Category: 57399-11-8

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and Antiplasmodial Activity of New Indolone N-Oxide Derivatives, published in 2010-01-28, which mentions a compound: 57399-11-8, mainly applied to indolone oxide preparation antiplasmodial activity, Reference of 4-Chloro-4′-ethynyl-1,1′-biphenyl.

A series of 66 new indolone-N-oxide derivatives, e.g. I, was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ and pyrimethamine cross-resistant (K1) strains of Plasmodium falciparum (P.f.), as well as for cytotoxic concentration (CC50) on MCF7 and KB human tumor cell lines. Compound II (5-methoxy-indolone-N-oxide analog) had the most potent antiplasmodial activity in vitro (<3 nM on FcB1 and = 1.7 nM on 3D7) with a very satisfactory selectivity index (CC50 MCF7/IC50 FcB1: 14623; CC50 KB/IC50 3D7: 198823). In in vivo experiments, compound I (dioxymethylene derivatives of the indolone-N-oxide) showed the best antiplasmodial activity against Plasmodium berghei, 62% inhibition of the parasitemia at 30 mg/kg/day. The article 《Synthesis and Antiplasmodial Activity of New Indolone N-Oxide Derivatives》 also mentions many details about this compound(57399-11-8)Reference of 4-Chloro-4′-ethynyl-1,1′-biphenyl, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Name: 4-Chloro-4′-ethynyl-1,1′-biphenyl. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Chloro-4′-ethynyl-1,1′-biphenyl, is researched, Molecular C14H9Cl, CAS is 57399-11-8, about Synthesis and Antiplasmodial Activity of New Indolone N-Oxide Derivatives. Author is Nepveu, Francoise; Kim, Sothea; Boyer, Jeremie; Chatriant, Olivier; Ibrahim, Hany; Reybier, Karine; Monje, Marie-Carmen; Chevalley, Severine; Perio, Pierre; Lajoie, Barbora H.; Bouajila, Jalloul; Deharo, Eric; Sauvain, Michel; Tahar, Rachida; Basco, Leonardo; Pantaleo, Antonella; Turini, Francesco; Arese, Paolo; Valentin, Alexis; Thompson, Eloise; Vivas, Livia; Petit, Serge; Nallet, Jean-Pierre.

A series of 66 new indolone-N-oxide derivatives, e.g. I, was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ and pyrimethamine cross-resistant (K1) strains of Plasmodium falciparum (P.f.), as well as for cytotoxic concentration (CC50) on MCF7 and KB human tumor cell lines. Compound II (5-methoxy-indolone-N-oxide analog) had the most potent antiplasmodial activity in vitro (<3 nM on FcB1 and = 1.7 nM on 3D7) with a very satisfactory selectivity index (CC50 MCF7/IC50 FcB1: 14623; CC50 KB/IC50 3D7: 198823). In in vivo experiments, compound I (dioxymethylene derivatives of the indolone-N-oxide) showed the best antiplasmodial activity against Plasmodium berghei, 62% inhibition of the parasitemia at 30 mg/kg/day. After consulting a lot of data, we found that this compound(57399-11-8)Name: 4-Chloro-4′-ethynyl-1,1′-biphenyl can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-Chloro-4′-ethynyl-1,1′-biphenyl(SMILESS: C#CC1=CC=C(C2=CC=C(Cl)C=C2)C=C1,cas:57399-11-8) is researched.Recommanded Product: 1452-77-3. The article 《Copper-Catalyzed and Proton-Directed Selective Hydroxymethylation of Alkynes with CO2》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:57399-11-8).

An intriguing strategy for copper-catalyzed hydroxymethylation of alkynes with CO2 and hydrosilane was developed. Switched on/off a proton source, for example, t-BuOH, direct hydroxymethylation and reductive hydroxymethylation could be triggered selectively, delivering a series of allylic alcs. and homobenzylic alcs., resp., with high levels of Z/E, regio- and enantioselectivity. Such a selective synthesis is attributed to the differences in response of vinylcopper intermediate to proton and CO2. The protonation of vinylcopper species is demonstrated to be prior to hydroxymethylation, thus allowing a diversion from direct alkyne hydroxymethylation to reductive hydroxymethylation in the presence of a suitable proton source.

Although many compounds look similar to this compound(57399-11-8)Application In Synthesis of 4-Chloro-4′-ethynyl-1,1′-biphenyl, numerous studies have shown that this compound(SMILES:C#CC1=CC=C(C2=CC=C(Cl)C=C2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

COA of Formula: C14H9Cl. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Chloro-4′-ethynyl-1,1′-biphenyl, is researched, Molecular C14H9Cl, CAS is 57399-11-8, about Chemodivergent Synthesis of One-Carbon-Extended Alcohols via Copper-Catalyzed Hydroxymethylation of Alkynes with Formic Acid. Author is Jin, Xin; Fu, Hong-Chen; Wang, Mei-Yan; Huang, Shouying; Wang, Yue; He, Liang-Nian; Ma, Xinbin.

Here an intriguing strategy for the chemodivergent copper-catalyzed hydroxymethylation of alkynes RCCR1 (R = Ph, cyclopropyl, thiophen-2-yl, etc.; R1 = Ph, H, 3-fluorophenyl, 2-fluorophenyl, etc.) and R2CCH [R2 = 4-(4-methylphenyl)phenyl, 4-(4-fluorophenyl)phenyl, 4-(thiophen-2-yl)phenyl, etc.] and 9-ethynylphenanthrene with formic acid and hydrosilane has been developed. By simply tuning the amount of formic acid and reaction temperature, distinct one-carbon-extended primary alcs., i.e., allylic alcs. (E)/(Z)-RCH=C(R1)CH2OH and β-branched alkyl alcs., (S)-R2CH(CH3)CH2OH and (S)-2-(phenanthren-9-yl)propan-1-ol were produced with high levels of Z/E-, regio-, and enantioselectivity.

Compounds in my other articles are similar to this one(4-Chloro-4′-ethynyl-1,1′-biphenyl)COA of Formula: C14H9Cl, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 57399-11-8, is researched, SMILESS is C#CC1=CC=C(C2=CC=C(Cl)C=C2)C=C1, Molecular C14H9ClJournal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called Synthesis and Antiplasmodial Activity of New Indolone N-Oxide Derivatives, Author is Nepveu, Francoise; Kim, Sothea; Boyer, Jeremie; Chatriant, Olivier; Ibrahim, Hany; Reybier, Karine; Monje, Marie-Carmen; Chevalley, Severine; Perio, Pierre; Lajoie, Barbora H.; Bouajila, Jalloul; Deharo, Eric; Sauvain, Michel; Tahar, Rachida; Basco, Leonardo; Pantaleo, Antonella; Turini, Francesco; Arese, Paolo; Valentin, Alexis; Thompson, Eloise; Vivas, Livia; Petit, Serge; Nallet, Jean-Pierre, the main research direction is indolone oxide preparation antiplasmodial activity.Computed Properties of C14H9Cl.

A series of 66 new indolone-N-oxide derivatives, e.g. I, was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ and pyrimethamine cross-resistant (K1) strains of Plasmodium falciparum (P.f.), as well as for cytotoxic concentration (CC50) on MCF7 and KB human tumor cell lines. Compound II (5-methoxy-indolone-N-oxide analog) had the most potent antiplasmodial activity in vitro (<3 nM on FcB1 and = 1.7 nM on 3D7) with a very satisfactory selectivity index (CC50 MCF7/IC50 FcB1: 14623; CC50 KB/IC50 3D7: 198823). In in vivo experiments, compound I (dioxymethylene derivatives of the indolone-N-oxide) showed the best antiplasmodial activity against Plasmodium berghei, 62% inhibition of the parasitemia at 30 mg/kg/day. Compounds in my other articles are similar to this one(4-Chloro-4'-ethynyl-1,1'-biphenyl)Computed Properties of C14H9Cl, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-Chloro-4′-ethynyl-1,1′-biphenyl, is researched, Molecular C14H9Cl, CAS is 57399-11-8, about Chemodivergent Synthesis of One-Carbon-Extended Alcohols via Copper-Catalyzed Hydroxymethylation of Alkynes with Formic Acid.Formula: C14H9Cl.

Here an intriguing strategy for the chemodivergent copper-catalyzed hydroxymethylation of alkynes RCCR1 (R = Ph, cyclopropyl, thiophen-2-yl, etc.; R1 = Ph, H, 3-fluorophenyl, 2-fluorophenyl, etc.) and R2CCH [R2 = 4-(4-methylphenyl)phenyl, 4-(4-fluorophenyl)phenyl, 4-(thiophen-2-yl)phenyl, etc.] and 9-ethynylphenanthrene with formic acid and hydrosilane has been developed. By simply tuning the amount of formic acid and reaction temperature, distinct one-carbon-extended primary alcs., i.e., allylic alcs. (E)/(Z)-RCH=C(R1)CH2OH and β-branched alkyl alcs., (S)-R2CH(CH3)CH2OH and (S)-2-(phenanthren-9-yl)propan-1-ol were produced with high levels of Z/E-, regio-, and enantioselectivity.

When you point to this article, it is believed that you are also very interested in this compound(57399-11-8)Formula: C14H9Cl and due to space limitations, I can only present the most important information.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: 4-Chloro-4′-ethynyl-1,1′-biphenyl. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-Chloro-4′-ethynyl-1,1′-biphenyl, is researched, Molecular C14H9Cl, CAS is 57399-11-8, about Discovery of a novel series of N-hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality. Author is Singh, Sarbjit; Goo, Ja-Il; Noh, Hyojin; Lee, Sung Jae; Kim, Myoung Woo; Park, Hyejun; Jalani, Hitesh B.; Lee, Kyeong; Kim, Chunsook; Kim, Won-Ki; Ju, Chung; Choi, Yongseok.

Astrocytes play a key role in brain homeostasis, protecting neurons against neurotoxic stimuli such as oxidative stress. Therefore, the neuroprotective therapeutics that enhance astrocytic functionality has been regarded as a promising strategy to reduce brain damage. We previously reported that ciclopirox, a well-known antifungal N-hydroxypyridone compound, protects astrocytes from oxidative stress by enhancing mitochondrial function. Using the N-hydroxypyridone scaffold, we have synthesized a series of cytoprotective derivatives Mitochondrial activity assay showed that N-hydroxypyridone derivatives with biphenyl group have comparable to better protective effects than ciclopirox in astrocytes exposed to H2O2. N-hydroxypyridone derivatives, especially 11g, inhibited H2O2-induced deterioration of mitochondrial membrane potential and oxygen consumption rate, and significantly improved cell viability of astrocytes. The results indicate that the N-hydroxypyridone motif can provide a novel cytoprotective scaffold for astrocytes via enhancing mitochondrial functionality.

When you point to this article, it is believed that you are also very interested in this compound(57399-11-8)Recommanded Product: 4-Chloro-4′-ethynyl-1,1′-biphenyl and due to space limitations, I can only present the most important information.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: 57399-11-8. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-Chloro-4′-ethynyl-1,1′-biphenyl, is researched, Molecular C14H9Cl, CAS is 57399-11-8, about Discovery of a novel series of N-hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality. Author is Singh, Sarbjit; Goo, Ja-Il; Noh, Hyojin; Lee, Sung Jae; Kim, Myoung Woo; Park, Hyejun; Jalani, Hitesh B.; Lee, Kyeong; Kim, Chunsook; Kim, Won-Ki; Ju, Chung; Choi, Yongseok.

Astrocytes play a key role in brain homeostasis, protecting neurons against neurotoxic stimuli such as oxidative stress. Therefore, the neuroprotective therapeutics that enhance astrocytic functionality has been regarded as a promising strategy to reduce brain damage. We previously reported that ciclopirox, a well-known antifungal N-hydroxypyridone compound, protects astrocytes from oxidative stress by enhancing mitochondrial function. Using the N-hydroxypyridone scaffold, we have synthesized a series of cytoprotective derivatives Mitochondrial activity assay showed that N-hydroxypyridone derivatives with biphenyl group have comparable to better protective effects than ciclopirox in astrocytes exposed to H2O2. N-hydroxypyridone derivatives, especially 11g, inhibited H2O2-induced deterioration of mitochondrial membrane potential and oxygen consumption rate, and significantly improved cell viability of astrocytes. The results indicate that the N-hydroxypyridone motif can provide a novel cytoprotective scaffold for astrocytes via enhancing mitochondrial functionality.

As far as I know, this compound(57399-11-8)Recommanded Product: 57399-11-8 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jin, Xin; Fu, Hong-Chen; Wang, Mei-Yan; Huang, Shouying; Wang, Yue; He, Liang-Nian; Ma, Xinbin researched the compound: 4-Chloro-4′-ethynyl-1,1′-biphenyl( cas:57399-11-8 ).HPLC of Formula: 57399-11-8.They published the article 《Chemodivergent Synthesis of One-Carbon-Extended Alcohols via Copper-Catalyzed Hydroxymethylation of Alkynes with Formic Acid》 about this compound( cas:57399-11-8 ) in Organic Letters. Keywords: alc preparation regioselective diastereoselective enantioselective chemoslective green chem; alkyne formic acid hydroxymethylation copper catalyst. We’ll tell you more about this compound (cas:57399-11-8).

Here an intriguing strategy for the chemodivergent copper-catalyzed hydroxymethylation of alkynes RCCR1 (R = Ph, cyclopropyl, thiophen-2-yl, etc.; R1 = Ph, H, 3-fluorophenyl, 2-fluorophenyl, etc.) and R2CCH [R2 = 4-(4-methylphenyl)phenyl, 4-(4-fluorophenyl)phenyl, 4-(thiophen-2-yl)phenyl, etc.] and 9-ethynylphenanthrene with formic acid and hydrosilane has been developed. By simply tuning the amount of formic acid and reaction temperature, distinct one-carbon-extended primary alcs., i.e., allylic alcs. (E)/(Z)-RCH=C(R1)CH2OH and β-branched alkyl alcs., (S)-R2CH(CH3)CH2OH and (S)-2-(phenanthren-9-yl)propan-1-ol were produced with high levels of Z/E-, regio-, and enantioselectivity.

This literature about this compound(57399-11-8)HPLC of Formula: 57399-11-8has given us a lot of inspiration, and I hope that the research on this compound(4-Chloro-4′-ethynyl-1,1′-biphenyl) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Angewandte Chemie, International Edition called Copper-Catalyzed and Proton-Directed Selective Hydroxymethylation of Alkynes with CO2, Author is Wang, Mei-Yan; Jin, Xin; Wang, Xiaofei; Xia, Shumei; Wang, Yue; Huang, Shouying; Li, Ying; He, Liang-Nian; Ma, Xinbin, which mentions a compound: 57399-11-8, SMILESS is C#CC1=CC=C(C2=CC=C(Cl)C=C2)C=C1, Molecular C14H9Cl, COA of Formula: C14H9Cl.

An intriguing strategy for copper-catalyzed hydroxymethylation of alkynes with CO2 and hydrosilane was developed. Switched on/off a proton source, for example, t-BuOH, direct hydroxymethylation and reductive hydroxymethylation could be triggered selectively, delivering a series of allylic alcs. and homobenzylic alcs., resp., with high levels of Z/E, regio- and enantioselectivity. Such a selective synthesis is attributed to the differences in response of vinylcopper intermediate to proton and CO2. The protonation of vinylcopper species is demonstrated to be prior to hydroxymethylation, thus allowing a diversion from direct alkyne hydroxymethylation to reductive hydroxymethylation in the presence of a suitable proton source.

In addition to the literature in the link below, there is a lot of literature about this compound(4-Chloro-4′-ethynyl-1,1′-biphenyl)COA of Formula: C14H9Cl, illustrating the importance and wide applicability of this compound(57399-11-8).

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem