Category: 15227-42-6

Norden, Bengt published the article 《Rearrangement of a platinum(II) complex in DNA from intercalation outer-sphere position to non-intercalation coordination》. Keywords: DNA interaction platinum dipyridine complex.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Application of 15227-42-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

The interaction of I with DNA was studied using linear dichroism and absorption spectra of DNA solutions containing different concentrations of I. The initial complex had a stability constant of 3 × 105M-1 and the orientation of the I plane was angular, indicating that binding was by intercalation. This intercalated complex slowly transformed into a more stable complex with the orientation of the I plane parallel to the helix axis. In this complex there was coordination of I to N atoms of DNA bases. This complex involved the inner sphere of DNA. When II interacted with DNA, a complex was formed in which inner sphere coordination was present; II did not intercalate with DNA.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: cis-Dichlorobis(pyridine)platinum(II). The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Mass spectrometry of cis-platin in urine. Author is Sumino, Kimiaki; Mio, Takaya; Yamamoto, Ryoji; Ishigami, Joji; Kamidono, Sadao; Hamami, Gaku.

The mass spectra of cisplatin  [15663-27-1] and its analogs are presented. A urine sample of a cancer patient treated with cisplatin was extracted with 0.1N-HCl and then washed with COMe2/CHCl3. The component containing Pt was eluted with 2N-HBr using an ion exchange chromatog. technique. The mass spectrum of the component showed the change from Cl-type to Br-type as the unchanged type of carrier ligand. Thus, mass spectrometry may be a useful method to elucidate the action mechanism of cisplatin.

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HPLC of Formula: 15227-42-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Electrochemical properties of MC60 (M=Pd, Pt) covered electrodes. Author is De Bettencourt-Dias, Ana; Winkler, Krzysztof; Hayashi, Akari; Balch, Alan L..

The formation of electroactive films containing [60]fullerene and Pd or Pt was observed for solutions with the C60 and different metal complexes, Pd(PhCN)2Cl2, [Pd(CH3CO2)2]3, Pd(CH3CO2)2, [Pt(μ-Cl)Cl(C2H4)]2, cis-PtCl2(py)2, trans-PtCl2(py)2, and PtI2(py)2. Characterization of the film compositions by IR spectroscopy, MS and XPS shows that the films contain solely C60 and metal, as well as cations of the supporting electrolyte of the growth solution, that get incorporated during the cathodic growth process. Scanning electron micrographs of the films show that these consist mainly of spheres of ∼100 nm diameter and that the film thickness can be controlled by the number of cycles used during the growth process. The films show conductivity in the potential range of growth and this conductivity is both electronic and ionic and have thus potential application in high-d. energy storage devices.

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Tetrahydroisoquinoline – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Interactions of an antitumor platinum compound with deoxyribonucleic acid, histones, L-amino acids, poly(L-amino acids), nucleosides, and nucleotides, published in 1973, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Synthetic Route of C10H10Cl2N2Pt.

The antitumor agents cis-dichloro(dipyridine)platinum(II) [15227-42-6] and cis-dichlorodiammineplatinum(II) [15663-27-1] interacted not only with DNA but also with amino acids, histones, polyamino acids, nucleosides, and nucleotides. The platinum complexes apparently associated with electron-rich areas of the various components. Such interactions could significantly affect pool levels of these cell components, cellular metabolism, and the pharmacol. action of the platinum compounds

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Tetrahydroisoquinoline – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Microcalorimetric studies of the thermal decomposition of ammonia-halide and amine-halide complexes of platinum(II), [Pt(NH2R)2X2]》. Authors are Al Takhin, Ghassan; Skinner, Henry A.; Zaki, Ahmed A..The article about the compound:cis-Dichlorobis(pyridine)platinum(II)cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2).SDS of cas: 15227-42-6. Through the article, more information about this compound (cas:15227-42-6) is conveyed.

The standard heats of formation of the crystalline compounds [PtL2X2] [L = NH2R (R = H, Me, CHMe2, Bu, Et, Pr, CH2CHMe2), en, pyridine; X = Cl, Br, I] were derived from the enthalpies of thermal decomposition of their cis isomers at elevated temperatures The enthalpy of sublimation (ΔHsub) of [PtL2Cl2] (L = pyridine) is estimated as 170 kJ/mol, which gives an average pyridine-Pt bond-dissociation enthalpy of 122 kJ/mol in the gas phase. For other amine ligands, the bond-dissociation enthalpy is less than for the pyridine complex, falling to a min. of 97 kJ/mol for NH3. These imply sublimation heats of 270-300 kJ/mol in the Cl complexes.

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Tetrahydroisoquinoline – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ghezzi, AnnaRita; Aceto, Maurizio; Cassino, Claudio; Gabano, Elisabetta; Osella, Domenico researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Computed Properties of C10H10Cl2N2Pt.They published the article 《Uptake of antitumor platinum(II) complexes by cancer cells, assayed by inductively coupled plasma mass spectrometry (ICP-MS)》 about this compound( cas:15227-42-6 ) in Journal of Inorganic Biochemistry. Keywords: uptake antitumor platinum complex lipophilicity MCF7 cell. We’ll tell you more about this compound (cas:15227-42-6).

A systematic study on intracellular Pt uptake and Pt accumulation ratio in breast cancer MCF-7 cell line has been performed on a number of Pt(II)-complexes, namely cisplatin, carboplatin and oxaliplatin, clin. employed as antitumor drugs, trans- and cis-[Pt(Cl)2(pyridine)2] and cis-[Pt(Cl)2(pyridine)(5-SO3H-isoquinoline)] complexes, previously investigated also as potential telomerase inhibitors. In particular, long incubation times have been chosen in order to understand the fate of the complexes in the cells. For this purpose, sub-acute drug concentrations must be employed and, therefore, a very sensitive method of anal. like as inductively coupled plasma mass spectrometry (ICP-MS) superior to the widely employed at. absorption spectroscopy (AAS) has been adopted. Any relationships among uptake/accumulation and several parameters such as drug structure, lipophilicity, drug concentration and incubation time have been sought and analyzed: the bulk of data point for a passive diffusion mechanism through the cell membrane.

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Reference of cis-Dichlorobis(pyridine)platinum(II). So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Volumes of activation for the substitution reactions of cis- and trans-[PtL2(Cl)X] with pyridine in various solvents.

The pressure dependence of the 2nd-order rate constant for the substitution of pyridine for Cl in trans-[Pt(py)2(Cl)(NO2)] was measured in the solvents nitromethane, methanol, ethanol, and dichloromethane. The resp. ΔV*exptl. values were calculated to be -6.2 ± 0.4 at 10°, -8.8 ± 0.6 at 25°, -13.1 ± 0.8 at 25°, and -19.8 ± 1.7 cm3 mol-1 att 25°. The ΔVexptl. values for the corresponding reactions of cis-[Pt(py)2(Cl)(NO2)] and trans-[Pt(PEt3)2Cl2] in methanol at 25° are -5.5 ± 0.5 and -13.6 ± 0.8 cm3 mol-1, resp. These ΔV*exptl.’s were found to be only slightly temperature dependent. The activation parameters ΔH*2 and ΔS*2 were also determined for each reaction. The volume change associated with the partial formation of the Pt-pyridine bond was estimated to be -4 ± 1 cm3 mol-1. A qual. explanation of the solvent dependence of ΔV*exptl. is also given.

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Application of 15227-42-6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about The separation of nonelectrolytic geometric isomers of platinum(II) by thin-layer chromatography. Author is Kauffman, George B.; Benson, Barrett W..

Microscope slides (75 × 25 mm.) were cleaned with detergent, rinsed in H2O, and coated with a slurry containing 1 part Silica Gel G in 3 parts of a 1:1 volume mixture of MeOH and redistilled CH2Cl2. The plates were air dried for 10-20 min. and activated for 1 hr. at 110°. Saturated solutions of the cis isomers, trans isomers, and a 1:1 by weight mixture of both Pt isomers in CH2Cl2 were applied to the plate. The plate was air dried for 2-3 min. and then developed with an ascending technique until the solvent had attained ∼6 cm. The plate was then air dried and the intense yellow-spots detected in a screw-cap jar containing I. The difference of the cis and trans migrations. ΔRf, indicated the effectiveness of separation For [Pt(Et2S)2Cl2] developed in C6H6, CH2Cl2, and 19:1 mixture of C6H6:Me2CO, ΔRf was 0.45, 0.45, and 0.45, resp. For [Pt(Bu3P)2Cl2] developed in C6H6, CH2Cl2, and a 1:1 mixture of C6H6:CH2Cl2 ΔRf was 0.95, 0.55 and 0.80, resp. For [Pt(pyridine)2Cl2] developed in CH2Cl2, 5:1 of C6H6:Me2CO Me2CO, and 5:1 of CH2Cl2:Me2CO ΔRf was 0.20, 0.45, and 0.35 resp. For [(Pr3P)2Pt2(PhS)2Cl2] developed in C6H6 and CH2Cl2 ΔRf was 0.40 and 0.45, resp. For [(Pr3P)2Pt(EtS)2Cl2] developed in CH2Cl2, 1:2 of C6H6:CH2Cl2, and C6H6 ΔRf was 0.40, 0.40, and 0.30, resp. For [Pr3P)2Pt2(p-O2NC6H4S)2Cl2] developed in CH2Cl2 and 2:1 of C6H6:Me2CO ΔRf was 0.30, 0.20, and 0.10, resp. Two (200 × 100 mm.) silica gel plates were prepared A mixture of 100 mg. cis and 100 mg. trans [Cl2Pt(PBu3)2] in CH2Cl2 were applied to the plates and developed with C6H6. The bands at Rf 0.0-0.1 and 0.85-0.10 were removed and eluted with Me2CO and CH2Cl2, resp. Evaporation yielded 91% cis isomer and 93% trans isomer. Thus, complete separation had been achieved with solvent induced isomerization.

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Product Details of 15227-42-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Nucleophilic displacement of the chelating bis(sulfoxide) from cis-[meso-1,2-bis(phenylsulfinyl)ethane]dichloroplatinum(II) and cis-[rac-1,2-bis(phenylsulfinyl)ethane]dichloroplatinum(II). Author is Cattalini, Lucio; Marangoni, Giampaolo; Michelon, Gianni; Paolucci, Gino; Tobe, Martin L..

The kinetics were measured for ring opening of the title Pt complex isomers by amines in 1,2-dimethoxyethane solutions The results are used in a discussion of the differences between the 2 isomers in comparison with other Pt(II) complexes in terms of absolute reactivity, nucleophilic discrimination, and steric retardation effects.

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Quality Control of cis-Dichlorobis(pyridine)platinum(II). The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Interaction of cis platinum(II) compounds with poly(L-glutamate). A doubly anchored spin-label and a doubly anchored chromophore-label. Author is Chao, Yen Yau H.; Holtzer, Alfred; Mastin, Stephen H..

The free-radical 4-amino-2,2,6,6-tetramethylpiperidinyl-1-oxy [14691-88-4] yields cis-Pt(ATMPO)2(NO3)2 [64716-94-5], which is used to label poly(L-glutamate) (I), poly(L-aspartate) (II), and poly(L-lysine) (III). Labeling occurs by displacement of nitrate by polymer side chains. EPR spectra of oriented films of labeled I are strongly anisotropic; several arguments suggest that the major cause is g anisotropy. Spectra of solutions, in several solvents, of labeled I are also anisotropic and monitor the helix-coil transition and polymer aggregation. Since monofunctional, side-chain labels show only isotropic motions, Pt must be bifunctionally anchored to adjacent carboxylates, requiring the label to follow backbone segmental motions. With shorter side chains (II) adjacent double anchoring is impossible; with longer side chains (III), flexibility reduces coupling to backbone motion; in each, therefore, spectra are isotropic. Chromophoric compounds, particularly cis-Pt(bipy)(H2O)2][NO3]2 [64800-95-9], are similarly used. Bifunctional attachment is evidenced by the absence of base-induced UV spectral shifts (characteristic of attachment of OH- to Pt) shown by label alone, and by similarity of the spectra of labeled polymer and labeled oxalate. Induced CD appears for α helix in the region of the chromophore π-π* bands; transition to random coil drastically reduces this CD. With extensively labeled polymer differences in the course of the helix-coil transition as monitored by CD in the backbone region with that monitored in the chromophore region show that the label stabilizes its attached helical residue. A study of Corey-Pauling-Koltun models and extant theories suggests that the induced CD arises by coupling of the carboxylate π-π* and the bound chromophore 1B1 elec. transition moments.

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