Category: 15227-42-6

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Spectroscopy Letters called Spectral studies of some pyridine and bipyridine complexes of platinum(II), Author is Agarwala, Badri Vishal, the main research direction is platinum pyridine bipyridine spectra; UV platinum pyridine bipyridine; magnetic CD platinum pyridine bipyridine.Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II).

Electronic absorption spectra and magnetic CD (MCD) spectra were studied for the square planar complexes cis- and trans-Pt(py)2Cl2 and Pt(2,2′-bipyridine)Cl2(I). Detailed studies were carried out for I due to its fair solubility in many solvents and the solvent effect on its electronic spectra was investigated. The band assignments of the electronic spectra are discussed and are supported by the MCD spectra. NMR and magnetic studies were also carried out on the complexes to further elucidate their configuration. All the complexes studied are diamagnetic in conformity with their square planar arrangement.

Although many compounds look similar to this compound(15227-42-6)Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II), numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Radiosensitization of EMT6 cells by four platinum complexes, the main research direction is radiosensitization EMT cell platinum complex; oxygen radiosensitization platinum complex.Category: tetrahydroisoquinoline.

The radiosensitization of oxygenated and hypoxic exponentially growing EMT6 cells in vitro was measured. The dose modifying factors obtained with 200 and 400 μM trans-bis(2-nitroimidazole)dichloroplatinum II (NIPt) in hypoxic cells were 1.5 and 2.1, resp. For trans-bis(2-amino-5-nitrothiazole)dichloroplatinum II (Plant) under the same conditions, the dose modifying factor was 1.5 at 200 μM and 1.8 at 400 μM. Neither compound sensitized oxygenated cells when tested under similar protocols. Unlike the trans complexes, (1,2-diamino-4-nitrobenzene)dichloroplatinum II (Plato) was cytotoxic toward the hypoxic cells in the absence of x-rays. The time course of cytotoxicity for 100 μM Plato in exponentially growing cells showed rapid killing of hypoxic cells, and much less toxicity toward oxygenated cells. In radiosensitization studies, dose modifying factors of 1.6 and 2.0 were found with 200 and 400 μM Plato, resp., in hypoxic cells. The compound did not sensitize aerobic cells. The well known Pt complex cis-dipyridinedichloroplatinum II (PyPt) represents a cis-Pt heterocyclic aromatic complex that does not have a nitro-functionality. The dose modifying factor obtained with 400 μM PyPt in hypoxic cells was 1.7. On a molar basis, the nitro-functional Pt complexes appear to be more effective as hypoxic cell radiosensitizers than the corresponding free ligands.

Although many compounds look similar to this compound(15227-42-6)Category: tetrahydroisoquinoline, numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Peloso, Arnaldo researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Reference of cis-Dichlorobis(pyridine)platinum(II).They published the article 《Kinetics of oxidation of dichlorobis(substituted pyridine)platinum(II) and of reduction of tetrachlorobis(substituted pyridine)platinum(IV) complexes》 about this compound( cas:15227-42-6 ) in Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999). Keywords: chloropyridineplatinum complex oxidation reduction kinetics; pyridinechloroplatinum complex oxidation reduction kinetics; platinum pyridine complex oxidation reduction. We’ll tell you more about this compound (cas:15227-42-6).

The kinetics of oxidation of cis-[PtCl2L2] (L = py, 3-methyl-, 3- and 4-chloro-, 3- and 4-cyanopyridine) by [AuCl4]- in the presence of [NEt4]Cl and of reduction of cis-[PtCl4L2] by [NEt4]I were studied in MeCN. The rate law for the oxidation reaction was rate = k3[PtCl2L2][AuCl4-][Cl-], where k3 was unaffected by changes in L and had a value ∼100 times higher than that previously found for related phenanthrolineplatinum(II) complexes. The rate law for the reduction reaction was rate = k2[PtCl4L2][I-], where k2 was influenced by the basicity of L, as in related phenanthrolineplatinum(IV) complexes. The kinetic results were discussed in terms of σ and π interactions between the Pt and L.

Although many compounds look similar to this compound(15227-42-6)Reference of cis-Dichlorobis(pyridine)platinum(II), numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Multinuclear NMR study and crystal structures of complexes of the types cis- and trans-Pt(Ypy)2X2, where Ypy = pyridine derivative and X = Cl and I, the main research direction is crystal structure platinum picoline pyridine halo; platinum pyridine picoline lutidine halo preparation structure; isomerization cis trans platinum pyridine halo; NMR platinum 195 pyridine halo complex; trans effect platinum pyridine halo complex.Application of 15227-42-6.

Cis- and trans-Pt(Ypy)2X2, where Ypy is a Me derivative of pyridine and X = Cl or I, were studied by spectroscopic methods, especially by multinuclear NMR spectroscopy. In 195Pt NMR, the cis-dichloro compounds were observed between -1998 and -2021 ppm in CDCl3, while the trans compounds were found at slightly lower field, between -1948 and -1973 ppm. The diiodo species were observed at much higher field, between -3199 and -3288 ppm for the cis isomers and between -3122 and -3264 ppm for the trans isomers. In 1H NMR, the 3J(195Pt-1H) coupling constants are larger for the cis compounds (∼42 ppm) than for the trans isomers (∼33 ppm). In 13C NMR, the values of 3J(195Pt-13C) also are larger for the cis complexes. There seems to be a slight dependence of the pKa values of the protonated ligands on the δ(Pt) chem. shifts. The presence of π-bonding between Pt and the pyridine ligands do not seem very important. The crystal structures of three dichloro and five diiodo complexes were determined, in an attempt to obtain information on the trans influence of the three ligands. The iodo ligand has the greatest trans influence. Chloro and pyridine ligands seem to have similar trans influence, although, the chloro ligand seems to have a slightly larger influence than pyridine derivatives One structure, trans-Pt(2-pic)2I2, showed a syn conformation of the two 2-picoline ligands.

Although many compounds look similar to this compound(15227-42-6)Application of 15227-42-6, numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kharitonov, Yu. Ya.; Evstaf’eva, O. N.; Baranovskii, I. B.; Mazo, G. Ya. researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Formula: C10H10Cl2N2Pt.They published the article 《Infrared spectroscopic study of dicyanato complexes of platinum》 about this compound( cas:15227-42-6 ) in Zhurnal Neorganicheskoi Khimii. Keywords: IR cyanide Pt complex; cyanide Pt complex IR; platinum cyanide complex IR. We’ll tell you more about this compound (cas:15227-42-6).

trans-[Pt(NH3)2(CN)2] (I), trans-[Pt(ND3)2(CN)2], trans-Pt(NH3)2(CN)2.AgNO3, trans-[Pt(NH3)2(CN)2X2] (II) where X = Cl, Br, I, or OH, trans-[Pt(ND3)2(CN)2X2] where X = Br or I, cis-[PtA(CN)2] where A = (NH3)2, (pyridine)2, ethylenediamine, or (thiourea)2, cis-[Pten(CN)2X2] where X is Br or OH were studied by ir spectroscopy. Maximum of these compounds are tabulated. On oxidation of Pt, the νpt-CN did not change while νC-N increased ∼40-70 cm.-1 All trans complexes had a singlet and all cis had a doublet νCN. The split for cis complexes was larger for Pt(II) than for Pt(IV). The force constant of the C-N bond changed insignificantly, especially in Pt(II) complexes, on transition from ionic to covalent cyanides. Apparently the σ-bond contribution is larger in Pt(IV) than in Pt(II) complexes. When I was oxidized to II (X = Br) and, this subsequently became reduced, the product obtained was identical with the starting material. The complexes did not rearrange on oxidation and the nature of the X in II did not affect the Pt-N bonds. The νPt-N of trans isomers were at ∼525-31 cm.-1 for Pt(II) or Pt(IV). For the complexes studied, the overall (σ + π) bond strength of Pt-N was approx. the same in Pt(II) and Pt(IV) complexes.

Although many compounds look similar to this compound(15227-42-6)Formula: C10H10Cl2N2Pt, numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Redox-active films formed by electrochemical reduction of solutions of C60 and platinum complexes.Reference of cis-Dichlorobis(pyridine)platinum(II).

Electroreduction of a toluene-acetonitrile (4:1 volume/volume) solution of C60 and cis-Pt(py)2Cl2 in the presence of 0.10M tetra(n-butyl)ammonium perchlorate as supporting electrolyte produces a black, redox active film that coats the electrode surface. This film retains its redox activity when transferred to an acetonitrile solution that contains only the supporting electrolyte, 0.10M tetra(n-butyl)ammonium perchlorate. The film was characterized by IR spectroscopy, laser desorption mass spectrometry, and XPS spectroscopy. The formation of this film is dependent on the platinum complex used as precursor and on the potential range used during film growth. No film growth is observed when Pt(bipy)Cl2, Pt(py)2I2, cis-Pt(PPh3)2Cl2 or trans-Pt(py)2Cl2 were used as precursors, but {Pt(μ-Cl)Cl(C2H4)}2 is a useful precursor which allows film growth at less neg. potentials. Chem. prepared C60Pt1 is also electrochem. active when precipitated on a platinum electrode. The formation of an electroactive film from the electroreduction of C70 and cis-Pt(py)2Cl2 is also reported.

Although many compounds look similar to this compound(15227-42-6)Reference of cis-Dichlorobis(pyridine)platinum(II), numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Solid-phase condensation of coordinated pyridine and γ-picoline in platinum(II) complexes, the main research direction is thermolysis platinum picoline pyridine complex; condensation picoline pyridine coordinated platinum.SDS of cas: 15227-42-6.

The thermolysis of cis- and trans-[PtL2Cl2] (L = py, γ-picoline (pic)) was studied by IR and 1H NMR spectroscopy. cis-[PtL2Cl2] underwent cis-trans isomerization in the solid state at 200-220°. Thermolysis of trans-[PtL2Cl2] at 240-300° led to condensation of coordinated L to give PtL1Cl2 (L1 = 2,2′-bipyridine, 4,4′-dimethyl-2,2′-bipyridine). Thermolysis of [Pt(pic)4]Cl2 gave trans-Pt(pic)2Cl2 at 160°.

Compounds in my other articles are similar to this one(cis-Dichlorobis(pyridine)platinum(II))SDS of cas: 15227-42-6, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Kukushkin, Yu. N.; Postnikova, E. S. published the article 《Thermal decomposition of pyridine complexes of platinum (II)》. Keywords: thermal decomposition platinum pyridine complex; decomposition thermal platinum pyridine complex; pyridine platinum complex thermal decomposition; platinum pyridine complex decomposition; chloride platinum pyridine complex decomposition; chloride platinum pyridine complex decomposition; geometric isomer platinum pyridine complex; isomer geometric platinum pyridine complex.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Application of 15227-42-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

Thermal anal. of the decomposition of [Pt(py)4]Cl2.3H2O shows that in the initial stage of the reaction there is a joint loss of 2 mols. of pyridine and the H2O of crystallization As a result, trans-[Pt(py)2Cl2] is obtained. The cis-form is somewhat less thermally stable than the trans form. Upon thermal treatment of [Pt(py)4][PtCl4] at 195°, a mixture of geometric isomers of [Pt(py)2Cl2] is obtained.

Compounds in my other articles are similar to this one(cis-Dichlorobis(pyridine)platinum(II))Application of 15227-42-6, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Luminescence properties of some platinum(II) complexes. Counter-ion and molecular geometry effects.HPLC of Formula: 15227-42-6.

Reflectance and luminescence spectra, and emission lifetimes of 14 charged and neutral Pt(II) crystalline complexes are reported. The lifetimes (in the range of some tens of μsec) indicate that the emissions are due to a spin-forbidden process. On the basis of spectral correlations, the phosphorescence is tentatively identified as due to the lowest d-d ligand field transition when the bonding of the ligand is essentially σ in character, and to a π* → d charge-transfer transition for those complexes in which the ligands themselves have π orbital systems. Both the radiative (kr) and nonradiative (kn) rate constants are sensitive to changes in mol. geometry (cis,trans isomers) and counter-ions. By assuming unitary efficiency for the intersystem crossing to the emitting state, the counter-ion appears to predominantly affect kn through vibrational coupling of the chromophore with the lattice. For the cis forms, both kr and kn are affected in a complex manner, with metal-metal interactions playing an important role. For the trans forms, however, the constancy of the quantum yield with respect to temperature suggests that kn is negligible in comparison to kr, and therefore the trans chromophores behave as isolated systems within the crystalline lattice.

Compounds in my other articles are similar to this one(cis-Dichlorobis(pyridine)platinum(II))HPLC of Formula: 15227-42-6, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Activation of the trans geometry in platinum antitumor complexes. Synthesis, characterization, and biological activity of complexes with the planar ligands pyridine, N-methylimidazole, thiazole, and quinoline. Crystal and molecular structure of trans-dichlorobis(thiazole)platinum(II), the main research direction is antitumor platinum chloro nitrogen donor complex; crystal structure platinum chloro thiazole complex.Product Details of 15227-42-6.

The presence of planar ligands in trans-[PtCl2(py)2] greatly enhances the cytotoxicity of such species, with respect both to their corresponding cis isomer and also to trans-[PtCl2(NH3)2]. The cytotoxicity of trans-[PtCl2(py)2] in murine tumor cell lines is equivalent to the anticancer drug cisplatin, cis-[PtCl2(NH3)2]. The generality of this effect was studied for a range of structures with planar ligands of formula trans-[PtCl2(L)(L’)]. Three distinct series were examined-(1) L = L’ = py, N-methylimidazole (N-MeIm), and thiazole (Tz), (2) L = quinoline (quin), L’ = MeRSO where (R = Me, CH2Ph, Ph), and (3) L = quinoline, L’ = NH3. The synthesis and chem. characterization of all new complexes are described. An x-ray crystal structure determination for trans-[PtCl2(Tz)2] confirmed the geometry with N-bound thiazole. The crystals are monoclinic, space group C2/c, a 8.088(3), b 14.964(4), c 8.847(2) Å, β 99.50(2), Z = 4, R = 0.0545, Rw = 0.0655. Pt has the expected square planar coordination with l(Pt-Cl) = 2.300(5) Å and l(Pt-N) = 2.024(18) and 2.077(17) Å. Bond angles are normal with N(1)-Pt-N(2) = 180.0(1)°, N(1)-Pt-Cl(1) = 90.4(1)°, and N(2)-Pt-Cl(1A) = 89.6(1)°. The intensity data were collected with MoKα radiation with λ = 0.71073 Å. The thiazole rings are not coplanar but slightly tilted to each other at an angle of 14.3°. The dihedral angles between the Pt coordination plane and the thiazole rings are 119.3 and 105.0°. The biol. studies confirm the generality of activation of the trans geometry using planar ligands. Cytotoxicity tests in murine leukemia (L1210) cell lines both sensitive and rendered resistant to cisplatin show that the complexes show equivalent cytostatic activity to that of cisplatin. The activity is an order of magnitude greater than trans-[PtCl2(NH3)2]. The cytotoxicity is further marked by consistent activity in the cisplatin-resistant cell line. Contrary to the well-established but empirical structure-activity relationships, the trans geometry can give platinum complexes with cytotoxicity equivalent to that of the analogous cis isomer. The results point to a further source of platinum antitumor complexes acting by a different mol. mechanism to cisplatin with potential for antitumor activity complementary to that of the clin. used drug.

Compounds in my other articles are similar to this one(cis-Dichlorobis(pyridine)platinum(II))Product Details of 15227-42-6, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem