Category: 15227-42-6

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.COA of Formula: C10H10Cl2N2Pt.Colamarino, Paolo; Orioli, Pier L. published the article 《Crystal and molecular structures of cis- and trans-dichlorobis(pyridine)platinum(II)》 about this compound( cas:15227-42-6 ) in Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999). Keywords: crystal structure platinum complex; pyridine platinum complex structure. Let’s learn more about this compound (cas:15227-42-6).

The crystal and mol. structures of cis- and trans-dichlorobis(pyridine)platinum (I, II resp.) were determined from x-ray diffractometer data by heavy-atom techniques and refined by least squares to R 0.041 and 0.068 for 1000 and 1032 observed intensities for I and II, resp. Crystals of I are monoclinic, space group C2/c, with a 9.408, b 17.110, c 15.270 Å, β 98.53.degree., and Z = 8. Crystals of II are triclinic, space group P1̅, with a 7.695, b 7.091, c 5.542 Å, α 87.6, β 83.7, γ 79.3.degree., and Z = 1. Both complexes consist of discrete mols. with Pt in square planar coordination.

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Tetrahydroisoquinoline – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Article, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, P.H.S., Cancer Research called Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action, Author is Farrell, Nicholas; Kelland, Lloyd R.; Roberts, John D.; Van Beusichem, Marijo, the main research direction is trans platinum antitumor complex resistance structure.HPLC of Formula: 15227-42-6.

The cytotoxicity of transplatinum complexes of structural formula trans-[PtCl2(L)L’)] {L = L’ = pyridine or thiazole, or L = quinoline (R’ = methyl; R” = Me, Ph or CH2phenyl) and L’ = R’R”SO] has been studied in murine L1210 and human tumor cell lines. The results confirm previous observations that use of a sterically hindered planar ligand greatly enhances cytotoxicity, in comparison to trans-[PtCl2(NH3)2], such that in some cases cytotoxicity equivalent to that of the clin. used agent cisplatin [cis-{PtCl2(NH3)2]] is obtained. Results from both the panel of human ovarian carcinoma cell lines and the National Cancer Institute screening panel confirm a different pattern of cytotoxicity, with respect to cisplatin. The new trans-platinum complexes are also non-cross-resistant with cisplatin in both murine and human (human ovarian carcinoma panel) tumor cell lines. Preliminary mechanistic studies using both cis- and trans-[PtCl2(pyridine)2] in L1210 cells have been carried out, to delineate the reasons for both the dramatically enhanced cytotoxicity and the lack of cross-resistance with the clin. used agents. Intracellular uptake is enhanced for pyridine relative to ammine (NH3) complexes. The pyridine complexes also inhibit DNA synthesis, implying a role for DNA binding in their mechanism of action. Binding of the pyridine complexes to calf thymus DNA is, however, significantly less than for the analogous ammine complexes. The presence of trans-pyridine ligands results in steric hindrance, which retards the rate of reaction of trans-[PtCl2(pyridine)2], relative to trans[PtCl2(NH3)2], with other important biomols. such as glutathione. The results point to a potential new class of platinum antitumor complexes acting by a new mechanism and with activity complementary to agents such as cisplatin.

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Tetrahydroisoquinoline – Wikipedia,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Separation of square planar complexes by thin layer chromatography, published in 1966, which mentions a compound: 15227-42-6, mainly applied to PYRIDINE COMPLEX CHROMATOG; THIN LAYER CHROMATOG; CHROMATOG SEPN SQUARE PLANAR COMPLEX; PLATINUM COMPLEX CHROMATOG; PALLADIUM COMPLEX CHROMATOG; SEPN SQUARE PLANAR COMPLEX, Name: cis-Dichlorobis(pyridine)platinum(II).

Uncharged sq. planar Pt and Pd complexes were separated by using plates with a 100 μ coating of silica gel bound by poly(vinyl alc.) and activated for 30 min. at 115°. The solvent was HCCl3 containing 3 drops Me2SO per 100 ml. Typical Rf values are given. Separation of cis- and trans-Ptpy2X2 (X = Cl, Br) was particularly successful, while cis- and trans-Pt(NH3)2Cl2 could not be separated The mechanism of separation appears to be via surface adsorption. Layer thickness, activation conditions, and solvent travel time are therefore very critical

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Oxidation of platinum(II) complexes by antimony pentachloride derivatives, published in 1989, which mentions a compound: 15227-42-6, mainly applied to platinum 2 complex oxidation; antimony chloro derivative oxidation platinum 2; glycine platinum 2 oxidation; pyridine platinum 2 oxidation, Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II).

[Ph3PCH2Ph]2[PtXCl3] (X = Cl, NO2) are oxidized by Sb(BzCl)Cl5 (I) or Et3NCH2Ph[SbCl6] (II) in MeNO2, MeCN or DMF to give (Ph3PCH2Ph)2[PtXCl5]. SbCl5 oxidizes cis- and trans-Pt(py)2Cl2 to give cis- and trans-[Pt(py)2Cl4], resp. I oxidizes trans-[Pt(NH2CH2CO2H)2Cl2] to give trans-[Pt(NH2CH2CO2H)2Cl4] which on reaction with PCl5 in MeCN gives trans-[Pt(NH2CH2COCl)2Cl4]. [Pt(py)4]Cl2 reacted with I to give trans-[Pt(py)2Cl4]. cis- And trans-[PtL2Cl2] (L = PPh3, SMe2) are not oxidized by I or II.

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Tetrahydroisoquinoline – Wikipedia,
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Category: tetrahydroisoquinoline. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about The effects of single administration of an antitumor platinum compound on ornithine decarboxylase activity in certain tissues of mice bearing L1210 leukemia. Author is Morris, Carl R.; Atkins, Loretta M.; Gale, Glen R..

A single dose of cis-dichloro(dipyridine)platinum(II) [15227-42-6], when given to mice bearing 1-day-old L1210 leukemia, suppressed the increase of spleen and liver ornithine decarboxylase (ODC) [9024-60-6] activity which occurs concomitantly with development of the leukemia. The inhibition of ODC, the rate-limiting enzyme in polyamine synthesis, appeared to correlate with the prolonged chemotherapeutic efficacy of a single dose of the platinum complex. These observations suggest an addnl. mechanism by which platinum complexes express their antitumor actions and, in addition, support the view that polyamine synthesis and excretion patterns can be used as predictors of chemotherapeutic response.

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Recommanded Product: cis-Dichlorobis(pyridine)platinum(II). The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about The separation of nonelectrolytic geometric isomers of platinum(II) by thin-layer chromatography. Author is Kauffman, George B.; Benson, Barrett W..

Microscope slides (75 × 25 mm.) were cleaned with detergent, rinsed in H2O, and coated with a slurry containing 1 part Silica Gel G in 3 parts of a 1:1 volume mixture of MeOH and redistilled CH2Cl2. The plates were air dried for 10-20 min. and activated for 1 hr. at 110°. Saturated solutions of the cis isomers, trans isomers, and a 1:1 by weight mixture of both Pt isomers in CH2Cl2 were applied to the plate. The plate was air dried for 2-3 min. and then developed with an ascending technique until the solvent had attained ∼6 cm. The plate was then air dried and the intense yellow-spots detected in a screw-cap jar containing I. The difference of the cis and trans migrations. ΔRf, indicated the effectiveness of separation For [Pt(Et2S)2Cl2] developed in C6H6, CH2Cl2, and 19:1 mixture of C6H6:Me2CO, ΔRf was 0.45, 0.45, and 0.45, resp. For [Pt(Bu3P)2Cl2] developed in C6H6, CH2Cl2, and a 1:1 mixture of C6H6:CH2Cl2 ΔRf was 0.95, 0.55 and 0.80, resp. For [Pt(pyridine)2Cl2] developed in CH2Cl2, 5:1 of C6H6:Me2CO Me2CO, and 5:1 of CH2Cl2:Me2CO ΔRf was 0.20, 0.45, and 0.35 resp. For [(Pr3P)2Pt2(PhS)2Cl2] developed in C6H6 and CH2Cl2 ΔRf was 0.40 and 0.45, resp. For [(Pr3P)2Pt(EtS)2Cl2] developed in CH2Cl2, 1:2 of C6H6:CH2Cl2, and C6H6 ΔRf was 0.40, 0.40, and 0.30, resp. For [Pr3P)2Pt2(p-O2NC6H4S)2Cl2] developed in CH2Cl2 and 2:1 of C6H6:Me2CO ΔRf was 0.30, 0.20, and 0.10, resp. Two (200 × 100 mm.) silica gel plates were prepared A mixture of 100 mg. cis and 100 mg. trans [Cl2Pt(PBu3)2] in CH2Cl2 were applied to the plates and developed with C6H6. The bands at Rf 0.0-0.1 and 0.85-0.10 were removed and eluted with Me2CO and CH2Cl2, resp. Evaporation yielded 91% cis isomer and 93% trans isomer. Thus, complete separation had been achieved with solvent induced isomerization.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Mattern, I. E.; Cocchiarella, L.; Van Kralingen, C. G.; Lohman, P. H. M. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Reference of cis-Dichlorobis(pyridine)platinum(II). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

Eleven Pt compounds with N donor ligands (aminocyclopentane, aminocyclohexane, pyridine, etc.), previously tested for antitumor activity, were studied for induction of prophage λ and for mutagenicity in the Ames assay, with various strains of Salmonella. The compounds included cis and trans isomers of Pt(II) and Pt(IV) complexes and were tested with and without metabolic activation. All the cis compounds elicited prophage induction, whereas the trans compounds were inactive. Mutagenicity was found only in strains containing the R factor, indicating that SOS-type repair processes are required for the conversion of initial DNA lesions into mutations. Mutation induction was also influenced by the excision-repair process. The 2 trans compounds were not, or only slightly, mutagenic; all other compounds were mutagenic in at least one strain, exhibited a 2-20-fold increase over the spontaneous background level. Addition of liver homogenate had no significant effect on the number of mutants. One compound induced exclusively frameshift mutations. The other mutagenic compounds induced frameshift mutations as well as base-pair substitutions. Seven compounds were more mutagenic for the repair-proficient than for the repair-deficient strains; only one showed the opposite effect. Apparently, for mutagenicity testing of Pt compounds, repair-proficient strains are more sensitive indicators. The differences in response of the various strains toward the compounds suggest the formation of different DNA lesions and(or) a selective action of repair processes on these lesions. In general, a good qual. correlation was observed between prophage-inducing capacity, mutagenicity in bacterial and mammalian cells and antitumor activity.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Recommanded Product: cis-Dichlorobis(pyridine)platinum(II).Colangelo, Donato; Ghiglia, AnnaLisa; Viano, Ilario; Mahboobi, Homa; Ghezzi, AnnaRita; Cassino, Claudio; Osella, Domenico published the article 《Might telomerase enzyme be a possible target for trans-Pt(II) complexes?》 about this compound( cas:15227-42-6 ) in Journal of Inorganic Biochemistry. Keywords: trans platinum antitumor complex telomerase target. Let’s learn more about this compound (cas:15227-42-6).

Telomerase is a ribonucleoprotein polymerase that synthesizes telomeric DNA (TTAGGG) repeats. Previously, we have studied the effect on telomerase enzyme of several cis-platinum(II) complexes bearing aromatic amines as bulky carrier groups. All these complexes possess cis-geometry, according to the Cleare and Hoschele’s rule. Since recent reports have dealt with the anti-cancer activity of trans-platinum compounds, in this study we have investigated the Farrell’s prototypical trans-[Pt(Cl)2(pyridine)2], hereafter called trans-PtPy, to understand whether it may possess any anti-telomerase activity. The trans-PtPy has low water solubility and requires DMSO as co-solvent, thus making the biol. tests problematic. The effect of trans-PtPy on MCF-7 cell line concerning log-term telomerase inhibition, telomerase-related gene expression, viability, and apoptosis was evaluated. In a cell-free biochem. assay, trans-PtPy showed significant and dose-dependent inhibition of semi-purified telomerase. The bulk of data indicate that trans-PtPy acts as a non-properly selective anti-proliferative agent, although it shows an initial telomerase inhibitory effect. Telomere length reduction seems not to be the main mechanism causing the observed cell apoptosis. For comparison purpose, results on cis-[Pt(Cl)2(pyridine)2] are reported.

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Recommanded Product: 15227-42-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Bis(pentafluorophenyl) complexes of palladium(II) and of platinum(II). Author is Uson, R.; Fornies, J.; Gimeno, J.; Espinet, P.; Navarro, R..

The preparation of 8 bis(pentafluorophenyl) complexes of Pd(II) and of Pt(II) with monodentate and bidentate N-donor ligands is described together with a preparation of a Pd(II) complex of 1,2-bis(diphenylphosphino)ethane. Assignments of cis or trans configuration are discussed which depend upon the splitting or disappearance of certain bands in ir.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Mass spectrometry of platinum(II) complexes. Comparison of cis and trans isomers. Fragmentation and rearrangement pathways, published in 1971, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Safety of cis-Dichlorobis(pyridine)platinum(II).

The mass spectra of 8 pairs of cis and trans isomers of PtL2X2 (L=NH3, pyridine PEt3, or PPh3; X=Cl, Br, or I) are presented and discussed. Two chelates, Pt(bipy)Cl2 and Pt(dpm)Cl2(dpm=di-α-pyridylmethane), are also included. The most significant results are: (1) parent ions can be observed for almost all these relatively involatile coordination compounds; (2) most ligand fragmentations and rearrangements occur with ligand-metal bonds intact; (3) some rearrangements appear to involve the metal; (4) cis and trans isomers of phosphine complexes give different fragmentation patterns; (5) spectra of chelates differ considerably from the spectra of analogous nonchelates; (6) in Pt(NH3)2Cl2 and Pt(py)2Cl2, little or no difference is observed in the spectra of cis and trans isomers after electron impact. Therefore, excitation to a tetrahedral state may take place.

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