John D.; Marzilli, Luigi G..

The stereochem. properties of a variety of cis complexes of Pt(II) containing purine or pyrimidine ligands are examined The critical intramol. conformational parameters [the interbase dihedral angle and the base/coordination plane dihedral angles] are systematically studied and trends sought. Where intramol. interactions are determinative of the adopted mol. conformation, the nature of the steric demands imposed by increasing numbers of exocyclic functional groups contiguous to the Pt binding site are clearly of major importance for the antitumor activity.

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