Category: tetrahydroisoquinoline

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Dichlorobis(pyridine)platinum(II)(SMILESS: [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2,cas:15227-42-6) is researched.HPLC of Formula: 693-67-4. The article 《Kinetics of oxidation of dichlorobis(substituted pyridine)platinum(II) and of reduction of tetrachlorobis(substituted pyridine)platinum(IV) complexes》 in relation to this compound, is published in Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999). Let’s take a look at the latest research on this compound (cas:15227-42-6).

The kinetics of oxidation of cis-[PtCl2L2] (L = py, 3-methyl-, 3- and 4-chloro-, 3- and 4-cyanopyridine) by [AuCl4]- in the presence of [NEt4]Cl and of reduction of cis-[PtCl4L2] by [NEt4]I were studied in MeCN. The rate law for the oxidation reaction was rate = k3[PtCl2L2][AuCl4-][Cl-], where k3 was unaffected by changes in L and had a value ∼100 times higher than that previously found for related phenanthrolineplatinum(II) complexes. The rate law for the reduction reaction was rate = k2[PtCl4L2][I-], where k2 was influenced by the basicity of L, as in related phenanthrolineplatinum(IV) complexes. The kinetic results were discussed in terms of σ and π interactions between the Pt and L.

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1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 882562-40-5, is researched, SMILESS is ClC1=NC(C2=CN(C3=C2C=CC=C3)S(=O)(=O)C2=CC=CC=C2)=C(Cl)C=N1, Molecular C18H11Cl2N3O2SJournal, Article, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Targeting the Gatekeeper MET146 of C-Jun N-Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond, Author is Lange, Andreas; Guenther, Marcel; Buettner, Felix Michael; Zimmermann, Markus O.; Heidrich, Johannes; Hennig, Susanne; Zahn, Stefan; Schall, Christoph; Sievers-Engler, Adrian; Ansideri, Francesco; Koch, Pierre; Laemmerhofer, Michael; Stehle, Thilo; Laufer, Stefan A.; Boeckler, Frank M., the main research direction is aminopyrimidine inhibitor halogen chalcogen bond methionine JNK3 crystal structure.Category: tetrahydroisoquinoline.

We target the gatekeeper MET146 of c-Jun N-terminal kinase 3 (JNK3) to exemplify the applicability of X···S halogen bonds in mol. design using computational, synthetic, structural and biophys. techniques. In a designed series of aminopyrimidine-based inhibitors, we unexpectedly encounter a plateau of affinity. Compared to their QM-calculated interaction energies, particularly bromine and iodine fail to reach the full potential according to the size of their σ-hole. Instead, mutation of the gatekeeper residue into leucine, alanine, or threonine reveals that the heavier halides can significantly influence selectivity in the human kinome. Thus, we demonstrate that, although the choice of halogen may not always increase affinity, it can still be relevant for inducing selectivity. Determining the crystal structure of the iodine derivative in complex with JNK3 (4X21) reveals an unusual bivalent halogen/chalcogen bond donated by the ligand and the back-pocket residue MET115. Incipient repulsion from the too short halogen bond increases the flexibility of Cε of MET146, whereas the rest of the residue fails to adapt being fixed by the chalcogen bond. This effect can be useful to induce selectivity, as the necessary combination of methionine residues only occurs in 9.3% of human kinases, while methionine is the predominant gatekeeper (39%).

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1452-77-3, is researched, Molecular C6H6N2O, about Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization, the main research direction is Fragment screening; Ligand-protein interaction; Molecular docking; RNA-binding proteins; SPR; STD-NMR.Name: Picolinamide.

Hu proteins are members of the RNA-binding protein (RBP) family and play a pivotal role in the regulation of post-transcriptional processes. Through interaction with selected mRNAs, RBPs regulate their function and stability; as a consequence, RBP dysregulation can cause abnormal translation of key proteins involved in several pathologies. In the past few years, this observation has sparked interest to develop new treatments against these pathologies by using small mols. able to modulate RBP activity. Among the four Hu proteins, we have directed our efforts towards the isoform HuR, which is mainly involved in cancer, inflammation and retinopathy. Aimed at developing compounds able to modulate the stability of HuR-mRNA complexes, in the present work, we applied a biophys. fragment screening by assessing a library of halogen-enriched heterocyclic fragments (HEFLibs) via Surface Plasmon Resonance (SPR) and Saturation Transfer Difference (STD) NMR to select promising fragments able to interact with HuR. One selected fragment and a few com. available congeners were exploited to design and synthesize focused analogs of compound N-(3-chlorobenzyl)-N-(3,5-dihydroxyphenethyl)-4-hydroxybenzamide (1), our previously reported hit. STD NMR spectroscopy, mol. modeling, and SPR offered further insight into the HuR-small mol. interaction and showed that fragment-based approaches represent a promising and yet underexplored strategy to tackle such unusual targets. Lastly, fluorescence polarization (FP) studies revealed the capability of the new compounds to interfere with the formation of the HuR-mRNA complex. This is, to our knowledge, the first fragment-based campaign performed on the Hu protein class, and one of the few examples in the larger RBP field and constitutes an important step in the quest for the rational modulation of RBPs and related RNA functions by small mols.

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Tetrahydroisoquinoline – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of nitrogen containing biocompatible non-ionic surfactants and investigation for their self-assembly based nano-scale vesicles, published in 2019-01-31, which mentions a compound: 693-67-4, Name is 1-Bromoundecane, Molecular C11H23Br, Recommanded Product: 693-67-4.

Nonionic surfactants are increasingly interesting because of the solubility and release of drugs. Here, a synthesis of four nonionic nitrogen-containing surfactants is reported. In the synthesis, sulfonamide was reacted with alkyl halides of different lipophilicity. The synthesized nonionic surfactants were characterized by 1H NMR and mass spectroscopy. Their critical micelle concentration (CMC) was determined with a UV spectrophotometer. The self-assembly of surfactants to form drug-loaded, niosomal vesicles with Simvastatin as model drug was investigated. The resulting niosoaml vesicles were characterized by at. force microscope (AFM), zeta-sizer, and UV spectrophotometer for shape, size, polydispersity index, zeta potential, and drug inclusion efficiency. Their biocompatibility has been determined by blood hemolysis and cell toxicity tests. The synthesized surfactants showed low CMC values and were able to form nano-sized round niosomal vesicles with a homogeneous population and surface negativity. Depending on the lipophilicity, they absorbed an increased amount of drug. The biocompatibility studies show that the surfactants are hemocompatible and non-toxic. The results of the study confirm that the synthesized nonionic surfactants are suitable for the solubilization and release of hydrophobic drugs as efficient novel biocompatible carriers.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Application of 1452-77-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Highly Efficient Synthesis of Alkyl N-Arylcarbamates from CO2, Anilines, and Branched Alcohols with a Catalyst System of CeO2 and 2-Cyanopyridine. Author is Gu, Yu; Miura, Ayaka; Tamura, Masazumi; Nakagawa, Yoshinao; Tomishige, Keiichi.

Highly efficient synthesis of alkyl N-arylcarbamates from CO2, anilines, and alcs. using the CeO2 and 2-cyanopyridine catalyst system was substantiated by selecting branched alcs., such as 2-propanol and cyclohexanol, with minimized formation of byproducts, such as dialkyl carbonates and picolinamide. The catalyst system is operable even at low CO2 pressure (≤1 MPa), and the target carbamates were obtained with high arylamine-based yields (up to 94%). Alkyl N-phenylcarbamates were obtained from CO2, anilines, and alcs. with high yield and minimized formation of byproducts by using branched alcs.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ali, Imdad; Manzoor, Hiba; Imran, Muhamad; Shafiulah; Shah, Muhammad Raza researched the compound: 1-Bromoundecane( cas:693-67-4 ).Formula: C11H23Br.They published the article 《Synthesis of nitrogen containing biocompatible non-ionic surfactants and investigation for their self-assembly based nano-scale vesicles》 about this compound( cas:693-67-4 ) in Tenside, Surfactants, Detergents. Keywords: nitrogen simvastatin nonionic surfactant self assembly biocompatibility. We’ll tell you more about this compound (cas:693-67-4).

Nonionic surfactants are increasingly interesting because of the solubility and release of drugs. Here, a synthesis of four nonionic nitrogen-containing surfactants is reported. In the synthesis, sulfonamide was reacted with alkyl halides of different lipophilicity. The synthesized nonionic surfactants were characterized by 1H NMR and mass spectroscopy. Their critical micelle concentration (CMC) was determined with a UV spectrophotometer. The self-assembly of surfactants to form drug-loaded, niosomal vesicles with Simvastatin as model drug was investigated. The resulting niosoaml vesicles were characterized by at. force microscope (AFM), zeta-sizer, and UV spectrophotometer for shape, size, polydispersity index, zeta potential, and drug inclusion efficiency. Their biocompatibility has been determined by blood hemolysis and cell toxicity tests. The synthesized surfactants showed low CMC values and were able to form nano-sized round niosomal vesicles with a homogeneous population and surface negativity. Depending on the lipophilicity, they absorbed an increased amount of drug. The biocompatibility studies show that the surfactants are hemocompatible and non-toxic. The results of the study confirm that the synthesized nonionic surfactants are suitable for the solubilization and release of hydrophobic drugs as efficient novel biocompatible carriers.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

COA of Formula: C6H6N2O. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Synthesis and characterization of N-Chloropicolinamide: a new, mild, stable, effective and efficient oxidant for organic substrates. Author is Subalakshmi, M.; Priya, V..

The new oxidant N-Chloropicolinamide (NCP) is synthesized by the chlorination of picolinamide using trichloroisocyanuric acid. The phys. constant, formal redox potential, element anal. and spectra characterization (IR, UV, 1H-NMR, C13-NMR and mass spectrum) confirms the presence of nitrogen-halogen bond. It is prepared by a simple method giving a high yield in a short period of time. It is found to be a mild and stable oxidant and formal redox potential of N-chloropicolinamide shows that it can be used as an effective source of pos. halogen.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Category: tetrahydroisoquinoline. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Synthesis and characterization of N-Chloropicolinamide: a new, mild, stable, effective and efficient oxidant for organic substrates. Author is Subalakshmi, M.; Priya, V..

The new oxidant N-Chloropicolinamide (NCP) is synthesized by the chlorination of picolinamide using trichloroisocyanuric acid. The phys. constant, formal redox potential, element anal. and spectra characterization (IR, UV, 1H-NMR, C13-NMR and mass spectrum) confirms the presence of nitrogen-halogen bond. It is prepared by a simple method giving a high yield in a short period of time. It is found to be a mild and stable oxidant and formal redox potential of N-chloropicolinamide shows that it can be used as an effective source of pos. halogen.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Quality Control of cis-Dichlorobis(pyridine)platinum(II). The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Infrared spectroscopic study of dicyanato complexes of platinum. Author is Kharitonov, Yu. Ya.; Evstaf’eva, O. N.; Baranovskii, I. B.; Mazo, G. Ya..

trans-[Pt(NH3)2(CN)2] (I), trans-[Pt(ND3)2(CN)2], trans-Pt(NH3)2(CN)2.AgNO3, trans-[Pt(NH3)2(CN)2X2] (II) where X = Cl, Br, I, or OH, trans-[Pt(ND3)2(CN)2X2] where X = Br or I, cis-[PtA(CN)2] where A = (NH3)2, (pyridine)2, ethylenediamine, or (thiourea)2, cis-[Pten(CN)2X2] where X is Br or OH were studied by ir spectroscopy. Maximum of these compounds are tabulated. On oxidation of Pt, the νpt-CN did not change while νC-N increased ∼40-70 cm.-1 All trans complexes had a singlet and all cis had a doublet νCN. The split for cis complexes was larger for Pt(II) than for Pt(IV). The force constant of the C-N bond changed insignificantly, especially in Pt(II) complexes, on transition from ionic to covalent cyanides. Apparently the σ-bond contribution is larger in Pt(IV) than in Pt(II) complexes. When I was oxidized to II (X = Br) and, this subsequently became reduced, the product obtained was identical with the starting material. The complexes did not rearrange on oxidation and the nature of the X in II did not affect the Pt-N bonds. The νPt-N of trans isomers were at ∼525-31 cm.-1 for Pt(II) or Pt(IV). For the complexes studied, the overall (σ + π) bond strength of Pt-N was approx. the same in Pt(II) and Pt(IV) complexes.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

HPLC of Formula: 1452-77-3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Metal-free nitrogen -doped carbon nanosheets: a catalyst for the direct synthesis of imines under mild conditions. Author is Wang, Kaizhi; Jiang, Pengbo; Yang, Ming; Ma, Ping; Qin, Jiaheng; Huang, Xiaokang; Ma, Lei; Li, Rong.

Herein, a highly stable, porous, multifunctional and metal-free catalyst was developed, which exhibited significant catalytic performance in the oxidation of amines and transfer hydrogenation of nitriles under mild conditions; this could be attributed to the presence of numerous active sites and their outstanding BET surface area. The obtained results showed that most of the yields of imines exceeded 90%, and the cycling performance of the catalyst could be at least seven runs without any decay in the reaction activity, which could be comparable to those of metal catalysts. Subsequently, a kinetic study has demonstrated that the apparent activation energy for the direct synthesis of imines from amines is 67.39 kJ mol-1, which has been performed to testify that the catalytic performances are rational. Via catalyst characterizations and exptl. data, graphitic-N has been proven to be the active site of the catalyst. Hence, this study is beneficial to comprehend the mechanism of action of a metal-free N-doped carbon catalyst in the formation of imines.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem