Category: 693-67-4

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Bromoundecane( cas:693-67-4 ) is researched.Electric Literature of C11H23Br.Zhang, Dapeng; Atochina-Vasserman, Elena N.; Maurya, Devendra S.; Huang, Ning; Xiao, Qi; Ona, Nathan; Liu, Matthew; Shahnawaz, Hamna; Ni, Houping; Kim, Kyunghee; Billingsley, Margaret M.; Pochan, Darrin J.; Mitchell, Michael J.; Weissman, Drew; Percec, Virgil published the article 《One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA》 about this compound( cas:693-67-4 ) in Journal of the American Chemical Society. Keywords: ionizable amphiphilic Janus dendrimer delivery system mRNA. Let’s learn more about this compound (cas:693-67-4).

Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine. Both viral and synthetic vectors have been successfully employed for genetic delivery with recent examples being DNA, adenoviral, and mRNA-based Covid-19 vaccines. Viral vectors can be target specific and very efficient but can also mediate severe immune response, cell toxicity, and mutations. Four-component lipid nanoparticles (LNPs) containing ionizable lipids, phospholipids, cholesterol for mech. properties, and PEG-conjugated lipid for stability represent the current leading nonviral vectors for mRNA. However, the segregation of the neutral ionizable lipid as droplets in the core of the LNP, the “”PEG dilemma””, and the stability at only very low temperatures limit their efficiency. Here, we report the development of a one-component multifunctional ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA that exhibits high activity at a low concentration of ionizable amines organized in a sequence-defined arrangement. Six libraries containing 54 sequence-defined IAJDs were synthesized by an accelerated modular-orthogonal methodol. and coassembled with mRNA into dendrimersome nanoparticles (DNPs) by a simple injection method rather than by the complex microfluidic technol. often used for LNPs. Forty four (81%) showed activity in vitro and 31 (57%) in vivo. Some, exhibiting organ specificity, are stable at 5°C and demonstrated higher transfection efficiency than pos. control experiments in vitro and in vivo. Aside from practical applications, this proof of concept will help elucidate the mechanisms of packaging and release of mRNA from DNPs as a function of ionizable amine concentration, their sequence, and constitutional isomerism of IAJDs.

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Tetrahydroisoquinoline – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Monodisperse micelles composed of poly(ethylene glycol) attached surfactants: platonic nature in a macromolecular aggregate, the main research direction is calixarene monodispersity platonic micelle.Quality Control of 1-Bromoundecane.

Among the many studies on micelles, dating back more than 100 years, we first found a series of monodisperse micelles: spherical micelles made from calix[4]arene surfactants exhibited monodispersity in aggregation number (Nagg) with values of 4, 6, 8, 12, and 20. We named these Platonic micelles because these values coincided with the face numbers of the Platonic solids. The preferred Nagg values were explained in relation to the math. Tammes problem: how to obtain the best coverage of a sphere surface with multiple identical circles. In this paper, we synthesized poly(ethylene glycol)-attached surfactants and carried out small-angle X-ray scattering (SAXS) and anal. ultracentrifugation (AUC) to determine the Nagg. We found that these polymeric surfactants also formed monodispersed micelles and Nagg discontinuously increased from 20 to 24, and then 32 with increasing the alkyl carbon numbers from 9 to 11 continuously. The determined Nagg was greater than 20 and the Platonic solid numbers We assumed that the preferred Nagg values could be explained in relation to the Tammes problem as well.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Viscosity of liquid bromoalkanes at ambient pressure from 253.15 to 423.15 K: New experimental data and their free volume theory-based interpretation, published in 2020-11-01, which mentions a compound: 693-67-4, Name is 1-Bromoundecane, Molecular C11H23Br, HPLC of Formula: 693-67-4.

This work reports new exptl. data for the viscosity of 1-bromopenthane (within the temperature range (253.15-298.15) K), 1-bromohexane ((263.15-293.15) K), 1-bromoheptane ((263.15-298.15) K), 1-bromooctane ((253.15-293.15) K), 1-bromononane ((253.15-413.15) K), 1-bromodecane ((253.15-423.15) K), 1-bromoundecane ((283.15-423.15) K), 1-bromododecane ((273.15-293.15) K), and 1-bromohexadecane ((298.15-423.15) K). Considering them in combination with previously known data for these substances, it is shown that the viscosity of this series of 1-bromoalkanes accurately satisfies the Bingham-Coombs model based on the free volume approach. The quant. connection of the excluded volume with the van der Waals volume and the packing fraction is revealed.

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Tetrahydroisoquinoline – Wikipedia,
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COA of Formula: C11H23Br. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Multiresponse Shape-Memory Nanocomposite with a Reversible Cycle for Powerful Artificial Muscles. Author is Chen, Chi; Liu, Yangyuanchen; He, Ximin; Li, Hua; Chen, Yujie; Wei, Ying; Zhao, Yusen; Ma, Yanfei; Chen, Zhen; Zheng, Xu; Liu, Hezhou.

In the field of bionic soft robots and microrobots, artificial muscle materials have exhibited unique potential for cutting-edge applications. However, current mainstream thermal-responsive artificial muscles based on semicrystalline polymers (SCPs), despite their excellent phys. properties, suffer from the limitation of environmental stimuli in practice, while their photodriven counterparts adopting liquid crystal elastomers (LCEs) lack ductility. Herein, a novel multifunctional programmable artificial muscle with a unique patch-sewing structure formed by π-π stacking between azobenzene groups was designed, which combined the advantages of SCPs and LCEs. The nanocomposite demonstrated a unique combination between artificial muscle performance (46.5 times the energy d. and 26.6 times the power d. of human skeletal muscles) and programmability (274.84% strain and 100% shape-memory recovery rate within 1 s). Meanwhile, coupling the photoisomerization of azobenzene and the photothermal conversion of gold nanorods, the cycle of deformation triggered by UV light and restoring by IR light could be accomplished rapidly within 30 s. A COMSOL Multiphysics model was established and the corresponding finite element anal. verified the photoactuation and captured the general principle of light initiation in elastomers. These demonstrate that the multifunctional programmable elastomer is promising for artificial muscle applications, especially for photoinduced actuation.

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Tetrahydroisoquinoline – Wikipedia,
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Zuma, Nonkululeko H.; Smit, Frans J.; Seldon, Ronnett; Aucamp, Janine; Jordaan, Audrey; Warner, Digby F.; N’Da, David D. published the article 《Single-step synthesis and in vitro anti-mycobacterial activity of novel nitrofurantoin analogues》. Keywords: nitrofurantoin preparation antimycobacterial antitumor human drug toxicity; Analogues; Drug resistance; Nitrofurans; Nitrofurantoin; Nitroreductase; Tuberculosis.They researched the compound: 1-Bromoundecane( cas:693-67-4 ).Quality Control of 1-Bromoundecane. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:693-67-4) here.

To improve TB efficacy of nitrofurantoin (NFT), a series of NFT analogs I [R = Me, Et, Bn, etc.] was synthesized and evaluated in vitro for anti-mycobacterial activity against the laboratory strain, Mtb H37Rv and for potential cytotoxicity using human embryonic kidney (HEK-293) and Chinese hamster ovarian (CHO) cells. The NFT analogs showed good safety profiles, enhanced anti-mycobacterial potency, improved lipophilicity, as well as reduced protein binding affinity. Analog I [R = n-Bu] which contains an eight carbon aliphatic chain was the most active, equipotent to isoniazid (INH), a major front-line agent, with MIC90 = 0.5μM, 30-fold more potency than the parent drug, nitrofurantoin (MIC90 = 15μM), and 100-fold more selective towards mycobacteria. Therefore, compound I [R = n-Bu] was identified as a validated hit for further investigation in the urgent search for new, safe and affordable TB drugs.

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Tetrahydroisoquinoline – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Molecular Liquids called Coumarin substituted symmetric diaminopyridine molecules: Synthesis, mesomorphic characterizations and DFT studies, Author is Mohammad, AbdulKarim-Talaq; Al-Mohammed, Mohammad Hameed; Srinivasa, H. T.; Ameen, Wissam Ahmed, which mentions a compound: 693-67-4, SMILESS is CCCCCCCCCCCBr, Molecular C11H23Br, SDS of cas: 693-67-4.

Synthesis and characterization of 2,6-diaminopyridine bearing sym. substituted coumarins I [R = n-pentyl, n-octyl, n-nonanyl, etc.] from a lateral side of the mols. was reported. All the mols. I were characterized by standard spectroscopic methods such as IR spectroscopy and NMR spectroscopy techniques. Mesomorphic properties were evaluated by the differential scanning calorimetry and the polarized optical microscope. The measurements showed that the lower members did not favor liquid crystal formation, while higher members were exhibiting liquid crystalline, namely nematic mesophase. The DFT computations manifest the nature of liquid crystal geometrical aspects.

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Tetrahydroisoquinoline – Wikipedia,
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Li, Jie; Li, Xiang; Yuan, Yan; Wang, Qi; Xie, Lisi; Dai, Yunlu; Wang, Wenjun; Li, Lin; Lu, Xiaomei; Fan, Quli; Huang, Wei published the article 《Efficient Polysulfide-Based Nanotheranostics for Triple-Negative Breast Cancer: Ratiometric Photoacoustics Monitored Tumor Microenvironment-Initiated H2S Therapy》. Keywords: polysulfide nanotheranostic breast cancer photoacoustic tumor microenvironment hydrogen sulfide; hydrogen sulfide; polysulfide; ratiometric photoacoustics; theranostics; triple-negative breast cancer.They researched the compound: 1-Bromoundecane( cas:693-67-4 ).Application of 693-67-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:693-67-4) here.

The incidence of triple-neg. breast cancer (TNBC) is difficult to predict, and TNBC has a high mortality rate among women worldwide. A theranostics approach is developed for TNBC with ratiometric photoacoustic monitored thiol-initiated hydrogen sulfide (H2S) therapy. The ratiometric photoacoustic (PA) probe (CY) with a thiol-initiated H2S donor (PSD) to form a nanosystem (CY-PSD nanoparticles) is integrated. In this theranostics approach, H2S generated from PSD is sensed by CY based on ratiometric PA signals, which simultaneously pinpoints the tumor region. Addnl., H2S is cytotoxic toward TNBC cells (MDA-MB 231), showing a tumor inhibition rate of 63%. To further verify its pharmacol. mechanism, proteomics anal. was performed on tumors treated with CY-PSD nanoparticles. Cells are killed by the significant mitochondrial dysfunction via suppressed energy supply and apoptosis initiation. Besides, the observed inhibition of oxidative stress also generates the cytotoxicity. Significant Kyoto Encyclopedia of Genes Genomes pathways related to TNBC are inhibited. This H2S theranostics approach updates the current anticancer therapies which brings promise for women suffering malignant breast cancer.

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Tetrahydroisoquinoline – Wikipedia,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer, published in 2020-07-31, which mentions a compound: 693-67-4, mainly applied to quaternary ammonium compound terphenyl spacer preparation SAR; antibacterial antifungal cytotoxicity human, Related Products of 693-67-4.

Bis-quaternary ammonium compounds I·2 Br- [R = H(CH2)n; n = 7, 8, 9, 10, 11] with a p-terphenyl spacer between two pyridinium heads were synthesized. I·2 Br- (n = 8) was superior to the known benzalkonium chloride, miramistin and chlorhexidine bisgluconate in its MIC values against five pathogenic bacteria.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Bromoundecane(SMILESS: CCCCCCCCCCCBr,cas:693-67-4) is researched.Related Products of 693-67-4. The article 《Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease》 in relation to this compound, is published in ACS Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:693-67-4).

The synthesis of series of lipophilic phenothiazine analogs I (n = 4, 5, 6, 8) that potently inhibit ferroptosis was reported in the present study. The most promising compounds I exhibited an improved protection compared to the parent phenothiazine against erastin- and RSL3-induced ferroptotic cell death. These analogs have equivalent or better potency than ferrostatin-1 (Fer-1) and liproxstatin-1 (Lip-1), which are among the most potent inhibitors of this regulated cell death described so far. They represent novel lead compounds with therapeutic potential in relevant ferroptosis-driven disease models such as FRDA.

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Product Details of 693-67-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about 4-Carboalkoxylated Polyvalerolactones from Malic Acid: Tough and Degradable Polyesters. Author is Fahnhorst, Grant W.; De Hoe, Guilhem X.; Hillmyer, Marc A.; Hoye, Thomas R..

Eight 4-carboalkoxyvalerolactones (CRVLs), varying in the composition of their alkyl (R) side chains, were synthesized from malic acid and subjected to ring-opening transesterification polymerization (ROTEP) using di-Ph phosphate [DPP, (PhO)2PO2H] as a catalyst. Each CRVL produced a semicrystalline poly(4-carboalkoxyvalerolactone) (PCRVL), and the nature of the R group impacted the thermal transitions of these polyesters. Bulk polymerizations at 70°C allowed for preparation of high molar mass samples that contained small amounts of branching, as evidenced by 1H NMR spectroscopy, MALDI spectrometry, size-exclusion chromatog., and eliminative degradation Tensile testing of these lightly branched, high molar mass samples revealed that these polyesters are tough (tensile toughness values up to 88 ± 33 MJ•m-3) and have Young’s moduli (E) up to 186 ± 13 MPa. The acid- and base-catalyzed hydrolytic degradation of the PCRVLs was quant. monitored using total organic carbon anal., and effect of the alkyl chain length on PCRVL hydrolysis rate was determined Finally, the Me ester variant of these malic acid-derived thermoplastics is known to be chem. recyclable.

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Tetrahydroisoquinoline – Wikipedia,
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