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{[Cu6(pybz)8(OH)2]·I 5-·I7-}n (1), obtained hydrothermally by using iodine molecules as a versatile precursor template, consists of a cationic framework with two types of zigzag channels, which segregate I5- and I7- anions. The framework exhibits the first observed bipillared-bilayer structure featuring both interdigitation and interpenetration. 1 displays high framework stability in both acidic (HCl) and alkaline (NaOH) solutions. 1 slowly releases iodine in dry methanol to give [Cu6(pybz)8(OH)2](I -)2·3.5CH3OH (1′) and partially recovers iodine from cyclohexane to form [Cu6(pybz)8(OH) 2](I-)2·xI2 (1?). Differences of up to 100 times in electrical conductivity and of 4 times in nonlinear optical activity (NLO) have been measured between 1 and 1′. This compound is one of few displaying multifunctionality, electrical conductivity, NLO, and crystal-crystal stability upon release and recovery of iodine. It is also unique in the iodine release from polyiodide anions in a metal-organic framework.

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New discoveries in chemical research and development in 2021. In heterogeneous catalysis, the catalyst is in a different phase from the reactants. COA of Formula: C10H14ClNO, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 57196-62-0, name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride. In an article,Which mentioned a new discovery about 57196-62-0

The invention relates to a benzoic acid salt of methyl (2R,3R)-2-{3-[amino (imino) methyl]benzyl}-3-{[4-(1 -oxidopyridin-4-yl)benzoyl]amino}butanoate, and to a benzoic acid salt of methyl (2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1 -oxidopyridin-4- yl)benzoyl]amino}butanoate which is in a crystalline form or in at least partially crystalline form, as well as a process for the preparation of the same, methods of using such salt to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.

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Tetrahydroisoquinoline – Wikipedia,
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New Advances in Chemical Research in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, and research on the structure and performance of functional materials.In a patent, 57196-62-0, name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, introducing its new discovery. Synthetic Route of 57196-62-0

An one step approach to heteroaryl benzoic acids from readily accessible heteroaryl halides and carboxybenzene boronic acids is described. The Suzuki coupling is carried out in the presence of Pd(PPh3)4 and sodium carbonate in aqueous acetonitrile. The scope and limitations of the reaction are discussed.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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A new acylhydrazone fluorescence probe, SPBH, was synthesized from salicylaldehyde and 4-(pyridin-4-yl)benzohydrazide (PBH). SPBH exhibited high selectivity and a sensitive fluorescence response towards Al3+, even in the presence of other competing metal ions in DMF/H2O (1:1, v/v) medium. And, the chemosensor can even detect Al3+ in the intracellular region of human non-small cell lung cancer H460 cells. The binding phenomenon of SPBH was investigated by 1H NMR spectroscopy and HR-MS. Mass spectrometry analysis showed a 1:1 complex formation of SPBH with Al3+. The Job plot also confirmed its 1:1 interaction. This SPBH/Al3+ complex exhibited excellent fluorescence “turn-off” properties towards the F- anion. Thus, SPBH acts as a sequential fluorescence “Off-On-Off” probe. The limits of detection for Al3+ and F- were calculated from the titration curve and found to be 1.1 × 10-7 M and 1.47 × 10-6 M, respectively.

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Tetrahydroisoquinoline – Wikipedia,
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This invention relates to substituted heteroanilide compounds which are modulators, agonists or antagonists, of the CCR5 receptior. In addition, this invention relates to the treatment and prevention of disease states mediatd by CCR5.

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Chemical Research Letters, May 2021. name: 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.57196-62-0, Name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, molecular formula is C10H14ClNO. In a Article,once mentioned of 57196-62-0

Three transition-metal coordination polymers with azide and/or carboxylate bridges have been synthesized from 4-(3-pyridyl)benzoic acid (4,3-Hpybz) and 4-(4-pyridyl)benzoic acid (4,4-Hpybz) and characterized by X-ray crystallography and magnetic measurements. Compound 1, [Cu(4,3-pybz)(N3)] n, consists of 2D coordination networks in which the uniform chains with (mu-EO-N3)(mu-COO) double bridges are cross-linked by the 4,3-pybz ligands. Compound 2, [Cu2(4,4-pybz)3(N 3)]n?3nH2O, consists of 2-fold interpenetrated 3D coordination networks with the alpha-Po topology, in which the six-connected dinuclear motifs with mixed (mu-EO-N3)(mu-COO) 2 (EO = end-on) triple bridges are linked by the 4,4-pybz spacers. Compound 3, [Mn(4,4-pybz)(N3)(H2O)2] n, contains 2D manganese(II) coordination networks in which the chains with single mu-EE-N3 bridges (EE = end-to-end) are interlinked by the 4,4-pybz ligands, and the structure also features a 2D hydrogen-bonded network in which MnII ions are linked by double triatomic bridges, (mu-EE-N3)(O-H???N) and (O-H???O)2. Magnetic studies indicated that the mixed azide and carboxylate bridges in 1 and 2 induce ferromagnetic coupling between CuII ions and that 3 features antiferromagnetic coupling through the EE-azide bridge. In addition, compound 1 exhibits antiferromagnetic ordering below 6.2 K and behaves as a field-induced metamagnet. A magnetostructural survey indicates a general trend that the ferromagnetic coupling through the mixed bridges decreases as the Cu-N-Cu angle increases.

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Research speed reading in 2021. An article , which mentions Quality Control of 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, molecular formula is C10H14ClNO. The compound – 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride played an important role in people’s production and life., Quality Control of 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Four novel three-dimensional (3D) 4d-4f heterometal-organic compounds, [LnCd2(Pbc)4(Meimdc)(H2O)]·3H2O (Ln = Eu, 1a; Tb, 1b; Sm, 1c; Dy, 1d) (HPbc = 4-(4-pyridinyl)benzoic acid; H3Meimdc = 2-methyl-1H-4,5-imidazole-dicarboxylic acid), have been successfully prepared by a hydrothermal method. All the compounds are isostructural and show three-dimensional microporous pillar-layered structures with uncoordinated carboxylate sites hung in the channels. Compound 1a possesses excellent chemical stability. The luminescent investigations show that compounds 1a, 1b, 1c, and 1d display the characteristic emission bands of Ln3+ ions. Compound 1a exhibits a good potential as a luminescent sensor material for multi-responsive Ag+, Cu2+, Zn+, Co2+, and Ni2+ cations and some organic amines. Interestingly, 1a can capture Ag+, Cu2+, Zn+, Co2+, and Ni2+ cations and shows cation-dependent colorimetric response, which indicates the potential for naked sensing.

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We have been exploring the potential of 5-HT2B antagonists as a therapy for chronic heart failure. To assess the potential of this therapeutic approach, we sought compounds possessing the following attributes: (a) potent and selective antagonism of the 5-HT2B receptor, (b) low impact of serum proteins on potency, and (c) desirable pharmacokinetic properties. This Letter describes our investigation of a biphenyl benzimidazole class of compounds that resulted in 5-HT2B antagonists possessing the above attributes. Improving potency in a human serum albumin shift assay proved to be the most significant SAR discovery.

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Tetrahydroisoquinoline – Wikipedia,
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The exploitation of new titanium-based coordination polymers (Ti CPs) with high crystallinity is difficult but highly desirable for their potential applications in photocatalysis. Herein, a cluster-cooperative assemble strategy is developed to synthesize Ti CPs. By utilizing various bifunctional ligands containing carboxylate acids and N-donor groups, we successfully assembled the zero-dimensional (0D) [(Ti3O)(iPrO)8]2+ or [(Ti4O2)(iPrO)6]6+ clusters into one-dimensional (1D) tube-, ribbon-, or helical chain-shape architectures, two-dimensional (2D) layered structures, and a rare parallel 2D?three-dimensional (3D) polycatenation framework with various copper iodide dopants, including rhombus- or wing-shaped Cu2I2 and tetrahedron- or ladder-shaped Cu4I4. The as-synthesized compounds display strong absorption in the visible region with narrow band gaps ranging from 1.70 to 2.72 eV and exhibit good photocatalytic activities in the degradation of organic pollutants.

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Tetrahydroisoquinoline – Wikipedia,
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The present invention relates to novel crystalline forms of an inhibitor of Factor Xa, processes for its preparation, compositions comprising it, and its therapeutic use.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem