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Benzodiazepine derivatives

The present invention provides benzodiazepine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of inhibiting activated blood-coagulation factor X. These compounds are usable as agents for treating various diseases concerned with the activated blood-coagulation factor X. 1

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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N-CYCLOPROPYL-N-PIPERIDYLBENZAMDES AS GPR119 MODULATORS

The present invention relates to compounds of general formula I, wherein the groups R1, LP, LQ, Ar, m and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Fourfold-Interpenetrated MOF [Ni(pybz)2] as Coating Material in Gas Chromatographic Capillary Column for Separation

A fourfold interpenetrated diamond-like topological metal-organic framework (MOF), Ni(pybz)2 [pybz = 4-(4-pyridyl)benzoate] was successfully synthesized and fully characterized. This MOF can serve as coating material in gas chromatographic capillary column for the separation of some low boiling point essential oils. The prepared columns have good recognition ability and excellent selectivity toward a series of organic compounds, including alcohols, aldehydes, ketones, carboxylic acid, ethers, ester, and amines. It is found that the strained metal sites, van der Waals interactions, C-H?pi attraction, and weak nonclassical hydrogen bond contribute to the recognition and selectivity of prepared columns. The grand canonical Monte Carlo technique is used to simulate the interactions of the adsorbates with MOF. The calculated van der Waals energies agree with the results of gas chromatographic separation.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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5-ARYL-1,3,4-OXADIAZOLE-2-AMINES AS NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS

The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and their use in the treatment of neurological, psychiatric disorders and gastrointestinal disorders. wherein R 1 and R 2 independently represent hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; or R 1 and R 2 together with the nitrogen atom to which they are attached form a nitroge containing heterocyclyl group which is unsubstituted or substituted with 1, 2, or 3 substituents selected from methyl or fluoro; Q represents -(CH 2 ) n- wherein n represents 3 or 4; A represents a phenyl ring and B represents a 5 or 6 membered heteroaryl ring or B represents a phenyl ring and A represents a 5 or 6 membered heteroaryl ring; R 3 and R 4 independently represent C 1-6 alkyl, C 1-6 alkoxy and halo; t and m independently represent an integer from 0 to 3. Compounds of formula (I) and their pharmaceutically acceptable salts may have affinity for and be agonists at the nicotinic alpha 7 receptor and are believed to be of potential use in the treatment of neurological diseases including Alzheimer’s disease.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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NOVEL SULFONYL DERIVATIVES

Sulfonyl derivatives represented by the following general formula (I): Q1-Q2-T1-Q3-SO2-QAand drugs containing the same (wherein Q1is an optionally substituted, saturated or unsaturated, five- or six-membered cyclic hydrocarbon group, a five- or six-membered heterocyclic group, or the like; Q2is a single band, oxygen, sulfur, C1-C6alkylene or the like; QAis optionally substituted arylalkenyl, heteroarylalkenyl or the like; and T1is carbonyl or the like). These compounds have potent FXa-inhibitory effects and promptly exert satisfactory and persistent antithrombotic effects through oral administration, thus being useful as anticoagulant agents little accompanied with side effects.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists-Increasing selectivity over hERG

Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists with greater selectivity over hERG were identified. SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity are described.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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New Process

A new process for the preparation of 4-(4-pyridinyl)benzoic acid, or a salt thereof.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Heterometallic coordination polymers constructed by linear ligands

Eight lanthanide-copper coordination polymers of linear rigid 4-(4-pyridyl)benzoate(L1) and isonicotinate(L2), [LnCuI(L1)2(OAc) (H2O)]n (Ln = Pr, 1; Nd, 2; Sm, 3; Eu, 4; Gd, 5), [Ln2Cu4I 3(L2)7 (H2O)]n (Ln = La, 6; Pr, 7), and [Nd2Cu7I6(L2) 7 (H2O)6]n¡¤2.5nH2O (8), were hydrothermally synthesized and structurally characterized by single-crystal X-ray diffraction. The three-dimensional frameworks of 1-5 can be described as wave-like layer modules of [Ln(L1)2(OAc) (H2O)]n linking with each other through dimeric units of Cu2I2, whereas that of compounds 6 and 7 are constructed by layer modules of [Ln2(L2)7(H 2O)]nn- and Cu4I3 clusters. As for 8, dimeric units of Nd2(L2)7(H2O)6 connect layered polymeric [Cu7I6]nn+ forming a 3D framework.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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COMPOUNDS AND METHODS

This invention relates to substituted heteroanilide compounds which are modulators, agonists or antagonists, of the CCR5 receptior. In addition, this invention relates to the treatment and prevention of disease states mediatd by CCR5.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Doped porous carbon nanostructures with N?Co?O catalytic active sites for efficient electrocatalytic oxygen reduction reaction

A cobalt metal-organic framework constructed by 4-(4-pyridyl)-benzoic acid was used as the precursor to afford a series of Co nanoparticles embedded and N/O-doped porous carbon materials CoNOC-Tc-t (where Tc represents the carbonization temperature and t represents the carbonization time), which possess high surface area, hierarchically micro-, meso- and macropores, and high graphitization as well as the uniformly enchased N?Co?O catalytic active sites derived from pyridine nitrogen atom and chelating carboxylate coordinated octahedral cobalt (II) center. These CoNOC-Tc-t porous carbon nanostructures have demonstrated prominent catalytic activities toward oxygen reduction reaction (ORR) in alkaline medium. Compared with commercial Pt/C catalyst, the CoNOC-800-1 (annealed at 800 C for 1 h) exhibits excellent selectivity via an efficient four-electron-dominant ORR process, as well as the superior durability and methanol tolerance, making it a cost-effective Pt-free ORR electrocatalyst. More importantly, the novelly designed N?Co?O catalytic active sites are proposed and well demonstrated by experiments, which provides a promising approach to develop heteroatom-doped carbon-based electrocatalytic materials.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem