Category: tetrahydroisoquinoline

Product Details of 1452-77-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Aerobic Activation of C-H Bond in Amines Over a Nanorod Manganese Oxide Catalyst. Author is Wang, Hai; Wang, Liang; Wang, Sai; Dong, Xue; Zhang, Jian; Xiao, Feng-Shou.

The development of heterogeneous catalysts for the synthesis of pharmaceutically relevant compounds is always important for chem. research. Here, we report a selective aerobic oxidation of aromatic and aliphatic amines to corresponding amides over a nanorod manganese oxide (NR-MnOx) catalyst. The kinetic studies reveal that the NR-MnOx catalyzed amine-to-amide reaction proceeds the oxidative dehydrogenation of the amines into nitriles, followed by hydrolysis of nitrile into amides. The NR-MnOx exhibits fast kinetics and high selectivities in these steps, as well as hinders the byproduct formation. More importantly, the NR-MnOx catalyst is stable and reusable in the continuous recycle tests with water as a sole byproduct, exhibiting superior sustainability and significant advancement to outperform the traditional amide production route in acidic or basic media with toxic byproducts.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Computed Properties of C11H23Br. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about 4-Carboalkoxylated Polyvalerolactones from Malic Acid: Tough and Degradable Polyesters. Author is Fahnhorst, Grant W.; De Hoe, Guilhem X.; Hillmyer, Marc A.; Hoye, Thomas R..

Eight 4-carboalkoxyvalerolactones (CRVLs), varying in the composition of their alkyl (R) side chains, were synthesized from malic acid and subjected to ring-opening transesterification polymerization (ROTEP) using di-Ph phosphate [DPP, (PhO)2PO2H] as a catalyst. Each CRVL produced a semicrystalline poly(4-carboalkoxyvalerolactone) (PCRVL), and the nature of the R group impacted the thermal transitions of these polyesters. Bulk polymerizations at 70°C allowed for preparation of high molar mass samples that contained small amounts of branching, as evidenced by 1H NMR spectroscopy, MALDI spectrometry, size-exclusion chromatog., and eliminative degradation Tensile testing of these lightly branched, high molar mass samples revealed that these polyesters are tough (tensile toughness values up to 88 ± 33 MJ•m-3) and have Young’s moduli (E) up to 186 ± 13 MPa. The acid- and base-catalyzed hydrolytic degradation of the PCRVLs was quant. monitored using total organic carbon anal., and effect of the alkyl chain length on PCRVL hydrolysis rate was determined Finally, the Me ester variant of these malic acid-derived thermoplastics is known to be chem. recyclable.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Name: cis-Dichlorobis(pyridine)platinum(II). The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Trifluoromethanesulfonato-O complexes of platinum(II) and palladium(II). Author is Diver, Catherine; Lawrance, Geoffrey A..

Reaction of chloroplatinum(II) and chloropalladium(II) complexes containing amine, pyridine, or phosphine ligands at or above room temperature with anhydrous CF3SO3H gave F3CSO3–O complexes, characterized spectroscopically. The complexes cis-[Pt(NH3)2(OSO2CF3)2], trans-[Pt(NH3)2Cl(OSO2CF3)], Pt(en)Cl(OSO2CF3)], [Pt(dppe)(OSO2CF3)2], [Pt(py)2Cl(OSO2CF3)], [Pt(terpy)(OSO2CF3)][CF3SO3], (terpy = 2,2′:6′,2′-terpyridine), trans-[Pd(NH3)2Cl(OSO2CF3)], [Pd(en)(OSO2CF3)2], [Pd(bpy)(OSO2CF3)2] (bpy = 2,2′-bipyridine), and [Pd(PPh3)2(OSO2CF3)2] were isolated. Aquation reactions of selected complexes showed that F3CSO3- hydrolysis is rapid for complexes of both PtII and PdII. Pt(O3SCF3)2 complexes exhibit 2 consecutive rate processes, with k1/k2 ca. 5, consistent with sequential hydrolysis of both anions. Coordinated CF3SO3- in these complexes may be substituted even by neutral coordinating O-donor solvents.

In addition to the literature in the link below, there is a lot of literature about this compound(cis-Dichlorobis(pyridine)platinum(II))Name: cis-Dichlorobis(pyridine)platinum(II), illustrating the importance and wide applicability of this compound(15227-42-6).

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Reference of 1-Bromoundecane. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Catalytic Asymmetric Fluorination of Copper Carbene Complexes: Preparative Advances and a Mechanistic Rationale. Author is Buchsteiner, Michael; Martinez-Rodriguez, Luis; Jerabek, Paul; Pozo, Iago; Patzer, Michael; Noethling, Nils; Lehmann, Christian W.; Fuerstner, Alois.

The Cu-catalyzed reaction of substituted α-diazoesters with fluoride gives α-fluoroesters with ee values of up to 95%, provided that chiral indane-derived bis(oxazoline) ligands were used that carry bulky benzyl substituents at the bridge and moderately bulky iso-Pr groups on their core. The apparently homogeneous solution of CsF in C6F6/hexafluoroisopropanol (HFIP) is the best reaction medium, but CsF in the biphasic mixture CH2Cl2/HFIP also provides good results. DFT studies suggest that fluoride initially attacks the Cu- rather than the C-atom of the transient donor/acceptor carbene intermediate. This unusual step is followed by 1,2-fluoride shift; for this migratory insertion to occur, the carbene must rotate about the Cu-C bond to ensure orbital overlap. The directionality of this rotatory movement within the C2-sym. binding site determines the sense of induction. This model is in excellent accord with the absolute configuration of the resulting product as determined by x-ray diffraction using single crystals of this a priori wax-like material grown by capillary crystallization

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Bromoundecane(SMILESS: CCCCCCCCCCCBr,cas:693-67-4) is researched.Recommanded Product: Picolinamide. The article 《A simple and efficient approach for the synthesis of a novel class aliphatic 1,3,4-thiadiazol-2(3H)-one derivatives via intramolecular nucleophilic substitution reaction》 in relation to this compound, is published in Synthetic Communications. Let’s take a look at the latest research on this compound (cas:693-67-4).

In this study, a new series of substituted 1,3,4-thiadiazol-2(3H)-one derivatives I [R = Et, CH2CH=CH2, cyclohexylmethyl, etc.] was synthesized in yields ranging from 42 to 70% via reaction of alkyl bromides with 1-(4-chlorophenyl)-2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)ethanol with an interesting mechanism that involved internal nucleophilic substitution followed by an SN2-type nucleophilic substitution. First, 1-(4-chlorophenyl)-2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)ethanone was synthesized from the reaction of 5-methyl-1,3,4-thiadiazole-2-thiol with 2-bromo-1-(4-chlorophenyl)ethanone which underwent reduction to afford 1-(4-chlorophenyl)-2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)ethanol. The advantages of this protocol were synthesis of target compounds under mild conditions using simple synthetic methods and obtaining them without phosgene.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Ligand effects in platinum binding to DNA. A comparison of DNA binding properties for cis- and trans-[PtCl2(amine)2] (amine = NH3, pyridine).Reference of cis-Dichlorobis(pyridine)platinum(II).

The DNA binding properties of cis- and trans-[PtCl2(pyridine)2] have been examined and compared with their NH3 analogs, cis- and trans-DDP. The presence of a planar ligand reduces the rates of DNA binding but does not greatly affect the overall conformation of CT DNA, as measured by CD spectroscopy. The sequence specificity of trans-[PtCl2(py)2] includes alternating purine-pyrimidine sequences. The sequence specificity is further different between the two pyridine isomers, and the steric effects of two cis-pyridine groups are demonstrated by the appearance of relatively few binding sites in the 49-bp duplex. The effects of the pyridine ligand are further manifested by a greatly enhanced DNA-DNA interstrand crosslinking efficiency for the trans isomer, with a cross-link per adduct frequency of between 0.14 and 0.23, depending on the rb of the sample. The unwinding of closed circular pUC19 DNA by trans-[PtCl2(pyridine)2] is also more efficient than that by either DDP isomer. In contrast, little unwinding is induced by cis-[PtCl2(pyridine)2]. These results invert the standard cis/trans structure-activity relationships observed previously for [PtCl2(NH3)2]. The results are discussed with respect to the previously demonstrated effect of activation of the trans-platinum geometry using sterically hindered ligands.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Conformational properties of purine and pyrimidine complexes of cis-platinum. Implications for platinum(II)-DNA crosslinking modes, the main research direction is platinum complex conformation DNA binding; structure activity platinum complex; neoplasm inhibitor platinum complex; stereochem DNA platinum complex.Safety of cis-Dichlorobis(pyridine)platinum(II).

The stereochem. properties of a variety of cis complexes of Pt(II) containing purine or pyrimidine ligands are examined The critical intramol. conformational parameters [the interbase dihedral angle and the base/coordination plane dihedral angles] are systematically studied and trends sought. Where intramol. interactions are determinative of the adopted mol. conformation, the nature of the steric demands imposed by increasing numbers of exocyclic functional groups contiguous to the Pt binding site are clearly of major importance for the antitumor activity.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Diver, Catherine; Lawrance, Geoffrey A. published the article 《Trifluoromethanesulfonato-O complexes of platinum(II) and palladium(II)》. Keywords: trifluoromethanesulfonato palladium platinum complex; hydrolysis kinetics trifluoromethanesulfonato platinum.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Formula: C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

Reaction of chloroplatinum(II) and chloropalladium(II) complexes containing amine, pyridine, or phosphine ligands at or above room temperature with anhydrous CF3SO3H gave F3CSO3–O complexes, characterized spectroscopically. The complexes cis-[Pt(NH3)2(OSO2CF3)2], trans-[Pt(NH3)2Cl(OSO2CF3)], Pt(en)Cl(OSO2CF3)], [Pt(dppe)(OSO2CF3)2], [Pt(py)2Cl(OSO2CF3)], [Pt(terpy)(OSO2CF3)][CF3SO3], (terpy = 2,2′:6′,2′-terpyridine), trans-[Pd(NH3)2Cl(OSO2CF3)], [Pd(en)(OSO2CF3)2], [Pd(bpy)(OSO2CF3)2] (bpy = 2,2′-bipyridine), and [Pd(PPh3)2(OSO2CF3)2] were isolated. Aquation reactions of selected complexes showed that F3CSO3- hydrolysis is rapid for complexes of both PtII and PdII. Pt(O3SCF3)2 complexes exhibit 2 consecutive rate processes, with k1/k2 ca. 5, consistent with sequential hydrolysis of both anions. Coordinated CF3SO3- in these complexes may be substituted even by neutral coordinating O-donor solvents.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Picolinamide( cas:1452-77-3 ) is researched.Category: tetrahydroisoquinoline.Chen, Chao-Cheng; Chen, Yang-Yi; Lo, Yi-Hsuan; Lin, Ming-Hsien; Chang, Chih-Hsien; Chen, Chuan-Lin; Wang, Hsin-Ell; Wu, Chun-Yi published the article 《Evaluation of radioiodinated fluoronicotinamide/fluoropicolinamide-benzamide derivatives as theranostic agents for melanoma》 about this compound( cas:1452-77-3 ) in International Journal of Molecular Sciences. Keywords: melanoma theranostic agent radioiodinated fluoronicotinamide fluoropicolinamide benzamide; 131I-iodofluoronicotiamide benzamide (131I-IFNABZA); 131I-iodofluoropicolinamide benzamide (131I-IFPABZA); melanoma; theranostic agent. Let’s learn more about this compound (cas:1452-77-3).

Malignant melanoma is the most harmful type of skin cancer and its incidence has increased in this past decade. Early diagnosis and treatment are urgently desired. In this study, we conjugated picolinamide/nicotinamide with the pharmacophore of 131I-MIP-1145 to develop 131I-iodofluoropicolinamide benzamide (131I-IFPABZA) and 131I-iodofluoronicotiamide benzamide (131I-IFNABZA) with acceptable radiochem. yield (40 ± 5%) and high radiochem. purity (>98%). We also presented their biol. characteristics in melanoma-bearing mouse models. 131I-IFPABZA (Log P = 2.01) was more lipophilic than 131I-IFNABZA (Log P = 1.49). B16F10-bearing mice injected with 131I-IFNABZA exhibited higher tumor-to-muscle ratio (T/M) than those administered with 131I-IFPABZA in planar γ-imaging and biodistribution studies. However, the imaging of 131I-IFNABZA- and 131I-IFPABZA-injected mice only showed marginal tumor uptake in A375 amelanotic melanoma-bearing mice throughout the experiment period, indicating the high binding affinity of these two radiotracers to melanin. Comparing the radiation-absorbed dose of 131I-IFNABZA with the melanin-targeted agents reported in the literature, 131I-IFNABZA exerts lower doses to normal tissues on the basis of similar tumor dose. Based on the in vitro and in vivo studies, we clearly demonstrated the potential of using 131I-IFNABZA as a theranostic agent against melanoma.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Picolinamide(SMILESS: O=C(N)C1=NC=CC=C1,cas:1452-77-3) is researched.Category: tetrahydroisoquinoline. The article 《Ethene-1,1,2,2-tetracarbonitrile and Methanol in the Methylating Reaction of Tertiary Amines to the Quaternary Ammonium Compounds of 1,1-Dicyano-2-methoxy-2-oxoethane-1-ide》 in relation to this compound, is published in Synlett. Let’s take a look at the latest research on this compound (cas:1452-77-3).

We discovered a new method to methylate tertiary amines such as urotropine, triethylamine, pyridine, 2-methylpyridine, 4-acetylpyridine, and isonicotinamide, to quaternary ammonium compounds, with 1,1-dicyano-2-methoxy-2-oxoethane-1-ide being the counterion. Methyl-1,3,5,7-tetraazaadamantan-1-ium 1,1-dicyano-2-methoxy-2-oxoethane-1-ide, N,N-diethyl-N-methylethanaminium 1,1-dicyano-2-methoxy-2-oxoethane-1-ide, and substituted-methylpyridinium 1,1-dicyano-2-methoxy-2-oxoethane-1-ides were synthesized. Quaternary ammonium compounds of 1,1-dicyano-2-methoxy-2-oxothane-1-ide were synthesized within a single stage by stirring methanol solutions of tertiary amines with ethene-1,1,2,2-tetracarbonitrile (ETCN) at room temperature In the reaction of ETCN with tertiary amines in methanol, processes occur that form the 1,1-dicyano-2-methoxy-2-oxoethane-1-ide fragment with simultaneous N-methylation. Crystal structures based on X-ray diffraction anal. of the obtained compounds were studied.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem