Category: tetrahydroisoquinoline

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about New insights into the function of the proteins IsiC and IsiD from Synechocystis sp. PCC 6803 under iron limitation, the main research direction is iron proteins Synechocystis nitrogen fixation transcriptome; Co-expression networks; GO and KEGG analysis; Iron deficiency; Synechocystis sp. PCC 6803; WGCNA.HPLC of Formula: 1452-77-3.

Iron is a common cofactor in biol. processes such as respiration, photosynthesis, and nitrogen fixation. The genes isiC and isiD encode unknown proteins, and the growth of ΔisiC and ΔisiD mutants is inhibited under iron-deficient conditions. To study the regulatory mechanisms of IsiC and IsiD during iron starvation, we carried out transcriptome and metabolome sequencing. The Kyoto Encyclopedia of Genes and Genomes (KEGG) anal. showed that the photosynthesis, nitrogen metabolism, and ABC transporter pathways play a vital role in regulating iron deficiency. Upon iron repletion, IsiC and IsiD also have a regulatory effect on these pathways. Addnl., KEGG anal. of the differential metabolites of wild type (WT) and mutants showed that they were all enriched in starch and sucrose metabolism after iron limitation. Weighted gene co-expression network anal. (WGCNA) constructed a co-expression network of differentially expressed genes with phenotypes and metabolites, and finally identified five modules. The turquoise module was pos. correlated with iron deficiency. In contrast, the WT and blue module exhibited a neg. correlation, and the mutants ΔisiC and ΔisiD were pos. correlated with the gray and brown modules, resp. WGCNA also analyzed the relationship between metabolites and phenotypes, and the green module was related to iron starvation. The co-expression network determined the hub genes and metabolites of each module. This study lays a foundation for a better understanding of cyanobacteria in response to iron deficiency.

The article 《New insights into the function of the proteins IsiC and IsiD from Synechocystis sp. PCC 6803 under iron limitation》 also mentions many details about this compound(1452-77-3)HPLC of Formula: 1452-77-3, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1452-77-3, is researched, Molecular C6H6N2O, about New insights into the function of the proteins IsiC and IsiD from Synechocystis sp. PCC 6803 under iron limitation, the main research direction is iron proteins Synechocystis nitrogen fixation transcriptome; Co-expression networks; GO and KEGG analysis; Iron deficiency; Synechocystis sp. PCC 6803; WGCNA.SDS of cas: 1452-77-3.

Iron is a common cofactor in biol. processes such as respiration, photosynthesis, and nitrogen fixation. The genes isiC and isiD encode unknown proteins, and the growth of ΔisiC and ΔisiD mutants is inhibited under iron-deficient conditions. To study the regulatory mechanisms of IsiC and IsiD during iron starvation, we carried out transcriptome and metabolome sequencing. The Kyoto Encyclopedia of Genes and Genomes (KEGG) anal. showed that the photosynthesis, nitrogen metabolism, and ABC transporter pathways play a vital role in regulating iron deficiency. Upon iron repletion, IsiC and IsiD also have a regulatory effect on these pathways. Addnl., KEGG anal. of the differential metabolites of wild type (WT) and mutants showed that they were all enriched in starch and sucrose metabolism after iron limitation. Weighted gene co-expression network anal. (WGCNA) constructed a co-expression network of differentially expressed genes with phenotypes and metabolites, and finally identified five modules. The turquoise module was pos. correlated with iron deficiency. In contrast, the WT and blue module exhibited a neg. correlation, and the mutants ΔisiC and ΔisiD were pos. correlated with the gray and brown modules, resp. WGCNA also analyzed the relationship between metabolites and phenotypes, and the green module was related to iron starvation. The co-expression network determined the hub genes and metabolites of each module. This study lays a foundation for a better understanding of cyanobacteria in response to iron deficiency.

The article 《New insights into the function of the proteins IsiC and IsiD from Synechocystis sp. PCC 6803 under iron limitation》 also mentions many details about this compound(1452-77-3)SDS of cas: 1452-77-3, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Name: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole, is researched, Molecular C18H11Cl2N3O2S, CAS is 882562-40-5, about Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Author is Kwiatkowski, Nicholas; Zhang, Tinghu; Rahl, Peter B.; Abraham, Brian J.; Reddy, Jessica; Ficarro, Scott B.; Dastur, Anahita; Amzallag, Arnaud; Ramaswamy, Sridhar; Tesar, Bethany; Jenkins, Catherine E.; Hannett, Nancy M.; McMillin, Douglas; Sanda, Takaomi; Sim, Taebo; Kim, Nam Doo; Look, Thomas; Mitsiades, Constantine S.; Weng, Andrew P.; Brown, Jennifer R.; Benes, Cyril H.; Marto, Jarrod A.; Young, Richard A.; Gray, Nathanael S..

Tumor oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state, but direct pharmacol. inhibition of transcription factors has so far proven difficult. However, the transcriptional machinery contains various enzymic cofactors that can be targeted for the development of new therapeutic candidates, including cyclin-dependent kinases (CDKs). Here the authors present the discovery and characterization of a covalent CDK7 inhibitor, THZ1, which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell-line profiling indicates that a subset of cancer cell lines, including human T-cell acute lymphoblastic leukemia (T-ALL), have exceptional sensitivity to THZ1. Genome-wide anal. in Jurkat T-ALL cells shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry of these tumor cells. Pharmacol. modulation of CDK7 kinase activity may thus provide an approach to identify and treat tumor types that are dependent on transcription for maintenance of the oncogenic state.

The article 《Targeting transcription regulation in cancer with a covalent CDK7 inhibitor》 also mentions many details about this compound(882562-40-5)Name: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Kinetics of oxidation of dichlorobis(substituted pyridine)platinum(II) and of reduction of tetrachlorobis(substituted pyridine)platinum(IV) complexes, published in 1978, which mentions a compound: 15227-42-6, mainly applied to chloropyridineplatinum complex oxidation reduction kinetics; pyridinechloroplatinum complex oxidation reduction kinetics; platinum pyridine complex oxidation reduction, Name: cis-Dichlorobis(pyridine)platinum(II).

The kinetics of oxidation of cis-[PtCl2L2] (L = py, 3-methyl-, 3- and 4-chloro-, 3- and 4-cyanopyridine) by [AuCl4]- in the presence of [NEt4]Cl and of reduction of cis-[PtCl4L2] by [NEt4]I were studied in MeCN. The rate law for the oxidation reaction was rate = k3[PtCl2L2][AuCl4-][Cl-], where k3 was unaffected by changes in L and had a value ∼100 times higher than that previously found for related phenanthrolineplatinum(II) complexes. The rate law for the reduction reaction was rate = k2[PtCl4L2][I-], where k2 was influenced by the basicity of L, as in related phenanthrolineplatinum(IV) complexes. The kinetic results were discussed in terms of σ and π interactions between the Pt and L.

The article 《Kinetics of oxidation of dichlorobis(substituted pyridine)platinum(II) and of reduction of tetrachlorobis(substituted pyridine)platinum(IV) complexes》 also mentions many details about this compound(15227-42-6)Name: cis-Dichlorobis(pyridine)platinum(II), you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

SDS of cas: 61302-99-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: D-Alanine methylamide hydrochloride, is researched, Molecular C4H11ClN2O, CAS is 61302-99-6, about New Amino Acids for the Topographical Control of Peptide Conformation: Synthesis of All the Isomers of α,β-Dimethylphenylalanine and α,β-Dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid of High Optical Purity. Author is Kazmierski, Wieslaw M.; Urbanczyk-Lipkowska, Zofia; Hruby, Victor J..

The synthesis of all four diastereoisomers of α,β-dimethylphenylalanine, H2NCMe(CHMePh)CO2H, (4) as well as those of α,β-dimethyl-1,2,3,4,-tetrahydroisoquinoline-3-carboxylic acid (I and II) have been accomplished in high yield and high optical purity. Mol. mechanics calculations on the Nα-acetyl and N-methylcarboxamide derivatives of (3R,4R)-I and (3R,4S)-II indicate large and moderate energy stabilization for the gauche(-) but not the gauche(+) side-chain conformers of (3R,4S)-II and (3R,4R)-I, resp. By symmetry rules, the same holds for (3S,4R)-II and (3S,4S)-I, resp. Thus, these amino acids are potential building blocks for the topog. design of peptides (W. M. Kazmierski et al., 1991) by providing acylated 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives in which a gauche(-) and not a gauche(+) side-chain conformation is energetically more stable for the L-amino acid. Synthetic details and implications of these new amino acids for peptide and protein design are discussed.

The article 《New Amino Acids for the Topographical Control of Peptide Conformation: Synthesis of All the Isomers of α,β-Dimethylphenylalanine and α,β-Dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid of High Optical Purity》 also mentions many details about this compound(61302-99-6)SDS of cas: 61302-99-6, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization, the main research direction is Fragment screening; Ligand-protein interaction; Molecular docking; RNA-binding proteins; SPR; STD-NMR.Application In Synthesis of Picolinamide.

Hu proteins are members of the RNA-binding protein (RBP) family and play a pivotal role in the regulation of post-transcriptional processes. Through interaction with selected mRNAs, RBPs regulate their function and stability; as a consequence, RBP dysregulation can cause abnormal translation of key proteins involved in several pathologies. In the past few years, this observation has sparked interest to develop new treatments against these pathologies by using small mols. able to modulate RBP activity. Among the four Hu proteins, we have directed our efforts towards the isoform HuR, which is mainly involved in cancer, inflammation and retinopathy. Aimed at developing compounds able to modulate the stability of HuR-mRNA complexes, in the present work, we applied a biophys. fragment screening by assessing a library of halogen-enriched heterocyclic fragments (HEFLibs) via Surface Plasmon Resonance (SPR) and Saturation Transfer Difference (STD) NMR to select promising fragments able to interact with HuR. One selected fragment and a few com. available congeners were exploited to design and synthesize focused analogs of compound N-(3-chlorobenzyl)-N-(3,5-dihydroxyphenethyl)-4-hydroxybenzamide (1), our previously reported hit. STD NMR spectroscopy, mol. modeling, and SPR offered further insight into the HuR-small mol. interaction and showed that fragment-based approaches represent a promising and yet underexplored strategy to tackle such unusual targets. Lastly, fluorescence polarization (FP) studies revealed the capability of the new compounds to interfere with the formation of the HuR-mRNA complex. This is, to our knowledge, the first fragment-based campaign performed on the Hu protein class, and one of the few examples in the larger RBP field and constitutes an important step in the quest for the rational modulation of RBPs and related RNA functions by small mols.

The article 《Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization》 also mentions many details about this compound(1452-77-3)Application In Synthesis of Picolinamide, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Heterocyclic Chemistry called Synthesis and pancreatic lipase inhibitory activities of some 1,2,4-triazol-5(3)-one derivatives, Author is Ozdemir, Yusuf; Bekircan, Olcay; Baltas, Nimet; Mentese, Emre, which mentions a compound: 693-67-4, SMILESS is CCCCCCCCCCCBr, Molecular C11H23Br, Application In Synthesis of 1-Bromoundecane.

In this study, starting from 4-amino-5-(4-chlorobenzyl)-2,4-dihydro-3H-1,2,4-triazole-3-one, the 4-Amino-5-(4-chlorobenzyl)-2-undecyl-2,4-dihydro-3H-1,2,4-triazol-3-one was first synthesized and this compound was converted to Schiff base derivatives I [R = 4-F, 4-Cl, 2,4-di-F, 2,4-di-Cl, 2-F-4-Cl]. In the second step of the study, the 2-[3-(4-chlorobenzyl)-5-oxo-1-undecyl-1,5-dihydro-4H-1,2,4-triazole-4-yl]-acetohydrazide, which was used as a key product in the synthesis of many heterocyclic compounds was synthesized in four steps, and then this compound was converted into methylidene acetohydrazide II [R = 4-F, 4-Cl, 2,4-di-F, 2,4-di-Cl, 2-F-4-Cl], thiosemicarbazide III [R2 = Me, Et, Ph, Bn, 4-ClC6H4], and 1,2,4-triazole-5-thione IV [R2 = Me, Et, Ph, Bn, 4-ClC6H4; R3 = H] derivatives Also, in the last part of the study, 1,2,4-triazole-5-thione derivatives were changed into Mannich bases IV [R2 = Me, Et, Ph, Bn, 4-ClC6H4; R3 = (4-phenylpiperazin-1-yl)methyl] bearing a 4-phenylpiperazine ring. These new compounds I, II, III and IV were tested with regard to pancreatic lipase (PL) inhibition activity, and compound I [R = 4-Cl, 2,4-di-Cl], II [R = 2,4-di-Cl], III [R2 = Ph] and IV [R2 = Ph; R3 = H] showed a considerable anti-lipase activity at various concentrations The activity of compounds II [R = 4-Cl] (IC50 = 1.45 ± 0.12μM) was the highest in terms of IC50, comparable to that of orlistat, a well-known PL inhibitor used as an antiobesity drug.

The article 《Synthesis and pancreatic lipase inhibitory activities of some 1,2,4-triazol-5(3)-one derivatives》 also mentions many details about this compound(693-67-4)Application In Synthesis of 1-Bromoundecane, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Organometallic Chemistry called Design of organoruthenium complexes for nanoparticle functionalization, Author is Kumar, Saawan; Gallician, Guillaume; Weidener, Dennis; Sullivan, Matthew P.; Sohnel, Tilo; Hanif, Muhammad; Hartinger, Christian G., which mentions a compound: 1452-77-3, SMILESS is O=C(N)C1=NC=CC=C1, Molecular C6H6N2O, Safety of Picolinamide.

In recent years, extensive research efforts have been focused on loading metal complexes onto macromol. systems such as nanoparticles. We report a ligand with a catechol group based on a picolinamide which allows for coordination to organoruthenium moieties while the catechol group remains available for loading on nanoparticles as delivery vehicles towards tumors. All the compounds were characterized with standard anal. methods and the mol. structure of the ligand 1, and its Ru complexes 1a and 1b were determined by X-ray diffraction anal. The crystal structure of 1a and 1b showed pseudo-tetrahedral geometry of the Ru center with “”piano-stool”” conformation and 1 coordinated as an N,O-bidentate ligand, however, the latter depending on the reaction conditions employed. The Ru complexes 1a-1c were effectively loaded on magnetite nanoparticles as characterized by inductively-coupled plasma mass spectrometry (ICP-MS), transmission electron microscopy (TEM) and Fourier transform IR spectroscopy (FTIR).

The article 《Design of organoruthenium complexes for nanoparticle functionalization》 also mentions many details about this compound(1452-77-3)Safety of Picolinamide, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The Guanidine-Promoted Direct Synthesis of Open-Chained Carbonates, published in 2019, which mentions a compound: 693-67-4, mainly applied to linear carbonate preparation green chem; carbon dioxide alc alkyl bromide nucleophilic substitution tetramethylguanidine catalyst, Name: 1-Bromoundecane.

In order to reduce CO2 accumulation in the atm., chem. fixation methodologies were developed and proved to be promising. In general, CO2 was turned into cyclic carbonates by cycloaddition with epoxides. However, the cyclic carbonates need to be converted into open-chained carbonates by transesterification for industrial usage, which results in wasted energy and materials. Herein, a process catalyzed by tetramethylguanidine (TMG) to afford linear carbonates directly is reported. This process is greener and shows potential for industrial applications.

The article 《The Guanidine-Promoted Direct Synthesis of Open-Chained Carbonates》 also mentions many details about this compound(693-67-4)Name: 1-Bromoundecane, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1452-77-3, is researched, Molecular C6H6N2O, about Coupling of CH3OH and CO2 with 2-cyanopyridine for enhanced yields of dimethyl carbonate over ZnO-CeO2 catalyst, the main research direction is methanol carbon dioxide cyanopyridine dimethyl carbonate.Recommanded Product: 1452-77-3.

The present work is aimed to produce di-Me carbonate by coupling of CH3OH and CO2 with 2-cyanopyridine over ZnO-CeO2 catalysts prepared by co-precipitation method. These catalysts were characterized by XRD, TEM, UV-Vis DRS, BET surface area, CO2 and NH3-TPD techniques and applied for the titled reaction. Among the investigated catalysts 10ZnO-90CeO2 catalyst with CeO2 crystallite size 8.0 nm exhibited 96% conversion of methanol with 99% selectivity to di-Me carbonate. The superior catalytic activity is a unified effect of crystalline size of CeO2 and presence of an optimum number of acidic and basic sites. This protocol offers enhanced conversion of methanol with the simultaneous conversion of 2-cyanopyridine into 2-picolinamide by removing water mols. formed in the reaction.

The article 《Coupling of CH3OH and CO2 with 2-cyanopyridine for enhanced yields of dimethyl carbonate over ZnO-CeO2 catalyst》 also mentions many details about this compound(1452-77-3)Recommanded Product: 1452-77-3, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem