Heterocyclic Building Blocks-Tetrahydroisoquinoline

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II).Farrell, Nicholas; Ha, Tam T. B.; Souchard, Jean Pierre; Wimmer, Franz L.; Cros, Suzy; Johnson, Neil P. published the article 《Cytostatic trans-platinum(II) complexes》 about this compound( cas:15227-42-6 ) in Journal of Medicinal Chemistry. Keywords: platinum pyridine complex antitumor isomerism. Let’s learn more about this compound (cas:15227-42-6).

The unusual cytostatic properties of trans-Pt(II) complexes of pyridine, trans-[PtCl2L2] (L = pyridine, 4-methylpyridine), are reported. The complexes demonstrate increased cytostatic activity to L1210 leukemia cells over the cis-pyridine analogs and had activity equivalent to that of cisplatin. The results have implications for the design of structurally novel Pt antitumor agents.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Half-Sandwich Iridium Complexes for the One-Pot Synthesis of Amides: Preparation, Structure, and Diverse Catalytic Activity, the main research direction is iridium half sandwich Schiff base complex preparation hydration catalyst; nitrile hydration oxime rearrangement preparation aromatic amide iridium catalyst; crystal structure iridium half sandwich Schiff base complex; mol structure iridium half sandwich Schiff base complex.Category: tetrahydroisoquinoline.

Several types of air-stable N,O-coordinate half-sandwich iridium complexes containing Schiff base ligands with the general formula [Cp*IrClL] were synthesized in good yields. These stable iridium complexes displayed a good catalytic efficiency in amide synthesis. A variety of amides with different substituents were obtained in a one-pot procedure with excellent yields and high selectivities through the amidation of aldehydes with NH2OH·HCl and nitrile hydration under the catalysis of complexes 1-4. The excellent and diverse catalytic activity, mild conditions, broad substance scope, and environmentally friendly solvent make this system potentially applicable in industrial production Half-sandwich iridium complexes 1-4 were characterized by NMR, elemental anal., and IR techniques. Mol. structures of complexes 2 and 3 were confirmed by single-crystal X-ray anal. Half-sandwich iridium complexes were synthesized, which exhibited a high catalytic activity for amide synthesis in a one-pot procedure with excellent yields and high selectivity through aldehyde amidation or nitrile hydration. The broad substrate scope, mild reaction conditions, and high yields of the products made this catalytic system attractive in the industrial process.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Separation and Purification Technology called Dipicolinamide functionalized titania for highly efficient sorption of tetra and hexavalent actinide, Author is Pahan, Sumit; Sengupta, Arijit; Musharaf Ali, Sk.; Debnath, A. K.; Banerjee, D.; Vincent, T.; Sugilal, G.; Kaushik, C. P., which mentions a compound: 1452-77-3, SMILESS is O=C(N)C1=NC=CC=C1, Molecular C6H6N2O, Synthetic Route of C6H6N2O.

Dipicolinamide functionalized titania particles have been synthesized for efficient decontamination of uranyl and thorium ions from aqueous acidic waste solution Langmuir isotherm was found to be predominating with maximum sorption capacity of 125 mg/g for Th and 111 mg/g for U, resp. The sorption was found to follow pseudo 2nd order kinetics predominately, with rate constant 8.6E-04 mg g-1 min-1 for Th and 6.1E-04 mg g-1 min-1 for U, resp. Up to 200 kGy of gamma irradiation, not much deterioration in extraction performance of sorbent material was observed Three contacts of 0.1 M aqueous solutions of oxalic acid and sodium carbonate were found to be effective in quant. elution of Th4+ and UO2+2 from the loaded sorbent, resp. The sorption of U and Th on dipicolinamide functionalized titania was evidenced by SEM images, elemental mapping and the EDX. Theor. investigation revealed that, the solution phase free energy of sorption (ΔGsol) was higher for Th4+ (-114.1 kcal mol-1) compared to UO2+2 (-80.41 kcal mol-1).

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Tetrahydroisoquinoline – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Redistribution of ligands in [Rh(CO)A(PPh3)2][Pt(py)Cl3], published in 1990, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Synthetic Route of C10H10Cl2N2Pt.

[Rh(CO)A(PPh3)2][Pt(py)Cl3].DMF (I; A = py, 4-picoline (pic), 2,2′-bipyridine (bpy), 1,10-phenanthroline (phen)) were prepared by the reaction of [Rh(CO)A(PPh3)2]NO3 with K[Pt(py)Cl3] in DMF. For I (A = py, pic) at room temperature in DMF, Me2CO, CHCl3 or C6H6 after 15-30 min., redistribution of ligands occurred with the formation of Rh(CO)(PPh3)2Cl and cis-Pt(py)ACl2. I (A = bpy, phen) are stable in solution

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Safety of cis-Dichlorobis(pyridine)platinum(II). So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Experimental and quantum-chemical studies of 15N NMR coordination shifts in palladium and platinum chloride complexes with pyridine, 2,2′-bipyridine and 1,10-phenanthroline.

Pd and Pt chloride complexes with pyridine (py),2,2′-bipyridine (bpy) and 1,10-phenanthroline (phen), trans-/cis-[M(py)2Cl2], [M(py)4]Cl2, trans-/cis-[M(py)2Cl4], [M(bpy)Cl2], [M(bpy)Cl4], [M(phen)Cl2], [M(phen)Cl4], where M = Pd, Pt, was studied by 1H, 195Pt, and 15N NMR. The 90-140 ppm low-frequency 15N coordination shifts are discussed in terms of such structural features of the complexes as the type of platinide metal, oxidation state, coordination sphere geometry and the type of ligand. The results of quantum-chem. NMR calculations were compared with the exptl. 15N coordination shifts, well reproducing their magnitude and correlation with the mol. structure.

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Computed Properties of C6H6N2O. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Bis-heteroleptic ruthenium(II) complex with 2-picolinamide: Synthesis, crystal structures, and spectroscopic study for anion recognition using the amide group. Author is Toyama, Mari; Fujii, Yudai; Endo, Mika.

Cis-[Ru(bpy)2(OH2)2](OTf)2 (1·(OTf)2; OTf- = CF3SO3-) was reacted with 2-picolinamide (H2pia) in EtOH to form bis-heteroleptic complex [Ru(bpy)2(H2pia)]X2 (2·X2; X- = OTf- or Cl-). Crystal structures of 2·X2 revealed that H2pia was coordinated to Ru(II) through N of pyridyl group and O of amide group to form the N,O-coordination, and acted as a neutral ligand. Bond distances around the amide group and 1H NMR study for 22+ suggested that π-electron on the carbonyl group was delocalized to the whole amide group. Adding F- to the acetonitrile solution of 2·(OTf)2 changed the red solution to dark-red due to the transportation of π-electron on the amide group by the bound F- to the amide H. Absorption and 1H NMR spectroscopies revealed that the NH2 of 22+ undergoes selective two-step adduct reaction with F-: the H close to pyridyl group of H2pia first formed a 1:1 adduct (mono-F-adduct-22+), followed by the other H forming the 1:2 adduct (di-F-adduct-22+). Adding excess Li(OTf) to these F-adduct-22+ solutions changed the dark-red solution back to red, suggesting that the adducted F- was removed by Li+ to form 22+ and LiF.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Interaction of pyridineplatinum(II) complexes with alkyl sulfoxides, published in 2008-08-31, which mentions a compound: 15227-42-6, mainly applied to platinum pyridine complex reaction sulfoxide; isomerization pyridine sulfoxide complex, Related Products of 15227-42-6.

The reaction of cis- and trans-[Pt(py)2Cl2] and [Pt(py)4]Cl2 with DMSO and Et2SO was studied by NMR. The products of the reaction are pyridine sulfoxide complexes and bis(sulfoxide) complexes. With heating cis/trans isomerization occurred, determining the configuration of the final products.

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Tetrahydroisoquinoline – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Al-Zamil, Nabila S.; Evans, E. H. M.; Gillard, R. D.; James, David W.; Jenkins, Tudor E.; Lancashire, Robert J.; Williams, P. A. researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Product Details of 15227-42-6.They published the article 《Adducts of coordination compounds – 12. New hydrogen dinitrates and their structures》 about this compound( cas:15227-42-6 ) in Polyhedron. Keywords: hydrogen dinitrate preparation structure; ruthenium cationic complex hydrogen dinitrate; phenanthridinium hydrogen dinitrate; phenanthrolinium hydrogen dinitrate; iridium cation complex hydrogen dinitrate; crystal structure hydrogen dinitrate; structure ruthenium complex hydrogen dinitrate. We’ll tell you more about this compound (cas:15227-42-6).

The new compounds trans-[Ru(py)4Cl2][H(ONO2)2] and [C13H9NH][H(ONO2)2] were characterized (C13H9N = phenanthridine) and these, with the known compounds trans-[Ir(py)4Cl2][H(ONO2)2], C13H9N.2HNO3.2H2O and [phenH][H(ONO2)2] (phen = 1,10-phenanthroline) shown to involve the H dinitrate ion. The crystal and mol. structure of the Ru complex was determined The orthorhombic unit cell, space group Pbcn has a 7.54, b 21.83, c 14.86 (±0.01) Å, Z = 4. The compound is isomorphous with the analogous Rh(III) complex, but has addnl. disorder involving the nitrate groups owing to loss of HNO3 with time to yield an isostructural mononitrate compound trans-[Ru(py)4Cl2][H(ONO2)2] and trans-[Pt(py)4Cl2](NO3)2 were obtained under conditions previously described as giving rise to nitration of the pyridine ring. In fact, no evidence for the formation of 3-nitropyridine was found during these studies.

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Tetrahydroisoquinoline – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Bis(pentafluorophenyl) complexes of palladium(II) and of platinum(II), published in 1974, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Synthetic Route of C10H10Cl2N2Pt.

The preparation of 8 bis(pentafluorophenyl) complexes of Pd(II) and of Pt(II) with monodentate and bidentate N-donor ligands is described together with a preparation of a Pd(II) complex of 1,2-bis(diphenylphosphino)ethane. Assignments of cis or trans configuration are discussed which depend upon the splitting or disappearance of certain bands in ir.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 693-67-4, is researched, Molecular C11H23Br, about Effect of n-alkyl substitution on Cu(II)-selective chemosensing of rhodamine B derivatives, the main research direction is alkyl substitution copper fluorescent sensor rhodamine B derivative.Recommanded Product: 693-67-4.

Rhodamine B hydrazide-based mol. probes (1-10) were synthesized by derivatization with n-alkyl chains of different lengths at the hydrazide amino end. These probes exhibited selective absorption (A∼557) and fluorescence (I∼580) ‘off-on’ signal transduction along with a colorless → magenta color transition in the presence of Cu(II) ions among all the competitive metal ions investigated. The effective coordination of these probes to Cu(II) ions under the investigated environment forming [Cu·L]2+ (L = 1-5) and [Cu·L2]2+ (L = 6-10) complexes led to their spiro-ring opening, which in turn was expressed through signatory spectral peaks of ring-opened rhodamine. All these probes exhibited Cu(II) selectivity in signalling despite structural modifications to the core receptor unit through variation of the nature of the alkyl substituents. However, the sensitivity of the signalling and kinetics of the spiro-ring opening varied and could be correlated with the number of carbon atoms present in the n-alkyl substituents. Structural elucidation with X-ray diffraction and X-ray photoemission spectroscopic analyses provided further insight into the structure-function correlation in their Cu(II) complexes. These probes with Cu(II) coordination showed selectivity in signalling, high complexation affinity (log Ka = 4.8-8.8), high sensitivity (LOD = 4.1-80 nM), fast response time (rate = 0.0017-0.0159 s-1) and reversibility with counter anions, which ascertained their potential utility as chemosensors for Cu(II) ion detection.

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Tetrahydroisoquinoline – Wikipedia,
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