Category: tetrahydroisoquinoline

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Ionic liquid crystals: Synthesis and characterization via NMR, DSC, POM, X-ray diffraction and ionic conductivity of asymmetric viologen bistriflimide salts.Reference of 1-Bromoundecane.

A series of asym. viologen bistriflimide salts I (R = n-pentyl, dodecyl, octadecyl, etc.) of both short and long alkyl chains were synthesized by the metathesis reaction of lithium triflimide salt with the resp. asym. viologen dibromide salts II in methanol. Their thermotropic liquid crystalline properties were determined by differential scanning calorimetry, polarizing optical microscopy and variable temperature X-ray diffraction techniques. These salts melt into highly-ordered smectic T phases i.e., crystal-to SmT transitions (Tms) at relatively low temperatures (lowest Tm at -12°C) and maintain liquid crystallinity in a wide range of temperatures (8-132°C), with excellent thermal stabilities up to 320°C as determined by thermogravimetric anal. These results differ with respect to the sym. viologen bistriflimide salts I. Ionic conductivity of these salts was also measured by dielec. impedance spectroscopy and found to be in the 10-2.5 S cm-1 range, highlighting their potential as electrolytes at room temperature

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Validation Study, Journal of Inorganic Biochemistry called The RP-HPLC measurement and QSPR analysis of log Po/w values of several Pt(II) complexes, Author is Platts, James A.; Oldfield, Steven P.; Reif, Maria M.; Palmucci, Alessandra; Gabano, Elisabetta; Osella, Domenico, which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Synthetic Route of C10H10Cl2N2Pt.

The n-octanol/water partition coefficient, log Po/w, for a set of 24 Pt(II)-complexes was estimated by means of reversed-phase high performance liquid chromatog. (RP-HPLC) technique using a C18 (ODS, octadecyl silane) column as a stationary phase and water/methanol mixtures as mobile phases. Based on the known log P o/w of several Pt(II)-complexes, the authors set a method to correlate the partition coefficient of this kind of complexes with the corresponding retention parameters. The best result was obtained from extrapolation to 0% of the organic modifier (MeOH) of the aqueous eluant. A quant. structure-property relationship (QSPR) was constructed using mol. descriptors derived from d. functional theory (DFT) calculations, which was found to correlate and predict these values with good accuracy. The use of DFT calculations is required because group-additive methods fail due to lack of values for appropriate fragments for many Pt(II)-complexes.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called δ-Valerolactamic quaternary amino acid derivatives: Enantiodivergent synthesis and evidence for stereodifferentiated β-turn-inducing properties, Author is Zhang, Xiaofei; Ligny, Romain; Chewchanwuttiwong, Sopa; Hadade, Rawan; Laurent, Mathieu Y.; Martel, Arnaud; Jacquemmoz, Corentin; Lhoste, Jerome; Bricaud, Sullivan; Py, Sandrine; Dujardin, Gilles, which mentions a compound: 61302-99-6, SMILESS is N[C@H](C)C(NC)=O.[H]Cl, Molecular C4H11ClN2O, Name: D-Alanine methylamide hydrochloride.

Enantiopure (R) and (S) cyclic α,α-disubstituted amino acid derivatives displaying a δ-valerolactam side chain were prepared from a common isoxazolidine precursor. The (R)-configured δ-valerolactam (I) was converted into diastereoisomeric pseudopeptides to investigate its ability to induce secondary structures in peptidomimetics. Conformational studies of these pseudopeptides were carried out in the solid state (X-ray diffraction), in solution (NMR analyses), and in silico (computer-aided conformational anal.), which demonstrated that such quaternary amino acids induce β-turn conformations stable enough to be retained in polar media (DMSO). Incorporation of this new type of α,α-disubstituted amino acid into a representative pseudopeptidic sequence by N- then C-elongation and N-debenzylation is also described herein and could serve for the synthesis of various structured peptidomimetics.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: 1452-77-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Bis(N-picolinamido)cobalt(II) Complexes Display Antifungal Activity toward Candida albicans and Aspergillus fumigatus. Author is Ghandhi, Laura H. D.; Bidula, Stefan; Pask, Christopher M.; Lord, Rianne M.; McGowan, Patrick C..

This report highlights the synthesis and characterization of ten new bis(N-picolinamido)cobalt(II) complexes of the type [(L)2CoX2]0/2+, whereby L=N-picolinamide ligand and X=diisothiocyanato (-NCS), dichlorido (-Cl) or diaqua (-OH2) ligands. Single crystal X-ray (SC-XRD) anal. for nine of the structures are reported and confirm the picolinamide ligand is bound to the Co(II) center through a neutral N,O binding mode. With the addition of powder X-ray diffraction (PXRD), we have confirmed the cis and trans ligand arrangements of each complex. All complexes were screened against several fungal species and show increased antifungal activity. Notably, these complexes had significant activity against strains of Candida albicans and Aspergillus fumigatus, with several compounds exhibiting growth inhibition of >80 %, and onecompound inhibiting Aspergillus fumigatus hyphal growth by >90 %. Conversely, no antifungal activity was exhibited toward Cryptococcus neoformans and no cytotoxicity towards mammalian cell lines.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Name: cis-Dichlorobis(pyridine)platinum(II). Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Rearrangement of a platinum(II) complex in DNA from intercalation outer-sphere position to non-intercalation coordination. Author is Norden, Bengt.

The interaction of I with DNA was studied using linear dichroism and absorption spectra of DNA solutions containing different concentrations of I. The initial complex had a stability constant of 3 × 105M-1 and the orientation of the I plane was angular, indicating that binding was by intercalation. This intercalated complex slowly transformed into a more stable complex with the orientation of the I plane parallel to the helix axis. In this complex there was coordination of I to N atoms of DNA bases. This complex involved the inner sphere of DNA. When II interacted with DNA, a complex was formed in which inner sphere coordination was present; II did not intercalate with DNA.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Application of 15227-42-6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Luminescence properties of some platinum(II) complexes. Counter-ion and molecular geometry effects. Author is Diomedi Camassei, F.; Ancarani-Rossiello, L.; Castelli, F..

Reflectance and luminescence spectra, and emission lifetimes of 14 charged and neutral Pt(II) crystalline complexes are reported. The lifetimes (in the range of some tens of μsec) indicate that the emissions are due to a spin-forbidden process. On the basis of spectral correlations, the phosphorescence is tentatively identified as due to the lowest d-d ligand field transition when the bonding of the ligand is essentially σ in character, and to a π* → d charge-transfer transition for those complexes in which the ligands themselves have π orbital systems. Both the radiative (kr) and nonradiative (kn) rate constants are sensitive to changes in mol. geometry (cis,trans isomers) and counter-ions. By assuming unitary efficiency for the intersystem crossing to the emitting state, the counter-ion appears to predominantly affect kn through vibrational coupling of the chromophore with the lattice. For the cis forms, both kr and kn are affected in a complex manner, with metal-metal interactions playing an important role. For the trans forms, however, the constancy of the quantum yield with respect to temperature suggests that kn is negligible in comparison to kr, and therefore the trans chromophores behave as isolated systems within the crystalline lattice.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 693-67-4, is researched, Molecular C11H23Br, about Solvent Dependence of the Monomer-Dimer Equilibrium of Ketone-Substituted Triscatecholate Titanium(IV) Complexes, the main research direction is titanium triscatecholate preparation monomer dimer equilibrium solvent effect; helicates; intermolecular interactions; self assembly; solvent effect; thermodynamics.Computed Properties of C11H23Br.

Hierarchical helicates based on ketone-substituted titanium(IV)triscatecholates show different monomer-dimer behavior depending on different solvents. The dimerization constants of a whole series of differently alkyl-substituted complexes is analyzed to show that the solvent has a very strong influence on the dimerization. Hereby, effects like solvophobicity/philicity, sterics, electronics of the substituents and weak side-chain-side-chain interactions seem to act in concert.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cleare, Michael J.; Hoeschele, J. D. researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).SDS of cas: 15227-42-6.They published the article 《Antitumor platinum compounds. Relation between structure and activity》 about this compound( cas:15227-42-6 ) in Platinum Metals Review. Keywords: platinum complex structure cancer; antitumor platinum complex structure. We’ll tell you more about this compound (cas:15227-42-6).

A pair of cis leaving groups is necessary but not sufficient for anticancer activity in Pt(II) complexes. The complex should be neutral and the lability of the leaving groups should be about that of Cl in cis-dichlorodiammineplatinum(II) [15663-27-1]. The other ligands should be relatively inert and neutral. Amines are preferred, although varying their structure has not given a clear pattern. However the activity of compounds containing alicyclic amines indicates that some Pt compounds may be highly selective.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Chromatographia called A new stationary phase for capillary gas chromatography: Calix[4]resorcinarene functionalized with imidazolium cationic units, Author is Shuai, Xiaomin; Cai, Zhiqiang; Zhao, Xinyu; Chen, Yujie; Zhang, Qian; Ma, Ziwei; Hu, Junjie; Sun, Tao; Hu, Shaoqiang, which mentions a compound: 693-67-4, SMILESS is CCCCCCCCCCCBr, Molecular C11H23Br, SDS of cas: 693-67-4.

A novel calix[4]resorcinarene-based ionic liquid (C4RA-2IL) was synthesized, structurally characterized, and statically coated on capillary column as stationary phase for capillary gas chromatog. (GC). The column efficiency of the C4RA-2IL column is 3345 plates m-1, which are determined by n-dodecane at 120 °C. Based on its McReynolds constants, the C4RA-2IL column showed moderate polarity. Particularly, the C4RA-2IL column show high separation performance for a wide range of analytes and some difficult separation of meta/para-isomers. Moreover, it exhibited excellent selectivity for critical aromatic isomers of chloroaniline, bromaniline, iodoaniline, toluidine and xylidine isomers and shows advantageous separation capability over the com. polysiloxane stationary phase. This work presents a promising future of calixarene-based ionic liquid as a new type of stationary phase in GC separations

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Picolinamide(SMILESS: O=C(N)C1=NC=CC=C1,cas:1452-77-3) is researched.SDS of cas: 693-67-4. The article 《Effect of nicotinamide on the flagellar detachment and regeneration of Euglena》 in relation to this compound, is published in Bitamin. Let’s take a look at the latest research on this compound (cas:1452-77-3).

Euglena is capable of growth under various variety of nutritional and environmental conditions. Euglena is possible to grow under diverse culture conditions with and without light illumination, namely under both heterotrophic and photoautotrophic conditions. Euglena can synthesize most of vitamins and biofactors except for the exception, such as vitamin B1 and B12. In the present study, the effects of nicotinamide and its analogs on the flagellar detachment of Euglena were investigated using nicotinamide and the 12 kinds of structural analogs (nicotinic acid, pyrazine, pyrazine-2-carboxylic acid, 2-picolinamide, methylnicotinate, N-methylnicotinamide, 3-methylpyridine, pyridine-3-sulfate, pyridoxine, pyridoxal, pyridoxamine, isonicotinic acid hydrazide), NAD+, and NADP+. Among these compounds, nicotinamide, nicotinic acid, pyrazine-2-carboxylic acid, methylnicotinate, 2-picolinamide, and N-methylnicotinamide caused of the flagellar detachment and then cell division stopped. It was also found that nicotinamide added to Euglena cell was dilute with water and culture medium, cell division occurred and then flagella were regenerated after 24h, resulting in onset euglenoid exercise. The electrophoresis of the detached flagellar proteins reveled that the protein resembled tublin (55 kDa) and paraflagella rod 2 (69 KDa).

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem