Category: 693-67-4

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 693-67-4, is researched, Molecular C11H23Br, about Developing design tools for introducing and tuning structural order in ionic liquids, the main research direction is dodecyl methyl alkylimidazolium bromide preparation thermal crystal structure mol.Recommanded Product: 693-67-4.

To investigate what is driving structural order in imidazolium-based ionic liquids (ILs) a series of asym. 1-dodecyl-2-methyl-3-alkylimidazolium bromides I [R = H, Me, n-Bu, etc.] was synthesized, fully characterized and their structures and properties compared with the analogous 1-dodecyl-3-alkylimidazolium as well as the 1,2,3-triazolium bromides. The aim was to examine the influence of the replacement of the most acidic 2-H proton on the imidazolium head group by methylation on the properties and structure of ILs. For all compounds, except for compounds with butyl- and hexyl-chains as well as the protonated species, mesophase formation was observed Obviously, the simple presence of long alkyl chains such as dodecyl (a design concept frequently put forward in the literature) was not sufficient to support mesophase formation alone. Rather, for the formation of a liquid crystalline phase, a balance between attractive van der Waals forces, hydrogen bonds, and electrostatic interactions was required. Data from temperature-dependent small-angle X-ray scattering (SAXS) and polarizing optical microscopy (POM) suggested three different cation conformations for the studied compounds I: cations with 0 ≤ n ≤ 4 exhibited a near-linear conformation; for 5 ≤ n ≤ 10 a V-shape is adopted, and for n = 11 or 12 a U-shape was found. It was demonstrated that the structural possibility for an interdigitation of the long chains is an influential factor for the formation of a mesophase.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Related Products of 693-67-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA. Author is Zhang, Dapeng; Atochina-Vasserman, Elena N.; Maurya, Devendra S.; Huang, Ning; Xiao, Qi; Ona, Nathan; Liu, Matthew; Shahnawaz, Hamna; Ni, Houping; Kim, Kyunghee; Billingsley, Margaret M.; Pochan, Darrin J.; Mitchell, Michael J.; Weissman, Drew; Percec, Virgil.

Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine. Both viral and synthetic vectors have been successfully employed for genetic delivery with recent examples being DNA, adenoviral, and mRNA-based Covid-19 vaccines. Viral vectors can be target specific and very efficient but can also mediate severe immune response, cell toxicity, and mutations. Four-component lipid nanoparticles (LNPs) containing ionizable lipids, phospholipids, cholesterol for mech. properties, and PEG-conjugated lipid for stability represent the current leading nonviral vectors for mRNA. However, the segregation of the neutral ionizable lipid as droplets in the core of the LNP, the “”PEG dilemma””, and the stability at only very low temperatures limit their efficiency. Here, we report the development of a one-component multifunctional ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA that exhibits high activity at a low concentration of ionizable amines organized in a sequence-defined arrangement. Six libraries containing 54 sequence-defined IAJDs were synthesized by an accelerated modular-orthogonal methodol. and coassembled with mRNA into dendrimersome nanoparticles (DNPs) by a simple injection method rather than by the complex microfluidic technol. often used for LNPs. Forty four (81%) showed activity in vitro and 31 (57%) in vivo. Some, exhibiting organ specificity, are stable at 5°C and demonstrated higher transfection efficiency than pos. control experiments in vitro and in vivo. Aside from practical applications, this proof of concept will help elucidate the mechanisms of packaging and release of mRNA from DNPs as a function of ionizable amine concentration, their sequence, and constitutional isomerism of IAJDs.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Quality Control of 1-Bromoundecane. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Probing the substitution pattern of indole-based scaffold reveals potent and selective sphingosine kinase 2 inhibitors. Author is Congdon, Molly; Fritzemeier, Russell G.; Kharel, Yugesh; Brown, Anne M.; Serbulea, Vlad; Bevan, David R.; Lynch, Kevin R.; Santos, Webster L..

Elevated levels of sphingosine 1-phosphate (S1P) and increased expression of sphingosine kinase isoforms (SphK1 and SphK2) have been implicated in a variety of disease states including cancer, inflammation, and autoimmunity. Selective inhibition of either SphK1 or SphK2 has been demonstrated to be effective in modulating S1P levels in animal models. Previously, authors reported a SphK2 naphthalene-based selective inhibitor, (R)-2-(3-(7-(pentyloxy)naphthalen-2-yl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide hydrochloride, which displays approx. 7-fold selectivity for hSphK2 over hSphK1 and has a SphK2 Ki value of 1.0μM. To improve SphK2 potency and selectivity, author’s designed, synthesized, and evaluated a series of indole-based compounds derived from (R)-2-(3-(7-(pentyloxy)naphthalen-2-yl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide hydrochloride. After investigating substitution patterns around the indole ring, author’s discovered that 1,5-disubstitution promoted optimal binding in the SphK2 substrate binding site and subsequent inhibition of enzymic activity. Author’s studies led to the identification of I (SphK2 Ki = 90 nM, >110 fold selective for SphK2 over SphK1). Mol. modeling studies revealed key nonpolar interactions with Val308, Phe548, His556, and Cys533 and hydrogen bonds with both Asp211 and Asp308 as responsible for the high SphK2 inhibition and selectivity.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Name: 1-Bromoundecane. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Liquid crystal and photoluminescent properties of a series of symmetrical 1,2-bis(4-alkoxybenzylidene)hydrazines bearing long-tails of hydrocarbon chain. Author is Al-Karawi, Ahmed Jasim M.; OmarAli, Al-Ameen Bariz; Awad, Adil A.; Doungmo, Giscard; Terraschke, Huayna.

In this work, 1,2-bis[4-(n-alkoxy)benzylidene]hydrazine (n-alkoxy: O(CH2)nH, n = 11-18 or 20), a sym. series of azines (linear compounds with rod-like shape structure), were synthesized using a very simple two-step procedure as a part of our continuing effort in evaluating hydrophobic 1,2-disubstituted hydrazine compounds as photoluminescent liquid crystalline materials. The first step of the synthesis involved the alkylation of the OH group of 4-hydroxybenzaldehyde in basic medium using the Williamson method to obtain 4-alkoxybenzaldehydes. While the second step included the condensation reaction of hydrazine hydrate and appropriately 4-alkoxybenzaldehydes compounds (mole ratio 1:2, resp.) in acidic medium under ambient conditions. The prepared compounds were characterised and their structures elucidated depending upon IR (IR), UV-visible (UV-Vis), NMR (1HNMR, 13CNMR, DEPT NMR, 2D 1H-1H-COSY and 2D 1H-13C- HSQC) and elemental anal. (CHN). Liquid crystalline behavior and photoluminescent properties were studied using polarised light optical microscopy (POM), fluorescence emissions (FE), differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD) techniques. The studies showed that all of these compounds were enantiotropic liquid crystalline materials exhibiting smectic (SmA and SmC) and nematic (droplet and thread) mesophases . The study also displayed that all of the prepared compounds were photoluminescent in the crystalline and liquid crystal states.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Application of 693-67-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Direct Trifluoromethoxylation without OCF3-Carrier through In Situ Generation of Fluorophosgene. Author is Saiter, Jeremy; Guerin, Thomas; Donnard, Morgan; Panossian, Armen; Hanquet, Gilles; Leroux, Frederic R..

The method represented the preparation of a range of trifluoromethoxylated structures R-OCF3 [R = undecanyl, (CH2)2Ph, 4-BrC6H4CH2, etc.] with no use of an intermediate trifluoromethoxylating reagent, but in situ construction and use of the F3CO anion as a salt, avoiding the presence of a useless side-product resulting from activation of an OCF3 carrier.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 693-67-4, is researched, SMILESS is CCCCCCCCCCCBr, Molecular C11H23BrJournal, Mendeleev Communications called Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer, Author is Vereshchagin, Anatoly N.; Frolov, Nikita A.; Konyuhova, Valeria Yu.; Hansford, Karl A.; Egorov, Mikhail P., the main research direction is oxybisphenylene bisoxy dialkylpyridinium dihalide preparation; antibacterial antifungal cytotoxicity hemolytic activity SAR.Related Products of 693-67-4.

Novel gemini (tail-head-spacer-head-tail) bis-quaternary ammonium compounds I [n = 7, 8, 9, etc.] with a 4,4′-oxydiphenol spacer between two pyridinium heads were synthesized and compared with commonly used antiseptics such as benzalkonium chloride and chlorhexidine gluconate. Analogs bearing C8H17, C9H19 and C10H21 aliphatic groups displayed potent broad spectrum in-vitro activity against five bacterial strains and two fungi, with min. inhibitory concentrations relatively independent of the counter ion.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Product Details of 693-67-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Charge Transportation and Chirality in Liquid Crystalline Helical Network Phases of Achiral BTBT-Derived Polycatenar Molecules.

First examples of multichain (polycatenar) compounds, based on the π-conjugated [1]benzothieno[3,2-b]benzothiophene unit (I, R = alkyl homologs) are designed, synthesized, and their soft self-assembly and charge carrier mobility are investigated. These compounds, terminated by the new fan-shaped 2-brominated 3,4,5-trialkoxybenzoate moiety, form bicontinuous cubic liquid crystalline (LC) phases with helical network structure over extremely wide temperature ranges (>200 K), including ambient temperature Compounds with short chains show an achiral cubic phase with the double network, which upon increasing the chain length, is at first replaced by a tetragonal 3D phase and then by a mirror symmetry is broken triple network cubic phase. In the networks, the capability of bypassing defects provides enhanced charge carrier mobility compared to imperfectly aligned columnar phases, and the charge transportation is non-dispersive, as only rarely observed for LC materials. At the transition to a semicrystalline helical network phase, the conductivity is further enhanced by almost one order of magnitude. In addition, a mirror symmetry broken isotropic liquid phase is formed beside the 3D phases, which upon chain elongation is removed and replaced by a hexagonal columnar LC phase.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and antibacterial activity of new tetrakisquaternary ammonium compounds based on pentaerythritol and 3-hydroxypyridine, published in 2021-03-31, which mentions a compound: 693-67-4, Name is 1-Bromoundecane, Molecular C11H23Br, COA of Formula: C11H23Br.

Tetrakisquaternary ammonium compounds based on pentaerythritol I (n = 7, 8, 9, 10, 11, 12) were synthesized for the first time. Bacteriostatic effect of the obtained compounds I was evaluated towards opportunistic gram-pos. Methicillin-resistant Staphylococcus aureus (strain ATCC 25923), gram-neg. Escherichia coli (ATCC 25922), and Pseudomonas aeruginosa (ATCC 27853). The activity of reported salts I was evaluated competitively with that of known antiseptics, Octenidine Dihydrochloride and Chlorhexidine Digluconate. The effect of length of the alkyl substituent in the salts I on their biol. activity was established. These new compounds I are based on available pentaerythritol and 3-hydroxypyridine.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Bromoundecane(SMILESS: CCCCCCCCCCCBr,cas:693-67-4) is researched.Recommanded Product: 15227-42-6. The article 《Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer》 in relation to this compound, is published in Mendeleev Communications. Let’s take a look at the latest research on this compound (cas:693-67-4).

Novel gemini (tail-head-spacer-head-tail) bis-quaternary ammonium compounds I [n = 7, 8, 9, etc.] with a 4,4′-oxydiphenol spacer between two pyridinium heads were synthesized and compared with commonly used antiseptics such as benzalkonium chloride and chlorhexidine gluconate. Analogs bearing C8H17, C9H19 and C10H21 aliphatic groups displayed potent broad spectrum in-vitro activity against five bacterial strains and two fungi, with min. inhibitory concentrations relatively independent of the counter ion.

There are many compounds similar to this compound(693-67-4)Reference of 1-Bromoundecane. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Bromoundecane( cas:693-67-4 ) is researched.Name: 1-Bromoundecane.Su, Yingyu; Chen, Guoshun; Cai, Yu; Gao, Bolan; Zhi, Xijun; Chang, Fengjiang published the article 《Effects of Broussonetia papyrifera-fermented feed on the growth performfermentedance and muscle quality of Hu sheep》 about this compound( cas:693-67-4 ) in Canadian Journal of Animal Science. Keywords: Broussonetia papyrifera fermentation feed muscle quality Hu sheep. Let’s learn more about this compound (cas:693-67-4).

This study aims to determine the effect of adding different proportions of Broussonetia papyrifera (BP)-fermented feed on Hu sheep. A total of 40 male Hu sheep (weighting 20.6 ± 2.20 kg) were collected and then divided into group I, II, III, and IV, with 0%, 5%, 10%, and 15% of BP-fermented feed to based diet, resp. After the trial period of 10 and 50 d, the sheep were slaughtered by conventional methods for the chem. analyses. It showed that adding 10% fermented feed could significantly increase the growth performance of the Hu sheep. Adding the fermented feed can improve the protein level, main flavor amino acid content, and fatty acid in the muscle. Based on the headspace solid-phase microextraction and gas chromatog. – mass spectrometry methods, a total of 125, 120, 119, and 117 kinds of volatile compounds were identified in group I, II, III, and IV, among which the relative content of the acid compound, ester compound, ketone compound, and aldehydes in group II, III, and IV were higher than that in control group, resp. Addition of BP-fermented feed could significantly improve growth performance and meat quality of Hu sheep.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem