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A preparation method of the compound alpha – phosphoramidate (by machine translation)

The invention discloses a method for preparing alpha – phosphoramidate compounds, low molecular alcohol as the reaction solvent, by N – phenyl – 1, 2, 3, 4 – tetrahydroisoquinoline and phosphorous acid dialkyl ester as the raw material, and then adding the iron catalyst, in order to air as the oxidizing agent fully stir the reaction, the reaction reaches the end point, separation, purification alpha – phosphoramidate compounds; the method not only mild reaction conditions, the operability is strong, low cost, high safety, environmental protection, but also the reaction conversion and yield is high, the process flow is short, the reaction scale is easy to expand, simple product separation, has the advantage of being suitable for industrial production. (by machine translation)

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Enantioselective metal/organo-catalyzed aerobic oxidative sp3C-H olefination of tertiary amines using molecular oxygen as the sole oxidant

An organocatalysis/copper-catalyzed asymmetric oxidative sp3 C-H olefination reaction of tertiary amines with olefins using molecular oxygen as the sole oxidant under mild conditions was realized for the first time. This novel strategy provides an efficient and environmentally friendly way to access diversify optically active C1-alkene tetrahydroisoquinoline derivatives.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Iron-Catalyzed Cyclization of Ketoxime Carboxylates and Tertiary Anilines for the Synthesis of Pyridines

A novel and efficient iron-catalyzed cyclization of ketoxime carboxylates and N,N-dialkylanilines for the modular synthesis of diverse pyridines was developed. The reaction was initiated by Fe-catalyzed N-O bond cleavage of ketoxime carboxylates in the presence of tertiary anilines. The methylene carbon on N,N-dialkylanilines functioned as a source of one-carbon synthon in the reaction. The reaction used readily available starting materials, tolerated various functional groups, and afforded 2,4-disubstituted and 2,4,6-trisubstituted pyridines in good to high yields under mild conditions.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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alpha-Angelica Lactone in a New Role: Facile Access to N-Aryl Tetrahydroisoquinolinones and Isoindolinones via Organocatalytic alpha-CH2 Oxygenation

A method for the direct oxidation of various N-aryl tetrahydroisoquinolines and isoindolines to the corresponding lactams using alpha-angelica lactone as a catalyst was developed. The utility of the method was further demonstrated by synthesis of indoprofen and indobufen.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Platinum-catalyzed cross-dehydrogenative coupling reaction in the absence of oxidant

A third strategy for cross-dehydrogenative coupling reaction has been reported via platinum-catalyzed sp3 C-H and sp3 C-H coupling reaction in the absence of oxidant. Nitroalkanes as well as dialkyl malonate derivatives, beta-keto esters and malononitrile are active participants in this coupling reaction. Both cyclic and acyclic non-activated simple ketones are good reactants in this reaction.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Synthetic method of tetrahydroisoquinoline derivatives

The manufacturing method reel [thu [thu] high draw child small quinoline derivatives disclosure in the nanometer range. The present invention refers to, metal-based dye and visible light from high draw child small quinoline Mannich derivatives in high yield and short time in high draw child small quinoline (tetrahydroisoquinoline) 2 2 efficiently number can be characterized as having a high pressure liquid coolant. (by machine translation)

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Thiourea-Catalyzed Cross-Dehydrogenative Coupling of C(sp3)?H with Diethyl Phosphite

The efficient thiourea-catalyzed cross-dehydrogenative coupling of C(sp3)?H with diethyl phosphite by using tert-butyl peroxide as a terminal oxidant was explored. This protocol further expands the application scope of H-bond donors and also provides facile access to biologically relevant alpha-amino phosphonic derivatives.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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3340-78-1, Name is 2-Phenyl-1,2,3,4-tetrahydroisoquinoline, belongs to tetrahydroisoquinoline compound, is a common compound. SDS of cas: 3340-78-1In an article, once mentioned the new application about 3340-78-1.

Rapid Microwave-Assisted Synthesis of N-Aryl 1,2,3,4-Tetrahydroisoquinolines

N-aryl 1,2,3,4-tetrahydroisoquinolines were prepared rapidly in good yields by the microwave-assisted Pd-catalysed coupling of (hetero)aryl iodides or bromides with 1,2,3,4-tetrahydroisoquinoline. Reactions were typically complete within 5 min for aryl iodides and within 30 min for pyridyl bromides.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Cu(I)-catalyzed one-pot decarboxylation-alkynylation reactions on 1,2,3,4-tetrahydroisoquinolines and one-pot synthesis of triazolyl-1,2,3,4-tetrahydroisoquinolines

A facile and efficient method to introduce alkyne groups to the C-1 position of biologically interesting 1,2,3,4-tetrahydroisoquinolines via direct C[sbnd]H-functionalization is reported. Various alkynylated N-substituted 1,2,3,4-tetrahydroisoquinolines could be obtained by using copper(I)-chloride as catalyst, alkynoic acids as alkyne source and t-BuOOH as oxidant, in a one-pot two-step decarboxylation- alkynylation reaction in moderate to high yields. Furthermore, a one-pot protocol of a three-step decarboxylation-alkynylation-1,3-dipolar cycloaddition reaction leading to 1-triazolyl-tetrahydroisoquinolines was developed, a hitherto unknown reaction cascade.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Covalent organic frameworks as metal-free heterogeneous photocatalysts for organic transformations

Two-dimensional covalent organic frameworks (2D-COFs) are excellent candidates for photocatalytic organic transformations due to their periodic columnar pi-arrays and ordered nanochannels. Here, we present a novel 2D-COF that features permanent porosity with high surface area and large pore volume, and exhibits a high crystallinity and an excellent stability. Indeed, the new 2D-COF was found to be a highly efficient, metal-free, recyclable heterogeneous photocatalyst for oxidative C-H functionalizations under visible-light irradiation using O2 as a green oxygen source.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem