Category: tetrahydroisoquinoline

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Ionic liquid crystals: Synthesis and characterization via NMR, DSC, POM, X-ray diffraction and ionic conductivity of asymmetric viologen bistriflimide salts.Reference of 1-Bromoundecane.

A series of asym. viologen bistriflimide salts I (R = n-pentyl, dodecyl, octadecyl, etc.) of both short and long alkyl chains were synthesized by the metathesis reaction of lithium triflimide salt with the resp. asym. viologen dibromide salts II in methanol. Their thermotropic liquid crystalline properties were determined by differential scanning calorimetry, polarizing optical microscopy and variable temperature X-ray diffraction techniques. These salts melt into highly-ordered smectic T phases i.e., crystal-to SmT transitions (Tms) at relatively low temperatures (lowest Tm at -12°C) and maintain liquid crystallinity in a wide range of temperatures (8-132°C), with excellent thermal stabilities up to 320°C as determined by thermogravimetric anal. These results differ with respect to the sym. viologen bistriflimide salts I. Ionic conductivity of these salts was also measured by dielec. impedance spectroscopy and found to be in the 10-2.5 S cm-1 range, highlighting their potential as electrolytes at room temperature

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Validation Study, Journal of Inorganic Biochemistry called The RP-HPLC measurement and QSPR analysis of log Po/w values of several Pt(II) complexes, Author is Platts, James A.; Oldfield, Steven P.; Reif, Maria M.; Palmucci, Alessandra; Gabano, Elisabetta; Osella, Domenico, which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Synthetic Route of C10H10Cl2N2Pt.

The n-octanol/water partition coefficient, log Po/w, for a set of 24 Pt(II)-complexes was estimated by means of reversed-phase high performance liquid chromatog. (RP-HPLC) technique using a C18 (ODS, octadecyl silane) column as a stationary phase and water/methanol mixtures as mobile phases. Based on the known log P o/w of several Pt(II)-complexes, the authors set a method to correlate the partition coefficient of this kind of complexes with the corresponding retention parameters. The best result was obtained from extrapolation to 0% of the organic modifier (MeOH) of the aqueous eluant. A quant. structure-property relationship (QSPR) was constructed using mol. descriptors derived from d. functional theory (DFT) calculations, which was found to correlate and predict these values with good accuracy. The use of DFT calculations is required because group-additive methods fail due to lack of values for appropriate fragments for many Pt(II)-complexes.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called δ-Valerolactamic quaternary amino acid derivatives: Enantiodivergent synthesis and evidence for stereodifferentiated β-turn-inducing properties, Author is Zhang, Xiaofei; Ligny, Romain; Chewchanwuttiwong, Sopa; Hadade, Rawan; Laurent, Mathieu Y.; Martel, Arnaud; Jacquemmoz, Corentin; Lhoste, Jerome; Bricaud, Sullivan; Py, Sandrine; Dujardin, Gilles, which mentions a compound: 61302-99-6, SMILESS is N[C@H](C)C(NC)=O.[H]Cl, Molecular C4H11ClN2O, Name: D-Alanine methylamide hydrochloride.

Enantiopure (R) and (S) cyclic α,α-disubstituted amino acid derivatives displaying a δ-valerolactam side chain were prepared from a common isoxazolidine precursor. The (R)-configured δ-valerolactam (I) was converted into diastereoisomeric pseudopeptides to investigate its ability to induce secondary structures in peptidomimetics. Conformational studies of these pseudopeptides were carried out in the solid state (X-ray diffraction), in solution (NMR analyses), and in silico (computer-aided conformational anal.), which demonstrated that such quaternary amino acids induce β-turn conformations stable enough to be retained in polar media (DMSO). Incorporation of this new type of α,α-disubstituted amino acid into a representative pseudopeptidic sequence by N- then C-elongation and N-debenzylation is also described herein and could serve for the synthesis of various structured peptidomimetics.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: 1452-77-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Bis(N-picolinamido)cobalt(II) Complexes Display Antifungal Activity toward Candida albicans and Aspergillus fumigatus. Author is Ghandhi, Laura H. D.; Bidula, Stefan; Pask, Christopher M.; Lord, Rianne M.; McGowan, Patrick C..

This report highlights the synthesis and characterization of ten new bis(N-picolinamido)cobalt(II) complexes of the type [(L)2CoX2]0/2+, whereby L=N-picolinamide ligand and X=diisothiocyanato (-NCS), dichlorido (-Cl) or diaqua (-OH2) ligands. Single crystal X-ray (SC-XRD) anal. for nine of the structures are reported and confirm the picolinamide ligand is bound to the Co(II) center through a neutral N,O binding mode. With the addition of powder X-ray diffraction (PXRD), we have confirmed the cis and trans ligand arrangements of each complex. All complexes were screened against several fungal species and show increased antifungal activity. Notably, these complexes had significant activity against strains of Candida albicans and Aspergillus fumigatus, with several compounds exhibiting growth inhibition of >80 %, and onecompound inhibiting Aspergillus fumigatus hyphal growth by >90 %. Conversely, no antifungal activity was exhibited toward Cryptococcus neoformans and no cytotoxicity towards mammalian cell lines.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Antitumor platinum compounds. Relation between structure and activity.Product Details of 15227-42-6.

A pair of cis leaving groups is necessary but not sufficient for anticancer activity in Pt(II) complexes. The complex should be neutral and the lability of the leaving groups should be about that of Cl in cis-dichlorodiammineplatinum(II) [15663-27-1]. The other ligands should be relatively inert and neutral. Amines are preferred, although varying their structure has not given a clear pattern. However the activity of compounds containing alicyclic amines indicates that some Pt compounds may be highly selective.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Binding of antitumor platinum compound to cells as influenced by physical factors and pharmacologically active agents, published in 1973, which mentions a compound: 15227-42-6, mainly applied to tumor cell platinum compound binding, Category: tetrahydroisoquinoline.

Tritiated cis-dichloro(dipyridine)platinum(II) (I) [15227-42-6] bound to intact Ehrlich ascites tumor cells at 37.deg. in vitro and remained associated with the acid-insoluble fraction of the cells. The extent of binding was also increased with increasing hydrogen ion [1333-74-0] concentration in the medium. The binding was enhanced markedly at 60.deg. and the maximum number of binding sites/cell was .sim.7 billion at this temperature Of 49 chems. and drugs tested, none decreased appreciably the rate and extent of binding, whereas certain heavy metals, and compounds that compromise membrane permeability enhanced the binding. Human and bovine lymphocytes had similar binding characteristics, but bound much more I/unit of cell volume.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Density functional theory and surface enhanced Raman spectroscopy characterization of novel platinum drugs, published in 2002, which mentions a compound: 15227-42-6, mainly applied to anticancer platinum complex density functional theory; Raman spectroscopy anticancer platinum complex, Application of 15227-42-6.

There is considerable interest in the development of novel platinum-based anticancer drugs that overcome the disadvantages associated with the widely used drug cisplatin, which are its inactivity against some types of tumors and its toxic side effects. In this study we show the suitability of normal Raman spectroscopy (NRS) and surface enhanced Raman spectroscopy (SERS), assisted by d. functional theor. (DFT) calculations, for the characterization of Pt complexes. The Pt complexes studied include the established drugs cisplatin and carboplatin, as well as five novel Pt complexes with anticancer activity. DFT calculations at the B3LYP/LanL2DZ level are a good prediction of the exptl. NRS spectra of small and medium sized Pt complexes. The use of SERS allows the investigation of Pt complexes at physiol. concentrations, and the binding strengths of the different ligands can be determined The formation of pos. charged hydrolysis products may be necessary for SERS activity. The existing group in the hydrolysis reaction can be identified.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Computed Properties of C10H10Cl2N2Pt. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Reactions of potassium tetrachloroplatinate(II) with pyridine derivatives in dimethylformamide and synthesis of potassium trichloro(pyridine)platinum(II). Author is Kong, Pi-Chang; Rochon, F. D..

The reactions of K2PtCl4 with pyridine derivatives L (L = py = pyridine, pic = picoline, and lut = lutidine) were studied in DMF. K[PtLCl3] (I) were isolated and the yield decreased with the order, 2,4-lut = 2-pic > 2,6-lut > 4-pic = py, which can be correlated to the steric hindrance of the ortho Me groups. Cis-[PtL2Cl2] (II) is the final product of the reactions. Trans-[PtL2Cl2] (III) can also be obtained from a DMF solution of [Pt(L)4]Cl2 (L = py) at room temperature A comparison of the above reactions in H2O and in DMF was also made.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Ali, Imdad; Manzoor, Hiba; Imran, Muhamad; Shafiulah; Shah, Muhammad Raza published an article about the compound: 1-Bromoundecane( cas:693-67-4,SMILESS:CCCCCCCCCCCBr ).Category: tetrahydroisoquinoline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:693-67-4) through the article.

Nonionic surfactants are increasingly interesting because of the solubility and release of drugs. Here, a synthesis of four nonionic nitrogen-containing surfactants is reported. In the synthesis, sulfonamide was reacted with alkyl halides of different lipophilicity. The synthesized nonionic surfactants were characterized by 1H NMR and mass spectroscopy. Their critical micelle concentration (CMC) was determined with a UV spectrophotometer. The self-assembly of surfactants to form drug-loaded, niosomal vesicles with Simvastatin as model drug was investigated. The resulting niosoaml vesicles were characterized by at. force microscope (AFM), zeta-sizer, and UV spectrophotometer for shape, size, polydispersity index, zeta potential, and drug inclusion efficiency. Their biocompatibility has been determined by blood hemolysis and cell toxicity tests. The synthesized surfactants showed low CMC values and were able to form nano-sized round niosomal vesicles with a homogeneous population and surface negativity. Depending on the lipophilicity, they absorbed an increased amount of drug. The biocompatibility studies show that the surfactants are hemocompatible and non-toxic. The results of the study confirm that the synthesized nonionic surfactants are suitable for the solubilization and release of hydrophobic drugs as efficient novel biocompatible carriers.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Product Details of 15227-42-6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Reactivity of geometric isomers of (-)-dichloropyridine(methyl p-tolyl sulfoxide)platinum(II) by optical rotatory dispersion. Author is De Vekki, D. A.; Spevak, V. N.; Skvortsov, N. K..

The reactions of the optically active geometric isomers of (-)-[Pt(Me-p-TolSO)(Py)Cl2] with several nucleophilic reagents (py, Ph3PS, Ph3P, Ph3As, and Me2SO) were studied by ORD, IR spectroscopy, and 1H and 31P NMR spectroscopy. A mechanism for the reaction is proposed.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem