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The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and their use in the treatment of neurological, psychiatric disorders and gastrointestinal disorders. wherein R 1 and R 2 independently represent hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; or R 1 and R 2 together with the nitrogen atom to which they are attached form a nitroge containing heterocyclyl group which is unsubstituted or substituted with 1, 2, or 3 substituents selected from methyl or fluoro; Q represents -(CH 2 ) n- wherein n represents 3 or 4; A represents a phenyl ring and B represents a 5 or 6 membered heteroaryl ring or B represents a phenyl ring and A represents a 5 or 6 membered heteroaryl ring; R 3 and R 4 independently represent C 1-6 alkyl, C 1-6 alkoxy and halo; t and m independently represent an integer from 0 to 3. Compounds of formula (I) and their pharmaceutically acceptable salts may have affinity for and be agonists at the nicotinic alpha 7 receptor and are believed to be of potential use in the treatment of neurological diseases including Alzheimer’s disease.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Chemical Research Letters, May 2021. Research speed reading in 2021. Formula: C10H14ClNO, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 57196-62-0, Name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, molecular formula is C10H14ClNO. In a Patent，once mentioned of 57196-62-0

This invention is directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans that inhibit Factor Xa, pharmaceutical compositions comprising these compounds and their use for inhibiting Factor Xa or treating pathological conditions in a patient that may be ameliorated by administration of such compounds. This invention is also is also directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans which directly inhibit both Factor Xa and Factor IIa (thrombin), to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds and to a method of simultaneously directly inhibiting both Factor Xa and Factor IIa (thrombin).

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Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Chemical Research Letters, May 2021. name: 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.57196-62-0, Name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, molecular formula is C10H14ClNO. In a Article，once mentioned of 57196-62-0

C61H52Ag2N2O6P2, orthorhombic, P212121 (no. 19), a = 14.4634(11) A, b = 17.7866(18) A, c = 20.5509(19) A, V = 5286.8(8) A3, Z = 4, Rgt(F) = 0.0424, wRref(F2) = 0.0997, T = 298(2) K.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

New Advances in Chemical Research in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, and research on the structure and performance of functional materials.In a patent, 57196-62-0, name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, introducing its new discovery. Electric Literature of 57196-62-0

A Cp?Rh-based nonanuclear triangular macrocycle complex [(Cp?Rh)9L3(NO3)4.5(MeOH)](OTf)4.5 (1), a Cp?Ir-based trinuclear complex [(Cp?Ir)3L(MeCN)4](OTf)3 (2) and a linear heptanuclear heterometallic complex [(Cp?Ir)6ZnL2(MeCN)8(MeOH)2](OTf)8 (3) (Cp? = eta5-pentamethylcyclopentadienyl) have been synthesized from a 2-(4-(pyridin-4-yl)phenyl)-1H-imidazole-4,5-dicarboxylic acid proligand. These complexes were further characterized by X-ray crystallography, 1H NMR, DOSY NMR, IR spectroscopy, and elemental analyses.

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Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Chemical Research Letters, May 2021. Research speed reading in 2021. Recommanded Product: 57196-62-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 57196-62-0, Name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, molecular formula is C10H14ClNO. In a Article，once mentioned of 57196-62-0

The structural transformations of compound 1 {[Co(44pba)2] 4·(DMF)3·(EtOH) 0.25·(H2O)4}n [44pba = 4-(4-pyridyl) benzoate] were followed during the exchange of DMF and ethanol molecules by methanol at room temperature. The new phases obtained 2 {[Co(44pba)2]·(MeOH)2.5·(H 2O)}n, 3 {[Co(44pba)2(MeOH)2] 2·(MeOH)2.5·(H2O) 2}n and 4 {[Co(44pba)2(MeOH) 2]·(MeOH)0.5·(H2O) 0.5}n were studied using differential scanning calorimetry, thermogravimetric analysis and X-ray diffraction methods. The final phase 4 reverts back to 1 upon soaking 4 in a dry DMF-ethanol mixture as evidenced by the powder diffraction data and infrared spectra.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Research speed reading in 2021. An article , which mentions Related Products of 57196-62-0, molecular formula is C10H14ClNO. The compound – 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride played an important role in people’s production and life., Related Products of 57196-62-0

Sulfonyl derivatives represented by general formula (I), salts of the same, and solvates of both: and application of them as drugs: [wherein R1 is hydrogen, hydroxyl, nitro or the like; R2 and R3 are each independently hydrogen, halogeno or the like; R4 and R5 are each dependently hydrogen, halogeno or the like; Q1 is an optionally substituted saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group or the like; Q2 is a single bond, oxygen or the like; Q3 is, e.g., a group represented by formula (a): T1 is carbonyl or the like; and X1 and X2 are each independently methylidyne or nitrogen]. These compounds exhibit potent Fxa inhibiting activities and serve as excellent anticoagulants which speedily exert satisfactory and persistent anti-thrombotic effects through oral administration and little cause adverse effects.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Research speed reading in 2021. An article , which mentions Safety of 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, molecular formula is C10H14ClNO. The compound – 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride played an important role in people’s production and life., Safety of 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Under the cooperation of two linear organic ligands, a novel heterometal-organic framework [La2Cu2(ox) 2L6]·4HL (HL = 4-pyridin-4-ylbenzoic acid) with non-interpenetrated 3D pcu net was obtained. Notably, the neutral molecular HL species are observed as structure-directing agents, which in turn contribute to the stability of the framework. This journal is the Partner Organisations 2014.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

New research progress on 57196-62-0 in 2021. Recommanded Product: 57196-62-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 57196-62-0, molcular formula is C10H14ClNO, introducing its new discovery.

A highly stable face-extended cluster-organic framework incorporating infinite inorganic guests is hydrothermally constructed, in which the tetrahedral O-centred Cu4O cluster is firstly found as the face-extended structure building unit to further provide a diamondoid cluster-organic framework with high thermal and structural stability.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Chemical Research Letters, May 2021. Quality Control of 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.57196-62-0, Name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, molecular formula is C10H14ClNO. In a Article，once mentioned of 57196-62-0

Reverse-phase glass beads have been employed in Suzuki reactions to provide, in aqueous media, a route to diverse polar substrates in good yield and with low levels of palladium leaching.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

category: tetrahydroisoquinoline, New Advances in Chemical Research, May 2021. Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 57196-62-0, Name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride,introducing its new discovery.

This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem