Category: 75416-51-2

8-Bromo-1,2,3,4-tetrahydroisoquinoline, cas is 75416-51-2, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.

75416-51-2, 8-Bromo-1,2,3,4-tetrahydroisoquinoline 14.1 (200 mg, 0.804 mmol) was suspended in tetrahydrofuran (4 ml) and saturated sodium bicarbonate (2 ml) then di-t-butyl dicarbonate (263 mg, 1.21 mmol) was added as a solution in THF (2 ml) and the mixture was stirred atRT for 42 h. The reaction mixture was poured into water and extracted three times with ethyl acetate. The organic extract was dried over sodium sulfate, filtered and evaporated. The residue was purified via flash silica chromatography (heptane I DCM 0-80percent) to provide compound 14.2 (200 mg, 80percent) as a colourless oil. 1H NMR (ODd3, 400 MHz) O 1.30 (5, 9H), 2.82 (m, 2H), 3.63 (m, 2H), 4.60 (m, 2H), 7.05 (m, 2H), 7.39 (d, 1H). UPLC-MS (shortbasic) rt 1.01 (255, 257 [M-tBu+H]), 96percent pure.

With the rapid development of chemical substances, we look forward to future research findings about 8-Bromo-1,2,3,4-tetrahydroisoquinoline

Reference£º
Patent; THE UNIVERSITY OF SHEFFIELD; RICHARDS, Gareth; SKERRY, Timothy, M.; HARRITY, Joseph, P.A.; ZIRIMWABAGABO, Jean-Olivier; TOZER, Matthew, J.; GIBSON, Karl, Richard; PORTER, Roderick, Alan; BLANEY, Paul, Matthew; GLOSSOP, Paul, Alan; (369 pag.)WO2018/211275; (2018); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

As a common heterocyclic compound, it belongs to tetrahydroisoquinoline compound, name is 8-Bromo-1,2,3,4-tetrahydroisoquinoline, and cas is 75416-51-2, its synthesis route is as follows.

(a) 8-bromo-l,2,3,4-tetrahydroisoquinoline (64 mg, 0.3 mmol) was dissolved in acetonitrile, K2C03(166 mg, 1.2 mmol) and ethyl 2-bromoacetate (40 mu^, 0.36 mmol) were added. The mixture was stirred at r.t. over night. The solvent was evaporated off, and the residue was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. Purification through flash chromatography on silica gel eluted with 30percent ethyl acetate in hexane gave intermediate ethyl 2-(8-(2-chloro-4- methoxyphenyl)-3,4-dihydroisoquinolin-2(lH)-yl)acetate 73 mg as a brown oil, yield: 86.8percent. LC/MS: (ESI) [M+H]+= 299.2

75416-51-2, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,75416-51-2 ,8-Bromo-1,2,3,4-tetrahydroisoquinoline, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; UNIVERSITY OF WASHINGTON; FAN, Erkang; ZHANG, Zhongsheng; HUANG, Wenlin; BUCKNER, Frederick S.; (180 pag.)WO2018/237349; (2018); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

75416-51-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75416-51-2,8-Bromo-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.

A solution of 8-bromo-dihydroisoquinoline (300 mg, 1.42 mmol) in CH2Ch (14 mL) was cooled to 0 ¡ãC and zeta’RhobetaNuEpsilon (370 mg, 2.8 mmol) and CbzCl (480 mg, 2.8 mmol) were added. The reaction was stirred at room temperature forl6 h. The reaction was diluted with CH2CI2 (10 mL) and poured into water (20 mL). The layers were separated and the aqueous layer was extracted with CH2CI2 (3 x 20 mL). The combined organic layers were dried (Na2S04) and concentrated under reduced pressure. The crude mixture was purified via flash column chromatography eluting with EtOAc:hexanes (5:95) to give 401 mg (83percent) of compound KTL-02-108 as a clear oil: lH NMR (400 MHz) delta 7.44 – 7.29 (comp, 6 H), 7.11 – 7.01 (comp, 2 H), 5.21 (s, 2 H), 4.62 (s, 2 H), 3.71 (t, / = 5.8 Hz, 2 H), 2.85 (br s, 2 H).

The synthetic route of 75416-51-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; MARTIN, Stephen, F.; SAHN, James, J.; LINKENS, Kathryn, Taylor; (119 pag.)WO2017/190109; (2017); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

75416-51-2, 8-Bromo-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,75416-51-2

(a) 8-bromo-l,2,3,4-tetrahydroisoquinoline (64 mg, 0.3 mmol) was dissolved in acetonitrile, K2C03(166 mg, 1.2 mmol) and ethyl 2-bromoacetate (40 mu^, 0.36 mmol) were added. The mixture was stirred at r.t. over night. The solvent was evaporated off, and the residue was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. Purification through flash chromatography on silica gel eluted with 30percent ethyl acetate in hexane gave intermediate ethyl 2-(8-(2-chloro-4- methoxyphenyl)-3,4-dihydroisoquinolin-2(lH)-yl)acetate 73 mg as a brown oil, yield: 86.8percent. LC/MS: (ESI) [M+H]+= 299.2

The synthetic route of 75416-51-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITY OF WASHINGTON; FAN, Erkang; ZHANG, Zhongsheng; HUANG, Wenlin; BUCKNER, Frederick S.; (180 pag.)WO2018/237349; (2018); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem