Category: 75416-50-1

The important role of 75416-50-1

With the complex challenges of chemical substances, we look forward to future research findings about 8-Chloro-1,2,3,4-tetrahydroisoquinoline

Name is 8-Chloro-1,2,3,4-tetrahydroisoquinoline, as a common heterocyclic compound, it belongs to tetrahydroisoquinoline compound, and cas is 75416-50-1, its synthesis route is as follows.,75416-50-1

A mixture of 8-chloro-1,2,3,4-tetrahydroisoquinoline (4.5 g, 22.0 mmol), 3-trifluoromethylbenzaldehyde (3.25 mL, 24.3 mmol), sodium acetate (1.81 g, 22.0 mmol), and acetic acid (0.63 mL, 11.0 mmol) in ethanol was stirred for 1 hour. Sodium triacetoxyborohydride (5.60 g, 26.5 mmol) was added a little at a time over a period of 30 min, and the mixture was then stirred for 15 hours. The reaction solution was diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was then distilled off at reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate=10:1), the resulting oily substance was dissolved in isopropyl alcohol (30 mL), and 4 N hydrogen chloride/ethyl acetate (5 mL) was added. The precipitated crystals were filtered off to give 5.89 g of the titled compound (yield 74%). Melting point: 217-218 C.1H-NMR (DMSO-d6) delta: 3.00-3.40 (4H, m), 4.20-4.40 (2H, m), 4.50-4.80 (2H, m), 7.25 (1H, d, J=7.5 Hz), 7.32 (1H, d, J=7.2 Hz), 7.38 (1H, t, J=7.2 Hz), 7.74 (1H, t, J=7.5 Hz), 7.80-7.90 (1H, m), 7.90-8.00 (1H, m), 8.10 (1H, s), 11.24 (1H, br s).

With the complex challenges of chemical substances, we look forward to future research findings about 8-Chloro-1,2,3,4-tetrahydroisoquinoline

Reference£º
Patent; Takeda Pharmaceutical Company Limited; US2010/41891; (2010); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Some tips on 75416-50-1

75416-50-1 8-Chloro-1,2,3,4-tetrahydroisoquinoline 12595071, atetrahydroisoquinoline compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75416-50-1,8-Chloro-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,75416-50-1

General procedure: A mixture of alkylating agent (1equiv), appropriate amine (1.1equiv) K2CO3 (1.1equiv), and KI (catalytic) in DME or CH3CN (50mL) was placed in a round bottomed flask with a stirrer was heated to reflux on a heating plate for 24-28 h. The reaction was monitored by TLC for product formation. After reaction was complete, the resulting crude mixture was directly purified on silica gel by flash chromatography (gradient up to 70% EtOAc in hexanes) to afford the final compounds. The free base where necessary, was converted to the HCl or HBr salt and crystallized out of a mixture of MeOH-Et2O.

75416-50-1 8-Chloro-1,2,3,4-tetrahydroisoquinoline 12595071, atetrahydroisoquinoline compound, is more and more widely used in various fields.

Reference£º
Article; Ofori, Edward; Zhu, Xue Y.; Etukala, Jagan R.; Bricker, Barbara A.; Ablordeppey, Seth Y.; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 5730 – 5740;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Brief introduction of 75416-50-1

The synthetic route of 75416-50-1 has been constantly updated, and we look forward to future research findings.

75416-50-1, 8-Chloro-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,75416-50-1

A mixture of 8-chloro-1,2,3,4-tetrahydroisoquinoline (4.5 g, 22.0 mmol), 3-trifluoromethylbenzaldehyde (3.25 mL, 24.3 mmol), sodium acetate (1.81 g, 22.0 mmol), and acetic acid (0.63 mL, 11.0 mmol) in ethanol was stirred for 1 hour. Sodium triacetoxyborohydride (5.60 g, 26.5 mmol) was added a little at a time over a period of 30 min, and the mixture was then stirred for 15 hours. The reaction solution was diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was then distilled off at reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate=10:1), the resulting oily substance was dissolved in isopropyl alcohol (30 mL), and 4 N hydrogen chloride/ethyl acetate (5 mL) was added. The precipitated crystals were filtered off to give 5.89 g of the titled compound (yield 74%). Melting point: 217-218 C.1H-NMR (DMSO-d6) delta: 3.00-3.40 (4H, m), 4.20-4.40 (2H, m), 4.50-4.80 (2H, m), 7.25 (1H, d, J=7.5 Hz), 7.32 (1H, d, J=7.2 Hz), 7.38 (1H, t, J=7.2 Hz), 7.74 (1H, t, J=7.5 Hz), 7.80-7.90 (1H, m), 7.90-8.00 (1H, m), 8.10 (1H, s), 11.24 (1H, br s).

The synthetic route of 75416-50-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; US2010/41891; (2010); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Downstream synthetic route of 75416-50-1

As the paragraph descriping shows that 75416-50-1 is playing an increasingly important role.

75416-50-1, 8-Chloro-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,75416-50-1

General procedure: A mixture of alkylating agent (1equiv), appropriate amine (1.1equiv) K2CO3 (1.1equiv), and KI (catalytic) in DME or CH3CN (50mL) was placed in a round bottomed flask with a stirrer was heated to reflux on a heating plate for 24-28 h. The reaction was monitored by TLC for product formation. After reaction was complete, the resulting crude mixture was directly purified on silica gel by flash chromatography (gradient up to 70% EtOAc in hexanes) to afford the final compounds. The free base where necessary, was converted to the HCl or HBr salt and crystallized out of a mixture of MeOH-Et2O.

As the paragraph descriping shows that 75416-50-1 is playing an increasingly important role.

Reference£º
Article; Ofori, Edward; Zhu, Xue Y.; Etukala, Jagan R.; Bricker, Barbara A.; Ablordeppey, Seth Y.; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 5730 – 5740;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Introduction of a new synthetic route about 8-Chloro-1,2,3,4-tetrahydroisoquinoline

With the rapid development of chemical substances, we look forward to future research findings about 75416-50-1

8-Chloro-1,2,3,4-tetrahydroisoquinoline, cas is 75416-50-1, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.

General procedure: A mixture of alkylating agent (1equiv), appropriate amine (1.1equiv) K2CO3 (1.1equiv), and KI (catalytic) in DME or CH3CN (50mL) was placed in a round bottomed flask with a stirrer was heated to reflux on a heating plate for 24-28 h. The reaction was monitored by TLC for product formation. After reaction was complete, the resulting crude mixture was directly purified on silica gel by flash chromatography (gradient up to 70% EtOAc in hexanes) to afford the final compounds. The free base where necessary, was converted to the HCl or HBr salt and crystallized out of a mixture of MeOH-Et2O., 75416-50-1

With the rapid development of chemical substances, we look forward to future research findings about 75416-50-1

Reference£º
Article; Ofori, Edward; Zhu, Xue Y.; Etukala, Jagan R.; Bricker, Barbara A.; Ablordeppey, Seth Y.; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 5730 – 5740;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Introduction of a new synthetic route about 75416-50-1

With the rapid development of chemical substances, we look forward to future research findings about 75416-50-1

8-Chloro-1,2,3,4-tetrahydroisoquinoline, cas is 75416-50-1, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.

General procedure: A mixture of alkylating agent (1equiv), appropriate amine (1.1equiv) K2CO3 (1.1equiv), and KI (catalytic) in DME or CH3CN (50mL) was placed in a round bottomed flask with a stirrer was heated to reflux on a heating plate for 24-28 h. The reaction was monitored by TLC for product formation. After reaction was complete, the resulting crude mixture was directly purified on silica gel by flash chromatography (gradient up to 70% EtOAc in hexanes) to afford the final compounds. The free base where necessary, was converted to the HCl or HBr salt and crystallized out of a mixture of MeOH-Et2O.

With the rapid development of chemical substances, we look forward to future research findings about 75416-50-1

Reference£º
Article; Ofori, Edward; Zhu, Xue Y.; Etukala, Jagan R.; Bricker, Barbara A.; Ablordeppey, Seth Y.; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 5730 – 5740;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem