Category: tetrahydroisoquinoline

COA of Formula: C11H23Br. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Multiresponse Shape-Memory Nanocomposite with a Reversible Cycle for Powerful Artificial Muscles. Author is Chen, Chi; Liu, Yangyuanchen; He, Ximin; Li, Hua; Chen, Yujie; Wei, Ying; Zhao, Yusen; Ma, Yanfei; Chen, Zhen; Zheng, Xu; Liu, Hezhou.

In the field of bionic soft robots and microrobots, artificial muscle materials have exhibited unique potential for cutting-edge applications. However, current mainstream thermal-responsive artificial muscles based on semicrystalline polymers (SCPs), despite their excellent phys. properties, suffer from the limitation of environmental stimuli in practice, while their photodriven counterparts adopting liquid crystal elastomers (LCEs) lack ductility. Herein, a novel multifunctional programmable artificial muscle with a unique patch-sewing structure formed by π-π stacking between azobenzene groups was designed, which combined the advantages of SCPs and LCEs. The nanocomposite demonstrated a unique combination between artificial muscle performance (46.5 times the energy d. and 26.6 times the power d. of human skeletal muscles) and programmability (274.84% strain and 100% shape-memory recovery rate within 1 s). Meanwhile, coupling the photoisomerization of azobenzene and the photothermal conversion of gold nanorods, the cycle of deformation triggered by UV light and restoring by IR light could be accomplished rapidly within 30 s. A COMSOL Multiphysics model was established and the corresponding finite element anal. verified the photoactuation and captured the general principle of light initiation in elastomers. These demonstrate that the multifunctional programmable elastomer is promising for artificial muscle applications, especially for photoinduced actuation.

Compounds in my other articles are similar to this one(1-Bromoundecane)COA of Formula: C11H23Br, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Zuma, Nonkululeko H.; Smit, Frans J.; Seldon, Ronnett; Aucamp, Janine; Jordaan, Audrey; Warner, Digby F.; N’Da, David D. published the article 《Single-step synthesis and in vitro anti-mycobacterial activity of novel nitrofurantoin analogues》. Keywords: nitrofurantoin preparation antimycobacterial antitumor human drug toxicity; Analogues; Drug resistance; Nitrofurans; Nitrofurantoin; Nitroreductase; Tuberculosis.They researched the compound: 1-Bromoundecane( cas:693-67-4 ).Quality Control of 1-Bromoundecane. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:693-67-4) here.

To improve TB efficacy of nitrofurantoin (NFT), a series of NFT analogs I [R = Me, Et, Bn, etc.] was synthesized and evaluated in vitro for anti-mycobacterial activity against the laboratory strain, Mtb H37Rv and for potential cytotoxicity using human embryonic kidney (HEK-293) and Chinese hamster ovarian (CHO) cells. The NFT analogs showed good safety profiles, enhanced anti-mycobacterial potency, improved lipophilicity, as well as reduced protein binding affinity. Analog I [R = n-Bu] which contains an eight carbon aliphatic chain was the most active, equipotent to isoniazid (INH), a major front-line agent, with MIC90 = 0.5μM, 30-fold more potency than the parent drug, nitrofurantoin (MIC90 = 15μM), and 100-fold more selective towards mycobacteria. Therefore, compound I [R = n-Bu] was identified as a validated hit for further investigation in the urgent search for new, safe and affordable TB drugs.

Compounds in my other articles are similar to this one(1-Bromoundecane)Quality Control of 1-Bromoundecane, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Molecular Liquids called Coumarin substituted symmetric diaminopyridine molecules: Synthesis, mesomorphic characterizations and DFT studies, Author is Mohammad, AbdulKarim-Talaq; Al-Mohammed, Mohammad Hameed; Srinivasa, H. T.; Ameen, Wissam Ahmed, which mentions a compound: 693-67-4, SMILESS is CCCCCCCCCCCBr, Molecular C11H23Br, SDS of cas: 693-67-4.

Synthesis and characterization of 2,6-diaminopyridine bearing sym. substituted coumarins I [R = n-pentyl, n-octyl, n-nonanyl, etc.] from a lateral side of the mols. was reported. All the mols. I were characterized by standard spectroscopic methods such as IR spectroscopy and NMR spectroscopy techniques. Mesomorphic properties were evaluated by the differential scanning calorimetry and the polarized optical microscope. The measurements showed that the lower members did not favor liquid crystal formation, while higher members were exhibiting liquid crystalline, namely nematic mesophase. The DFT computations manifest the nature of liquid crystal geometrical aspects.

Compounds in my other articles are similar to this one(1-Bromoundecane)SDS of cas: 693-67-4, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Li, Jie; Li, Xiang; Yuan, Yan; Wang, Qi; Xie, Lisi; Dai, Yunlu; Wang, Wenjun; Li, Lin; Lu, Xiaomei; Fan, Quli; Huang, Wei published the article 《Efficient Polysulfide-Based Nanotheranostics for Triple-Negative Breast Cancer: Ratiometric Photoacoustics Monitored Tumor Microenvironment-Initiated H2S Therapy》. Keywords: polysulfide nanotheranostic breast cancer photoacoustic tumor microenvironment hydrogen sulfide; hydrogen sulfide; polysulfide; ratiometric photoacoustics; theranostics; triple-negative breast cancer.They researched the compound: 1-Bromoundecane( cas:693-67-4 ).Application of 693-67-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:693-67-4) here.

The incidence of triple-neg. breast cancer (TNBC) is difficult to predict, and TNBC has a high mortality rate among women worldwide. A theranostics approach is developed for TNBC with ratiometric photoacoustic monitored thiol-initiated hydrogen sulfide (H2S) therapy. The ratiometric photoacoustic (PA) probe (CY) with a thiol-initiated H2S donor (PSD) to form a nanosystem (CY-PSD nanoparticles) is integrated. In this theranostics approach, H2S generated from PSD is sensed by CY based on ratiometric PA signals, which simultaneously pinpoints the tumor region. Addnl., H2S is cytotoxic toward TNBC cells (MDA-MB 231), showing a tumor inhibition rate of 63%. To further verify its pharmacol. mechanism, proteomics anal. was performed on tumors treated with CY-PSD nanoparticles. Cells are killed by the significant mitochondrial dysfunction via suppressed energy supply and apoptosis initiation. Besides, the observed inhibition of oxidative stress also generates the cytotoxicity. Significant Kyoto Encyclopedia of Genes Genomes pathways related to TNBC are inhibited. This H2S theranostics approach updates the current anticancer therapies which brings promise for women suffering malignant breast cancer.

Compounds in my other articles are similar to this one(1-Bromoundecane)Application of 693-67-4, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer, published in 2020-07-31, which mentions a compound: 693-67-4, mainly applied to quaternary ammonium compound terphenyl spacer preparation SAR; antibacterial antifungal cytotoxicity human, Related Products of 693-67-4.

Bis-quaternary ammonium compounds I·2 Br- [R = H(CH2)n; n = 7, 8, 9, 10, 11] with a p-terphenyl spacer between two pyridinium heads were synthesized. I·2 Br- (n = 8) was superior to the known benzalkonium chloride, miramistin and chlorhexidine bisgluconate in its MIC values against five pathogenic bacteria.

Compounds in my other articles are similar to this one(1-Bromoundecane)Related Products of 693-67-4, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Bromoundecane(SMILESS: CCCCCCCCCCCBr,cas:693-67-4) is researched.Related Products of 693-67-4. The article 《Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease》 in relation to this compound, is published in ACS Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:693-67-4).

The synthesis of series of lipophilic phenothiazine analogs I (n = 4, 5, 6, 8) that potently inhibit ferroptosis was reported in the present study. The most promising compounds I exhibited an improved protection compared to the parent phenothiazine against erastin- and RSL3-induced ferroptotic cell death. These analogs have equivalent or better potency than ferrostatin-1 (Fer-1) and liproxstatin-1 (Lip-1), which are among the most potent inhibitors of this regulated cell death described so far. They represent novel lead compounds with therapeutic potential in relevant ferroptosis-driven disease models such as FRDA.

Compounds in my other articles are similar to this one(1-Bromoundecane)Recommanded Product: 1-Bromoundecane, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Picolinamide( cas:1452-77-3 ) is researched.Product Details of 1452-77-3.Gu, Yu; Matsuda, Keitaro; Nakayama, Akira; Tamura, Masazumi; Nakagawa, Yoshinao; Tomishige, Keiichi published the article 《Direct Synthesis of Alternating Polycarbonates from CO2 and Diols by Using a Catalyst System of CeO2 and 2-Furonitrile》 about this compound( cas:1452-77-3 ) in ACS Sustainable Chemistry & Engineering. Keywords: carbon dioxide diol copolymerization cerium oxide catalyst furonitrile. Let’s learn more about this compound (cas:1452-77-3).

The control technique of polymer mol. weight is required for the synthesis of versatile polymers with various properties. In our previous work, we found that CeO2 + 2-cyanopyridine catalyst system was effective for the direct synthesis of alternating polycarbonates from CO2 and diols, however, the maximum average mol. weight was ∼1000 g mol-1 (d.p. = 7-8). In this study, we succeeded in the synthesis of alternating polycarbonates with higher mol. weight from CO2 and diols by using a catalyst system of CeO2 + 2-furonitrile. The average mol. weight reached up to 5000 g mol-1 and could be controlled by adjusting the amount of diols and 2-furonitrile. Moreover, polycarbonate diols, polycarbonates without capping of OH groups at the ends, were obtained with the average mol. weight of ∼2000 g mol-1. The catalyst system was applicable to the direct polymerization of CO2 and various α,ω-diols, providing the corresponding alternating polymers. Comparison of CeO2 + 2-cyanopyridine and CeO2 + 2-furonitrile catalyst systems based on the kinetics and DFT calculations showed two main causes for the formation of polycarbonates with higher mol. weight in the CeO2 + 2-furonitrile catalyst system: First, the reactivity of 2-furamide, which was formed from 2-furonitrile, with produced polycarbonate diols was lower than that of 2-picolinamide, which was formed from 2-cyanopyridine, leading to decrease of formation of ester-capped polycarbonates. Second, the adsorption of 2-furonitrile on CeO2 was weaker than that of 2-cyanopyridine, leading to low steric hindrance at the active sites of CeO2 and enabling the reaction of longer diols, such as polycarbonate diols with CO2.

Compounds in my other articles are similar to this one(Picolinamide)Product Details of 1452-77-3, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Electric Literature of C6H6N2O. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Lamotrigine: Design and synthesis of new multicomponent solid forms. Author is Evora, Antonio O. L.; Castro, Ricardo A. E.; Maria, Teresa M. R.; Ramos Silva, M.; Canotilho, Joao; Eusebio, M. Ermelinda S..

In this work, a crystal engineering and thermodn. based approach has been used aiming at contributing to a deeper knowledge of lamotrigine multicomponent solid forms. Two types of co-mols. have been chosen that can give rise to co-crystals with lamotrigine through different supramol. heterosynthons: the xanthines, theophylline and caffeine, and the three isomeric pyridinecarboxamides. Association with diflunisal, which may result in a salt, was also investigated. Mechanochem., differential scanning calorimetry, thermogravimetry, X-ray powder and single crystal diffraction, IR spectroscopy were the methods used. For all the systems, exploratory neat mechanochem. experiments, carried out on lamotrigine + co-mol. binary mixtures of different compositions, were not successful in promoting association From differential scanning calorimetry data and the binary solid-liquid phase diagrams, co-crystals/salts were identified as well as their resp. stoichiometry, and a methodol. of synthesis was established. For pyridinecarboxamides, mol. recognition is dependent on the position of the amide group in the pyridine ring: co-crystallization did not occur with picolinamide co-former. Both xanthines form co-crystals with lamotrigine, (1:1) with theophylline and (2:1) lamotrigine:caffeine. Addnl., the crystalline structure of a lamotrigine:theophylline 1:1 monohydrate was solved. The (1:1) lamotrigine:theophylline co-crystal converts to this monohydrate in accelerated stability tests. A (1:1) lamotrigine:diflunisal salt was identified, which proved to be stable in accelerated stability assays.

Compounds in my other articles are similar to this one(Picolinamide)Electric Literature of C6H6N2O, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Solid-phase condensation of coordinated pyridine and γ-picoline in platinum(II) complexes, the main research direction is thermolysis platinum picoline pyridine complex; condensation picoline pyridine coordinated platinum.SDS of cas: 15227-42-6.

The thermolysis of cis- and trans-[PtL2Cl2] (L = py, γ-picoline (pic)) was studied by IR and 1H NMR spectroscopy. cis-[PtL2Cl2] underwent cis-trans isomerization in the solid state at 200-220°. Thermolysis of trans-[PtL2Cl2] at 240-300° led to condensation of coordinated L to give PtL1Cl2 (L1 = 2,2′-bipyridine, 4,4′-dimethyl-2,2′-bipyridine). Thermolysis of [Pt(pic)4]Cl2 gave trans-Pt(pic)2Cl2 at 160°.

Compounds in my other articles are similar to this one(cis-Dichlorobis(pyridine)platinum(II))SDS of cas: 15227-42-6, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Kukushkin, Yu. N.; Postnikova, E. S. published the article 《Thermal decomposition of pyridine complexes of platinum (II)》. Keywords: thermal decomposition platinum pyridine complex; decomposition thermal platinum pyridine complex; pyridine platinum complex thermal decomposition; platinum pyridine complex decomposition; chloride platinum pyridine complex decomposition; chloride platinum pyridine complex decomposition; geometric isomer platinum pyridine complex; isomer geometric platinum pyridine complex.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Application of 15227-42-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

Thermal anal. of the decomposition of [Pt(py)4]Cl2.3H2O shows that in the initial stage of the reaction there is a joint loss of 2 mols. of pyridine and the H2O of crystallization As a result, trans-[Pt(py)2Cl2] is obtained. The cis-form is somewhat less thermally stable than the trans form. Upon thermal treatment of [Pt(py)4][PtCl4] at 195°, a mixture of geometric isomers of [Pt(py)2Cl2] is obtained.

Compounds in my other articles are similar to this one(cis-Dichlorobis(pyridine)platinum(II))Application of 15227-42-6, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem