Category: 15227-42-6

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Dichlorobis(pyridine)platinum(II)(SMILESS: [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2,cas:15227-42-6) is researched.Related Products of 51856-79-2. The article 《Quantitative measurement of the reduction of platinum(iv) complexes using X-ray absorption near-edge spectroscopy (XANES)》 in relation to this compound, is published in Metallomics. Let’s take a look at the latest research on this compound (cas:15227-42-6).

The platinum(ii) drugs cisplatin, carboplatin and oxaliplatin are usefully employed against a range of malignancies, but toxicities and resistance have spurred the search for improved analogs. This has included investigation of the platinum(iv) oxidation state, which provides greater kinetic inertness. It is generally accepted that Pt(iv) complexes must be reduced to Pt(ii) for activation. As such, the ability to monitor reduction of Pt(iv) complexes is critical to guiding the design of candidates, and providing mechanistic understanding. Here we report in full that the white line height of X-ray absorption near-edge spectra (XANES) of Pt complexes, normalized to the post-edge min., can be used to quant. determine the proportion of each oxidation state in a mixture A series of Pt(iv) complexes based on the Pt(ii) complexes cisplatin and transplatin were prepared with chlorido, acetato or hydroxido axial ligands, and studies into their reduction potential and cytotoxicity against A2780 human ovarian cancer cells were performed, demonstrating the relationship between reduction potential and cytotoxicity. Anal. of white line height demonstrated a clear and consistent difference between Pt(ii) (1.52 ± 0.05) and Pt(iv) (2.43 ± 0.19) complexes. Reduction of Pt(iv) complexes over time in cell growth media and A2780 cells was observed by XANES, and shown to correspond with their reduction potentials and cytotoxicities. We propose that this method is useful for monitoring reduction of metal-based drug candidates in complex biol. systems.

There is still a lot of research devoted to this compound(SMILES：[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2)Product Details of 15227-42-6, and with the development of science, more effects of this compound(15227-42-6) can be discovered.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Category: tetrahydroisoquinoline. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Interaction of pyridineplatinum(II) complexes with alkyl sulfoxides. Author is de Vekki, D. A..

The reaction of cis- and trans-[Pt(py)2Cl2] and [Pt(py)4]Cl2 with DMSO and Et2SO was studied by NMR. The products of the reaction are pyridine sulfoxide complexes and bis(sulfoxide) complexes. With heating cis/trans isomerization occurred, determining the configuration of the final products.

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Tetrahydroisoquinoline – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Platinum Metals Review called Antitumor platinum compounds. Relation between structure and activity, Author is Cleare, Michael J.; Hoeschele, J. D., which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Reference of cis-Dichlorobis(pyridine)platinum(II).

A pair of cis leaving groups is necessary but not sufficient for anticancer activity in Pt(II) complexes. The complex should be neutral and the lability of the leaving groups should be about that of Cl in cis-dichlorodiammineplatinum(II) [15663-27-1]. The other ligands should be relatively inert and neutral. Amines are preferred, although varying their structure has not given a clear pattern. However the activity of compounds containing alicyclic amines indicates that some Pt compounds may be highly selective.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Palladium(II) and platinum(II) saccharinate complexes containing pyridine and 3-acetylpyridine: Synthesis, crystal structures, fluorescence and thermal properties.Related Products of 15227-42-6.

New Pd(II) and Pt(II) complexes of saccharinate (sac), trans-[Pd(py)2(sac)2] (1), cis-[Pt(py)2(sac)2] (2), trans-[Pd(3-acpy)2(sac)2] (3) and cis-[Pt(3-acpy)2(sac)2] (4) (py = pyridine and 3-acpy = 3-acetylpyridine) were synthesized. Elemental anal., UV-visible, IR, NMR and TG/DTA characterizations were carried out. The structures of 1-4 were determined by x-ray diffraction. The Pd(II) and Pt(II) ions are coordinated by two N-bonded sac ligands, and two N atoms of py or 3-acpy, forming a distorted square-planar geometry. The Pd(II) complexes (1 and 3) are trans isomers, while the Pt(II) complexes (2 and 4) are cis isomers. The mononuclear species in the solid state are connected by weak intermol. C-H···O H bonds, C-H···π and π···π stacking interactions. The Pt(II) complexes show significant fluorescence at room temperature

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Tetrahydroisoquinoline – Wikipedia,
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Safety of cis-Dichlorobis(pyridine)platinum(II). The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Rotation and conformation of purine ligands in cis-bis(6-oxopurine)platinum compounds. Author is Marcelis, A. T. M.; Van der Veer, J. L.; Zwetsloot, J. C. M.; Reedijk, J..

cis-[PtL2L12]2+ (L = guanosine, 9-methylhypoxanthine, L1 = Me-substituted 1,3-propanediamines, py, α-picoline, 2,2′-bipyridine, 1,2-bis(pyridin-2-yl)ethane) were prepared and studied by NMR. Rotation of L about their Pt-N7 bonds is fast on the NMR time scale, when no Me groups are present on the nitrogens of the 1,3-propanediamine ligands. Rotation is slow when 2 Me groups are present on 1 N of a 1,3-propanediamine chelate. A single Me group on a N hardly seems to interfere with this rotation. Coordinated pyridines do not hinder rotation. In compounds containing 2-methylpyridine ligands, the rotation of the pyridines is slow at room temperature, but becomes fast at higher temperatures Rotation of L, however, is fast on the NMR time scale from -30 to +90°. In compounds containing 1,2-bis(pyridin-2-yl)ethane, rotation of L is slow at low temperatures, but becomes fast at room temperature Furthermore, the results obtained with these compounds show that the purines are preferentially oriented in a head-to-tail arrangement.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis, characterization and cytotoxicity of some palladium(II), platinum(II), rhodium(I) and iridium(I) complexes of ferrocenylpyridine and related ligands. Crystal and molecular structure of trans-dichlorobis(3-ferrocenylpyridine)palladium(II), published in 2004-05-01, which mentions a compound: 15227-42-6, mainly applied to ferrocenyl pyridine preparation redox potential reaction Group VIII complex; palladium ferrocenylpyridine complex preparation structure cyclic voltammetry human cytotoxicity; platinum pyridinylferrocene chloro complex preparation human cytotoxicity; iridium rhodium pyridylferrocene complex human cytotoxicity structure activity relationship; crystal structure palladium ferrocenylpyridine chloro complex; mol structure palladium ferrocenylpyridine chloro complex, Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II).

The preparation of a series of ferrocenyl nitrogen donor ligands including ferrocenylpyridines, ferrocenylphenylpyridines and 1,1′-di(2-pyridyl)ferrocene is described. Coordination studies of the substituted pyridines (L) were carried out with platinum, palladium, rhodium and iridium. This resulted in the preparation of the following types of complexes: [MCl(CO)2(L)] and [M(cod)(L)2]ClO4 where M = Rh or Ir, cod = 1,5-cyclooctadiene; [M’Cl2(L)2] where M’ = Pt or Pd. The X-ray crystal structure of trans-dichlorobis(3-ferrocenylpyridine)palladium was obtained. The complexes were screened for activity against two human cancer cell lines. At least two of the complexes displayed growth inhibition similar to that of the widely used chemotherapeutic agent, cisplatin.

From this literature《Synthesis, characterization and cytotoxicity of some palladium(II), platinum(II), rhodium(I) and iridium(I) complexes of ferrocenylpyridine and related ligands. Crystal and molecular structure of trans-dichlorobis(3-ferrocenylpyridine)palladium(II)》,we know some information about this compound(15227-42-6)Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II), but this is not all information, there are many literatures related to this compound(15227-42-6).

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Tetrahydroisoquinoline – Wikipedia,
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SDS of cas: 15227-42-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Solid-phase thermal transformations of platinum(IV) aminate complexes. Author is Kukushkin, Yu. N.; Sedova, G. N.; Belyaev, A. N.; Konovalov, L. V..

The thermal behavior of onium chloroplatinates of the type (AH)2[PtCl6] (A = NH3, MeNH2, 0.5 en, piperidine, py, γ-picoline, NH2Ph, p-toluidine, quinoline, 0.5 2,2′-bipyridine) was studied by derivatog. and IR spectral anal. The heating of solid (AH)2[PtCl6] led to the formation of trans-PtL2Cl4 (L = py, γ-picoline) and cis-PtQ2Cl4 (Q = p-toluidine) and subsequently to the formation of cis-PtA2Cl2. When (AH)2[PtCl6] (A = piperidine) was heated (AH)2[PtCl4] was formed. These results were compared with those for the corresponding palladates.

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Tetrahydroisoquinoline – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Application of 15227-42-6.Stetsenko, A. I.; Dmitrieva, E. S.; Yakovlev, K. I. published the article 《The investigation of platinum(II) complexes with adenine, adenosine and 2-aminopyrimidines》 about this compound( cas:15227-42-6 ) in Journal of Clinical Hematology and Oncology. Keywords: platinum adenine adenosine aminopyrimidine; adenine platinum complex; adenosine platinum complex; aminopyrimidine platinum complex; pyrimidine amino platinum complex; ammine platinum complex; pyridine platinum complex; ethylenediamine platinum complex. Let’s learn more about this compound (cas:15227-42-6).

[Pt2(NH3)4Cl2L]Cl2 (L = adenine, adenosine) were prepared by the addition of ligand to cis-[Pt(NH3)2Cl2] solution [Pt(NH3)2L](NO3)2 were obtained by adding L to cis-[Pt(NH3)2(H2O)2](NO3)2 solution 2-Aminopyrimidine (L1) and 2-amino-4-phenylpyrimidine (L2) reacted with aqueous K2[PtCl4] to yield trans-[PtL12Cl2] and trans-[PtL22Cl2], resp. The cis-[PtA2L12]Cl2 (A = NH3, pyridine, 0.5 ethylenediamine) were obtained by the substitution reaction of cis-[PtA2Cl2] with 2-aminopyrimidine. The cis-[PtA2(H2O)2](NO3)2 reacted with 2-aminopyrimidine to afford cis-[PtA2L12](NO3)2 and cis-[PtA2L1](NO3)2 (A = NH3, 0.5 ethylenediamine), depending on the stoichiometric ratios of the reactants.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Multistate luminescence, absorption and MCD studies of the relative energies of d → d, d → π*, and n,π → π* transitions for the cis and trans isomers of dichlorobis(pyridine)platinum(II), published in 1983-02-16, which mentions a compound: 15227-42-6, mainly applied to UV luminescence platinum chloride pyridine; magnetic CD platinum chloride pyridine, Computed Properties of C10H10Cl2N2Pt.

Luminescence, absorption, and magnetic CD (MCD) experiments are reported for cis- and trans-dichlorobis(pyridine)platinum(II). For the trans isomer, an anal. of the temperature dependence of the lifetimes and luminescence intensities indicates that emission at 605 nm is from 2 excited π* states separated by 240 cm-1. For the cis isomer, time-resolved spectroscopy allowed observation of 2 emission bands at 600 and 700 nm, which were assigned from their lifetimes to π* → d and d → d transitions, resp. Further, temperature dependent lifetime studies show that the 600-nm band (π* → d) is from 2 electronic states separated by 200 cm-1. The absorption spectra of both isomers were measured at room and low temperatures in solution, in glasses, and in KCl pellets. From a comparison with the pyridine and Pt(NH3)2Cl2 absorption and MCD spectra and MO calculations, the observed absorption bands for Pt(py)2Cl2 are assigned as d → d, d → π*, and n, π → π* transitions. For the cis isomer the lowest unoccupied mol. orbital is a d metal orbital.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

HPLC of Formula: 15227-42-6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Spectral studies of some pyridine and bipyridine complexes of platinum(II). Author is Agarwala, Badri Vishal.

Electronic absorption spectra and magnetic CD (MCD) spectra were studied for the square planar complexes cis- and trans-Pt(py)2Cl2 and Pt(2,2′-bipyridine)Cl2(I). Detailed studies were carried out for I due to its fair solubility in many solvents and the solvent effect on its electronic spectra was investigated. The band assignments of the electronic spectra are discussed and are supported by the MCD spectra. NMR and magnetic studies were also carried out on the complexes to further elucidate their configuration. All the complexes studied are diamagnetic in conformity with their square planar arrangement.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem