Category: 57060-88-5

57060-88-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride, cas is 57060-88-5,the tetrahydroisoquinoline compound, it is a common compound, a new synthetic route is introduced below.

To a solution of Boc-Dmt-OH (309 mg, 1 mmol), HBTU (379 mg, 1 mmol) and DIEA (348 muL, 2 mmol) in 5 mL DMF was added a solution of HCl x H-Tic-OMe (227.5 mg, 1 mmol) and DIEA (174 muL, 1 mmol) in 5 mL DMF. The reaction mixture was stirred for 5 h at room temperature and progress of the reaction was monitored by TLC. After solvent evaporation in vacuo, the residue was dissolved in 50 mL AcOEt and the resulting solution was washed with 5% KHSO4 (aq.), saturated NaHCO3 (aq.) and brine. The organic phase was dried (MgSO4), filtered and evaporated to dryness, yielding 430 mg of crude product (90% yield). The crude Boc-protected dipeptide ester was deprotected by treatment with aqueous TFA (95% vv) for 45 min under stirring and cooling with ice. After TFA evaporation in vacuo, the TFA salt of the dipeptide ester was precipitated with ether (Et2O), affording 300 mg (90% yield) of crude product which was purified by preparative HPLC. TFA x H-Dmt-Tic-OMe: TLC Rf (I) 0.55; MS [M+H]+ 383.

The chemical industry reduces the impact on the environment during synthesis,57060-88-5,Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride,I believe this compound will play a more active role in future production and life.

Reference£º
Article; Weltrowska, Grazyna; Nguyen, Thi M.-D.; Chung, Nga N.; Wilkes, Brian C.; Schiller, Peter W.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 18; (2013); p. 5082 – 5085;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

57060-88-5,Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride, cas is 57060-88-5, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.

To a solution of Boc-Dmt-OH (309 mg, 1 mmol), HBTU (379 mg, 1 mmol) and DIEA (348 muL, 2 mmol) in 5 mL DMF was added a solution of HCl x H-Tic-OMe (227.5 mg, 1 mmol) and DIEA (174 muL, 1 mmol) in 5 mL DMF. The reaction mixture was stirred for 5 h at room temperature and progress of the reaction was monitored by TLC. After solvent evaporation in vacuo, the residue was dissolved in 50 mL AcOEt and the resulting solution was washed with 5% KHSO4 (aq.), saturated NaHCO3 (aq.) and brine. The organic phase was dried (MgSO4), filtered and evaporated to dryness, yielding 430 mg of crude product (90% yield). The crude Boc-protected dipeptide ester was deprotected by treatment with aqueous TFA (95% vv) for 45 min under stirring and cooling with ice. After TFA evaporation in vacuo, the TFA salt of the dipeptide ester was precipitated with ether (Et2O), affording 300 mg (90% yield) of crude product which was purified by preparative HPLC. TFA x H-Dmt-Tic-OMe: TLC Rf (I) 0.55; MS [M+H]+ 383.

With the rapid development of chemical substances, we look forward to future research findings about Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride

Reference£º
Article; Weltrowska, Grazyna; Nguyen, Thi M.-D.; Chung, Nga N.; Wilkes, Brian C.; Schiller, Peter W.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 18; (2013); p. 5082 – 5085;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

As a common heterocyclic compound, it belongs to tetrahydroisoquinoline compound, name is Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride, and cas is 57060-88-5, its synthesis route is as follows.,57060-88-5

To a stirred solution of methyl 1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride (4.5 g) in dichloromethane (150 mL) was added triethylamine (6.1 mL) and 3-methoxy-4-tert-butylbenzoyl chloride (5.0 g) and the resultant mixture was stirred at room temperature for 18 hours. The reaction mixture was washed with saturated aqueous sodium bicarbonate solution and was then dried and evaporated to gum. This material was purified using chromatography over silica gel eluting with ethyl acetate/cyclohexane (15:85 v/v). Appropriate fractions were combined and evaporated to give the title compound. MS calcd for (C23H27NO4 + H)+: 382 MS found (electrospray) (M+H)+ = 382.

With the complex challenges of chemical substances, we look forward to future research findings about 57060-88-5,belong tetrahydroisoquinoline compound

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/96774; (2004); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57060-88-5,Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.,57060-88-5

Methyl 1 ,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride (3g, 13.17 mmol) and potassium carbonate (3.6g, 26.34 mmol) were taken in acetone (250 mL). 2,4,6-trimethylbenzenesulfonyl chloride (3.5g, 15.8 mmol) was added to the reaction mixture and stirred at ambient temperature for 1 6h. Crude reaction mixture was concentratedunder reduced pressure, extracted with saturated bicarbonate and brine, dried and concentrated. The crude mixture was purified on silica using ethyl acetate-hexane (40-60) to obtain the title compound (4.5g, 92% yield). ?H NMR (400 MHz, DMSO-d6) oe ppm 2.27 (s, 3 H) 2.54 (s, 6 H) 3.14 (d, J=3.42 Hz, 3 H) 4.32 – 4.50 (m, 2 H) 4.77 – 4.83 (m, 1 H) 7.08 (s, 2 H) 7.17 (s, 4H). MS (m/z): 374.1 (M+H).

57060-88-5 Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride 12248067, atetrahydroisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; SAINT LOUIS UNIVERSITY; BURRIS, Thomas; WALKER, Jonn, K.; FLAVENY, Colin; CHATTERJEE, Arindam; (117 pag.)WO2017/223514; (2017); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

57060-88-5, Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57060-88-5

(B) Methyl 2-[N2 -(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylate To a stirred solution of 1.8 g of methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride and 8 ml of triethylamine in 50 ml of chloroform which was cooled in an ice bath, there was carefully added N2 -(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl chloride hydrochloride obtained above. The reaction mixture was allowed to stand overnight at room temperature. The reaction mixture was washed twice with 50 ml of saturated sodium chloride solution and evaporated to dryness. The residue was dissolved in water-ethanol and ajusted to pH 12 with 5N NaOH solution at a temperature below 0 C to precipitate a solid. This was collected by filtration to give 3 g of methyl 2-[N2 -(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylate. I.R. (KBr): 3,350, 1,740, 1,640, 1,260, 1,160 cm-1. Analysis-Calcd. for C29 H35 O7 N5 S1 (percent): C, 58.27; H, 5.90; N, 11.72. Found (percent): C, 58.45; H, 6.03; N, 11.53.

As the paragraph descriping shows that 57060-88-5 is playing an increasingly important role.

Reference£º
Patent; Mitsubishi Chemical Industries Ltd.; Okamoto; Shosuke; US4104392; (1978); A;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57060-88-5,Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.,57060-88-5

Step A: Preparation of Methyl 1,2,3,4,4a,5,6,7,8,8a-Decahydroisoquinoline-3-carboxylate Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride (2.3 g, 10 mmol) in 200 ml absolute ethanol is hydrogenated at 50 psi, room temperature, using 0.6 g 5% Rh/C catalyst. After the theoretical amount of hydrogen is taken up (36 hours), the catalyst is filtered and the filtrate is evaporated to dryness. The residue is dissolved in methylene chloride and washed with a saturated solution of sodium carbonate. The organic phase is dried (Na2 SO4) and acidified with ethanolic HCl. Evaporation of the solvent yields 2.0 g of the product as a diastereomeric mixture which is used without further separation.

57060-88-5 Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride 12248067, atetrahydroisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Merck & Co., Inc.; US4381302; (1983); A;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57060-88-5,Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.,57060-88-5

To a stirred solution of methyl 1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride (4.5 g) in dichloromethane (150 mL) was added triethylamine (6.1 mL) and 3-methoxy-4-tert-butylbenzoyl chloride (5.0 g) and the resultant mixture was stirred at room temperature for 18 hours. The reaction mixture was washed with saturated aqueous sodium bicarbonate solution and was then dried and evaporated to gum. This material was purified using chromatography over silica gel eluting with ethyl acetate/cyclohexane (15:85 v/v). Appropriate fractions were combined and evaporated to give the title compound. MS calcd for (C23H27NO4 + H)+: 382 MS found (electrospray) (M+H)+ = 382.

As the paragraph descriping shows that 57060-88-5 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/96774; (2004); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57060-88-5,Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.,57060-88-5

Example 38; 2-[2-(3-Carboxy-6,8-dichloronaphthalen-1-yloxy)-acetyl]-1, 2,3,4- tetrahydroisoquinoline-3-carboxylic acid[00122] The title compound is prepared by the following reaction sequence: a) a mixture of 1 ,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester hydrochloride (10bc) (108 mg, 0.47 mmol), 5,7-dichloro-4- chlorocarbonylmethoxynaphthalene-2-carboxylic acid methyl ester (9a) (150 mg, 0.43 mmol) and TEA (0.21 mL, 5.51 mmol) in CH2CI2 (4 ml_) is stirred at rt for 3 days. After evaporation under reduced pressure, the residue is purified by flash chromatography to give 2-[2-(6,8-dichloro-3-methoxycarbonylnaphthalen-1 -yloxy)-acetyl]-1 ,2,3,4- tetrahydroisoquinoline-3-carboxylic acid methyl ester (13bi) (207 mg, 95%).

The synthetic route of 57060-88-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERZ PHARMA GMBH &; CO. KGAA; HENRICH, Markus; BAUER, Angela; NAGEL, Jens; KAUSS, Valerjans; TRIFANOVA, Dina; GRUNSTEINE, Ginta; ROZHKOVS, Jevgenijs; WO2010/139481; (2010); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem