Category: tetrahydroisoquinoline

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Appraisal of Ruthenium(II) complexes of (4-phenoxyphenylazo) ligands for the synthesis of primary amides by dint of hydroxylamine hydrochloride and aldehydes, published in 2019-08-30, which mentions a compound: 1452-77-3, Name is Picolinamide, Molecular C6H6N2O, COA of Formula: C6H6N2O.

A new family of O, N donor-functionalized (4-phenoxyphenylazo)-2-naphthol/4-substituted phenol-based ligands (HL1-HL4) has been synthesized. The prepared ligands were successfully utilized for the access of a series of ruthenium(II) carbonyl complexes of the type [Ru(L)Cl(CO)(EPh3)3] (E = phosphine/arsine), (L = 1-(4-phenoxyphenylazo)-2-naphthol (HL1), 2-(4-phenoxyphenylazo)-4-chlorophenol (HL2), 2-(4-phenoxyphenylazo)-4-methylphenol (HL3) and 2-(4-phenoxyphenylazo)-4-methoxyphenol (HL4)). All of the ruthenium(II) carbonyl complexes and ligands have been fully characterized by FT-IR, UV-visible, 1H NMR, 31P NMR, mass spectrometry and CHN anal. The ligands have been analyzed by 13C NMR. The UV-visible spectroscopic study reveals that both the ligands and Ru(II) complexes exhibit excellent charge transfer transitions. This is the basic criteria for the oxidative amidation reaction, which is an influential strategy for the transformation of oxygenated organic compounds to the profitable amides. However, this catalytic process makes more impact on the application of new divalent ruthenium(II) azo compounds as catalyst in a single-pot conversion of aldehydes to amides in the presence of NaHCO3.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Category: tetrahydroisoquinoline. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Cocrystals of hydrochlorothiazide with picolinamide, tetramethylpyrazine and piperazine: quantum mechanical studies, docking and modelling of the photovoltaic efficiency for DSSC. Author is Al-Otaibi, Jamelah S.; Almuqrin, Aljawhara H.; Mary, Y. Sheena; Mary, Y. Shyma; Thomas, Renjith.

Abstract: Cocrystals are of immense applications in crystal engineering and pharmaceutical chem. Hydrochlorothiazide is found to form cocrystals with picolinamide (H1), tetramethylpyrazine (H2) and piperazine (H3). It was characterized using IR spectra, and quantum mech. calculations for geometry and other properties. Frontier orbital energies are used to predict the energy properties and model the possible charge transfer between the constituents of the cocrystal. The frontier MO anal. indicates chem. reactivity and bioactivity of the cocrystals. The MEP surface reveals the various reactive surfaces in the cocrystal system, which is very important in deciding various biol. activities. The UV-Vis spectra show the possible electronic transitions of the mols. Simulated electronic spectra using TDDFT method with CAM-B3LYP functional were used to investigate the suitability of the cocrystals to be used in DSSC. Moreover, the mol. docking anal. proves that the cocrystals can act as potential inhibitors and paves the way for developing effective drugs.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Palladium(II) and platinum(II) saccharinate complexes containing pyridine and 3-acetylpyridine: Synthesis, crystal structures, fluorescence and thermal properties, the main research direction is preparation palladium platinum saccharinate pyridine acetylpyridine complex; crystal structure palladium platinum saccharinate pyridine acetylpyridine complex; fluorescence platinum saccharinate pyridine acetylpyridine complex.Category: tetrahydroisoquinoline.

New Pd(II) and Pt(II) complexes of saccharinate (sac), trans-[Pd(py)2(sac)2] (1), cis-[Pt(py)2(sac)2] (2), trans-[Pd(3-acpy)2(sac)2] (3) and cis-[Pt(3-acpy)2(sac)2] (4) (py = pyridine and 3-acpy = 3-acetylpyridine) were synthesized. Elemental anal., UV-visible, IR, NMR and TG/DTA characterizations were carried out. The structures of 1-4 were determined by x-ray diffraction. The Pd(II) and Pt(II) ions are coordinated by two N-bonded sac ligands, and two N atoms of py or 3-acpy, forming a distorted square-planar geometry. The Pd(II) complexes (1 and 3) are trans isomers, while the Pt(II) complexes (2 and 4) are cis isomers. The mononuclear species in the solid state are connected by weak intermol. C-H···O H bonds, C-H···π and π···π stacking interactions. The Pt(II) complexes show significant fluorescence at room temperature

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Anisotropic, Organic Ionic Plastic Crystal Mesophases from Persubstituted Imidazolium Pentacyanocyclopentadienide Salts, published in 2019-12-10, which mentions a compound: 693-67-4, mainly applied to persubstituted imidazolium pentacyanocyclopentadienide salt anisotropic organic ionic plastic crystal, Electric Literature of C11H23Br.

We describe the synthesis, supramol. organization, and thermal characteristics of an unprecedented family of sym. 1,2,3,4,5-pentaalkylimidazolium ([(Cn)5i.m.]+) salts equipped with halide, nitrate, or pentacyanocyclopentadienide ([Cp(CN)5]-) counterions. Salts containing relatively small anions were obtained as low-melting solids, whereas those with [Cp(CN)5]- anions were found to be ionic liquids even below room temperature A permethylated derivative, [(C1)5i.m.][Cp(CN)5], proved to be exceptional. Upon heating, the salt self-organized into a new type of organic ionic plastic crystal (OIPC) mesophase, which was termed Mhex and whose anisotropic structure featured hexagonally ordered, rotating anionic stacks positioned within a continuum composed of disordered cations. The structure of the mesophase resembles that of classical columnar liquid-crystalline phases, despite the absence of long, flexible chains. In the Mhex phase, the cations surrounding the anionic columns effectively fulfill the role of “”softening”” structural constituents, much in the same way as flexible chains. The discovery of the novel mesophase, which displays a two-dimensional, and thus intrinsically anisotropic, lattice resulting from the rotation of entire ionic assemblies around a columnar axis, represents a new paradigm in the field of OIPCs. Relatively high ionic conductivities were measured in the Mhex phase, particularly after doping with the corresponding sodium salt, Na[Cp(CN)5], demonstrating the materials’ potential for use in electrochem. applications such as sodium-ion batteries.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1452-77-3, is researched, Molecular C6H6N2O, about Understanding the extraction behaviour of UO2+2 and Th4+ using novel picolinamide/N-oxo picolinamide in ionic liquid: A comparative evaluation with molecular diluent, the main research direction is uranium oxide ligand diluent viscosity cation exchange thermodn extraction.Electric Literature of C6H6N2O.

The manuscript deals with efficient separation of hexavalent UO2+2 and tetravalent Th4+ from aqueous acidic waste solution in green way using ionic liquid with novel picolinamide (L I) and N-oxo picolinamide (L II) based ligands. A comparative evaluation was carried out to understand the extraction mechanism, kinetics, thermodn., speciation, radiolytic stability and stripping behavior of UO2+2 and Th4+ in ionic liquid vis-a-vis mol. diluent. The investigation demonstrates the predominance of cation exchange mechanism in ionic liquid and solvation mechanism in n-dodecane based systems. The slower extraction kinetics in ionic liquid was attributed to the viscosity effect. The extractive mass transfer processes were found to be spontaneous, endothermic and entropically driven in nature. The picolinamide and N-oxo picolinamide ligands were found to form inner-sphere complexes in ionic liquid as well as n-dodecane. The CO2-3 was more effective aqueous phase complexing agent to back extract UO2+2, while C2O2-4 exhibited the same for Th4+.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Multistate luminescence, absorption and MCD studies of the relative energies of d → d, d → π*, and n,π → π* transitions for the cis and trans isomers of dichlorobis(pyridine)platinum(II), published in 1983-02-16, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Formula: C10H10Cl2N2Pt.

Luminescence, absorption, and magnetic CD (MCD) experiments are reported for cis- and trans-dichlorobis(pyridine)platinum(II). For the trans isomer, an anal. of the temperature dependence of the lifetimes and luminescence intensities indicates that emission at 605 nm is from 2 excited π* states separated by 240 cm-1. For the cis isomer, time-resolved spectroscopy allowed observation of 2 emission bands at 600 and 700 nm, which were assigned from their lifetimes to π* → d and d → d transitions, resp. Further, temperature dependent lifetime studies show that the 600-nm band (π* → d) is from 2 electronic states separated by 200 cm-1. The absorption spectra of both isomers were measured at room and low temperatures in solution, in glasses, and in KCl pellets. From a comparison with the pyridine and Pt(NH3)2Cl2 absorption and MCD spectra and MO calculations, the observed absorption bands for Pt(py)2Cl2 are assigned as d → d, d → π*, and n, π → π* transitions. For the cis isomer the lowest unoccupied mol. orbital is a d metal orbital.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Antitumor activity of Group VIII transition metal complexes. I. Platinum(II) complexes, published in 1973, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Name: cis-Dichlorobis(pyridine)platinum(II).

A wide variety of Pt(II) complexes were studied for antitumor activity against Sarcoma 180 in female mice. In general only neutral complexes exhibited activity, whereas charged species were inactive and relatively nontoxic. A series of complexes of the type cis-[PtA2X2] (where A2 is either 2 monodentate or 1 bidentate amine ligand and X2 is either 2 monodentate or 1 bidentate anionic ligand) were studied with A and B being systematically varied. At least 10 potentially active antitumor drugs were identified, including cis-dichlorbis(methylamine)platinum(2+) [15273-32-2], diamminepropanedioatoplatinum(2+) [38780-43-7], and (1,2-ethanediammine-N,N’)(2-methylpropanedioato)platinum(2+) [41575-97-7]. The trans isomers were inactive in comparison with active cis complexes, so the presence of cis-reactive ligands seems to be a necessary parameter for antitumor activity. Complexes with highly reactive ligands such as cis-[Pt(NH3)2 (H2O)2](NO3)2 were highly toxic. Pd(II) complexes analogous to the active Pt(II) compounds were themselves inactive.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Thermal isomerization of complex platinum(II) compounds, the main research direction is platinum amine complex isomerization; sulforide platinum complex isomerization; ammine platinum complex isomerization; pyridine platinum complex isomerization.Safety of cis-Dichlorobis(pyridine)platinum(II).

The thermal cis-trans isomerization of [PtA2I2] complexes, where A = NH3, MeNH2, EtNH2, pyridine, was studied by derivatography. The heat of isomerization is 1-7 kcal/mole. trans-[Pt(R2SO)ACl2]-type complexes melt upon heating and isomerize in the melt. The isomerization reaction proceeds through formation of a tetrahedral intermediate.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Colangelo, Donato; Ghiglia, AnnaLisa; Viano, Ilario; Mahboobi, Homa; Ghezzi, AnnaRita; Cassino, Claudio; Osella, Domenico published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Category: tetrahydroisoquinoline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

Telomerase is a ribonucleoprotein polymerase that synthesizes telomeric DNA (TTAGGG) repeats. Previously, we have studied the effect on telomerase enzyme of several cis-platinum(II) complexes bearing aromatic amines as bulky carrier groups. All these complexes possess cis-geometry, according to the Cleare and Hoschele’s rule. Since recent reports have dealt with the anti-cancer activity of trans-platinum compounds, in this study we have investigated the Farrell’s prototypical trans-[Pt(Cl)2(pyridine)2], hereafter called trans-PtPy, to understand whether it may possess any anti-telomerase activity. The trans-PtPy has low water solubility and requires DMSO as co-solvent, thus making the biol. tests problematic. The effect of trans-PtPy on MCF-7 cell line concerning log-term telomerase inhibition, telomerase-related gene expression, viability, and apoptosis was evaluated. In a cell-free biochem. assay, trans-PtPy showed significant and dose-dependent inhibition of semi-purified telomerase. The bulk of data indicate that trans-PtPy acts as a non-properly selective anti-proliferative agent, although it shows an initial telomerase inhibitory effect. Telomere length reduction seems not to be the main mechanism causing the observed cell apoptosis. For comparison purpose, results on cis-[Pt(Cl)2(pyridine)2] are reported.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Iyo Masu Kenkyukai Koenshu called Mass spectrometry of cis-platin in urine, Author is Sumino, Kimiaki; Mio, Takaya; Yamamoto, Ryoji; Ishigami, Joji; Kamidono, Sadao; Hamami, Gaku, which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Electric Literature of C10H10Cl2N2Pt.

The mass spectra of cisplatin  [15663-27-1] and its analogs are presented. A urine sample of a cancer patient treated with cisplatin was extracted with 0.1N-HCl and then washed with COMe2/CHCl3. The component containing Pt was eluted with 2N-HBr using an ion exchange chromatog. technique. The mass spectrum of the component showed the change from Cl-type to Br-type as the unchanged type of carrier ligand. Thus, mass spectrometry may be a useful method to elucidate the action mechanism of cisplatin.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem