Category: 15227-42-6

Stetsenko, A. I.; Dmitrieva, E. S.; Yakovlev, K. I. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Application of 15227-42-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

[Pt2(NH3)4Cl2L]Cl2 (L = adenine, adenosine) were prepared by the addition of ligand to cis-[Pt(NH3)2Cl2] solution [Pt(NH3)2L](NO3)2 were obtained by adding L to cis-[Pt(NH3)2(H2O)2](NO3)2 solution 2-Aminopyrimidine (L1) and 2-amino-4-phenylpyrimidine (L2) reacted with aqueous K2[PtCl4] to yield trans-[PtL12Cl2] and trans-[PtL22Cl2], resp. The cis-[PtA2L12]Cl2 (A = NH3, pyridine, 0.5 ethylenediamine) were obtained by the substitution reaction of cis-[PtA2Cl2] with 2-aminopyrimidine. The cis-[PtA2(H2O)2](NO3)2 reacted with 2-aminopyrimidine to afford cis-[PtA2L12](NO3)2 and cis-[PtA2L1](NO3)2 (A = NH3, 0.5 ethylenediamine), depending on the stoichiometric ratios of the reactants.

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Tetrahydroisoquinoline – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Spectra and structure of pyridine coordination compounds》. Authors are Herbelin, F.; Herbelin, J. D.; Mathieu, J. P.; Poulet, H..The article about the compound:cis-Dichlorobis(pyridine)platinum(II)cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2).Quality Control of cis-Dichlorobis(pyridine)platinum(II). Through the article, more information about this compound (cas:15227-42-6) is conveyed.

Ir absorption spectra of 15 coordination compounds of pyridine with Pt, Rh, and Ir have been observed, 100-3200 cm.-1; in some cases uv and Raman spectra have also been observed. The effect of coordination on the vibration spectrum of pyridine, the structure of the coordinated units, and the differences in the spectra of cis-trans isomers are discussed.

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Tetrahydroisoquinoline – Wikipedia,
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Berezin, V. I.; Ganin, V. V.; Kovrikov, A. B.; Lipnitskii, I. V.; Rogalevich, N. L. published the article 《Spectral and structural properties of the crystalline complex dichlorodi(pyridine)palladium》. Keywords: IR Raman palladium pyridine chloride.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).COA of Formula: C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

An IR and Raman spectroscopic investigation of crystalline PdPy2Cl2 was made. The vibrational frequencies were measured in the region from 3500 to 30 cm-1. The assignments of the observed bands were made on the basis of the frequency calculation for trans- and cis-PdPy2Cl2 plane and nonplanar configurations, using force constants, modelled from constants of [Pd(NH3)4]2+ and [PdCl4]2-. The calculation results were used to specify the metal-ligands stretching constants and their interactions.

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Tetrahydroisoquinoline – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Ligand effects in platinum binding to DNA. A comparison of DNA binding properties for cis- and trans-[PtCl2(amine)2] (amine = NH3, pyridine), the main research direction is DNA binding platinum pyridine complex.Electric Literature of C10H10Cl2N2Pt.

The DNA binding properties of cis- and trans-[PtCl2(pyridine)2] have been examined and compared with their NH3 analogs, cis- and trans-DDP. The presence of a planar ligand reduces the rates of DNA binding but does not greatly affect the overall conformation of CT DNA, as measured by CD spectroscopy. The sequence specificity of trans-[PtCl2(py)2] includes alternating purine-pyrimidine sequences. The sequence specificity is further different between the two pyridine isomers, and the steric effects of two cis-pyridine groups are demonstrated by the appearance of relatively few binding sites in the 49-bp duplex. The effects of the pyridine ligand are further manifested by a greatly enhanced DNA-DNA interstrand crosslinking efficiency for the trans isomer, with a cross-link per adduct frequency of between 0.14 and 0.23, depending on the rb of the sample. The unwinding of closed circular pUC19 DNA by trans-[PtCl2(pyridine)2] is also more efficient than that by either DDP isomer. In contrast, little unwinding is induced by cis-[PtCl2(pyridine)2]. These results invert the standard cis/trans structure-activity relationships observed previously for [PtCl2(NH3)2]. The results are discussed with respect to the previously demonstrated effect of activation of the trans-platinum geometry using sterically hindered ligands.

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Tetrahydroisoquinoline – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Electrochemical reduction of geometric isomers of [Pt(C5H5N)2Cl2Br2] on a dropping mercury electrode in propylene carbonate solutions, the main research direction is electrochem reduction geometric isomer platinum complex; redox reaction coordinated pyridine platinum complex; pyridine halo platinum complex electroreduction; bromo chloro pyridine platinum complex electroreduction.Quality Control of cis-Dichlorobis(pyridine)platinum(II).

The method of classical polarog. on a dropping Hg electrode in propylene carbonate was used to study the reduction of the isomeric complexes of Pt(IV) of type [Pt(C5H5N)2Cl2Br2] and of Pt(II) of type [Pt(C5H5N)2X2], where X = Cl, Br. The reduction of cis,cis,trans-[Pt(C5H5N)2Cl2Br2] and of cis,trans,cis-[Pt(C5H5N)2Cl2Br2] occurs according to an electrochem.-chem. mechanism during which, and following the 1-electron reduction of Pt(IV) to Pt(III), there occurs an intramol. redox process with participation of coordinated pyridine.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Mechanism of cis-trans photoisomerization of dichlorodipyridineplatinum,(II), published in 1971, which mentions a compound: 15227-42-6, mainly applied to dichlorodipyridineplatinum photoisomerization; complex dichlorodipyridineplatinum photoisomerization; platinum dichlorodipyridine photoisomerization, Product Details of 15227-42-6.

The photochem. behavior of cis- and trans-Pt(py)2Cl2 in CHCl3 solutions has been investigated using 313 nm light. The cis isomer undergoes 2 simultaneous photoreactions, one being an intramol. photoisomerization process (Φisom ∼0.04) and the other a photodissociation reaction involving the pyridine ligand (Φdiss ∼ 0.025). This latter photoreaction provides an intermol. path for the cis → trans isomerization since its products (namely, free pyridine and Pt-containing species) recombine thermally to give cis- and trans-Pt(py)2Cl2 in a 2:1 ratio. The trans isomer undergoes photoisomerization and pyridine release but with much lower quantum yields (∼0.001). Qual. results concerning the photochem. behavior of the above complexes in MeOH solutions upon 254 or 313 nm irradiation are also reported.

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Tetrahydroisoquinoline – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Thermal isomerization of complex platinum(II) compounds, published in 1972, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Computed Properties of C10H10Cl2N2Pt.

The thermal cis-trans isomerization of [PtA2I2] complexes, where A = NH3, MeNH2, EtNH2, pyridine, was studied by derivatography. The heat of isomerization is 1-7 kcal/mole. trans-[Pt(R2SO)ACl2]-type complexes melt upon heating and isomerize in the melt. The isomerization reaction proceeds through formation of a tetrahedral intermediate.

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Tetrahydroisoquinoline – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Platinum compounds with anti-tumor activity, the main research direction is platinum compound tumor structure; platinum compound antitumor structure.Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II).

Ten Pt coordination complexes with different ligands, comprising both Pt(II) and Pt(IV) complexes of which the cis-compounds all possessed at least some antitumor activity and the trans-compounds were inactive, were tested as to their effect on cell survival and the induction and repair of DNA damage in cultured Chinese hamster cells (CHO). The Pt-compounds were divided in 3 groups on the basis of their cytotoxicity. The compounds with high cytotoxicity were also active antitumor drugs, but a clear correlation between cytotoxicity and antitumor activity was not observed All compounds inhibited semi-conservative DNA synthesis and induced DNA repair replication. No induction of DNA single strand breaks and DNA cross-links was detected. However, the occurrence of alkali labile sites in the DNA of treated CHO cells demonstrated the induction of unidentified DNA bases damages. The cis-compounds were more mutagenic than the trans-compounds

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Tetrahydroisoquinoline – Wikipedia,
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Formula: C10H10Cl2N2Pt. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Multinuclear solid-state NMR of square-planar platinum complexes – Cisplatin and related systems. Author is Lucier, Bryan E. G.; Reidel, Alex R.; Schurko, Robert W..

Multinuclear solid-state NMR (SSNMR) experiments were performed on cisplatin and four related square-planar compounds The wideband uniform rate smooth truncation-Carr-Purcell-Meiboom-Gill (WURST-CPMG) pulse sequence was used in NMR experiments to acquire 195Pt, 14N, and 35Cl ultra-wideline NMR spectra of high quality. Standard Hahn-echo and magic-angle spinning 195Pt NMR experiments are also performed to refine extracted chem. shielding (CS) tensor parameters. Platinum magnetic shielding (MS) tensor orientations are calculated using both plane-wave d. functional theory (DFT) and standard DFT methods. The tensor orientations are highly constrained by mol. symmetry elements, but also influenced to some degree by intermol. interactions. 14N WURST-CPMG experiments were performed on three compounds and elec. field gradient (EFG) parameters (the quadrupolar coupling constant, Cq, and the asymmetry parameter, ηq) are reported. First principles calculations of the 14N EFG tensor parameters and orientations and affirm their dependence on the local hydrogen bonding environment. 35Cl WURST-CPMG experiments on cisplatin and transplatin are reported, using two different static magnetic fields to extract EFG and CS tensor parameters, and 35Cl EFG tensor magnitudes and orientations are predicted using 1st principles calculations Transverse (T2) relaxation data for all nuclei were used to study heteronuclear dipolar relaxation mechanisms, as well as the nature of the local hydrogen bonding environments.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of the American Chemical Society called Stereospecific synthesis of cyclobutanol derivatives using a 5 minus 1 methodology and platinum(II), Author is Stewart, Frederick F.; Jennings, P. W., which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, SDS of cas: 15227-42-6.

Cycloaddition reaction of the carbene N2CHCO2Et to norbornene in the presence of Rh(II) gave 95% tricyclic esters I (R = CO2Et), which were reduced with LiAlH4 to give 63% I (R = CH2OH) (II). Kinetic resolution of II by oxidative insertion with Pt(py)2Cl2 gave 93% complex III (R = CH2OH) and its isomer, which underwent stereospecific acid-catalyzed ring expansion to give 70-80% complexes IV (R1 = H, Me, CHO; L = py) and their isomers. Ligand substitution with P(OMe)3 gave 100% IV [L = P(OMe)3], which underwent reductive elimination on heating to give 80-90% III (R = OR1).

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem